Omentin-1 Changes following Biliopancreatic Diversion and Relationship with Cardiovascular Risk Factors

Abstract

Introduction: Omentin-1 might play a role in the pathogenesis of insulin resistance and obesity. The aim of the present study was to evaluate the influence of weight loss after biliopancreatic diversion on serum omentin-1 concentrations. Material and Methods A Caucasian population of 24 morbid obese patients was analyzed before and after 12 months of a biliopancreatic diversion surgery. Biochemical and anthropometric evaluation were realized at basal visit and at 12 months. Body weight, fat mass, waist circumferences, blood pressure, fasting blood glucose, fasting insulin, insulin resistance (HOMA-IR), lipid concentrations and omentin-1 were measured. Results: After bariatric surgery and in both gender groups (males vs. females); BMI, weight, fat mass, waist circumference, blood pressure, glucose , total cholesterol, LDL cholesterol, triglycerides, HOMA-IR and fasting insulin decreased in a statistical manner from basal values. Omentin-1 levels increased after bariatric surgery and in both gender the improvement was similar (males vs. females); (delta: –87.1 ± 19.0 ng/dL; p = 0.02 vs. –93.8 ± 28.1 ng/dL; p = 0.03). In the multiple regression analysis adjusted by age and sex; BMI kg/m² (Beta –0.32: 95% CI –3.98 to –0.12) and insulin UI/L (Beta –0.41: 95% CI –8.38 to –0.16) remained in the model with basal omentin-1 levels as dependent variable. The regression model with post-surgery omentin-1 levels as dependent variable showed as independent variables BMI kg/m² (Beta –0.13: 95% CI –7.69 to –0.09) and insulin UI/L (Beta –0.24: 95% CI –5.69 to –0.08), too. Conclusion: This study showed a significant increase in omentin-1 levels after weight loss secondary biliopancreatic diversion surgery. A weak negative correlation with BMI and basal insulin levels was detected.

Changes of body composition and circulating neopterin, omentin‐1, and chemerin in response to thylakoid‐rich spinach extract with a hypocaloric diet in obese women with polycystic ovary syndrome: A randomized controlled trial

“…Our finding was in agreement with the studies of de Luis et al in which weight-loss and body fat-loss treatments by hypocaloric diet and bariatric surgery (de Luis, García Calvo, et al, 2018) could significantly increase the blood levels of omentin-1 in obese subjects. As known so far, this is the first report concerning the combined effects of thylakoid-rich spinach extract supplementation and caloric restriction on circulating levels of omentin-1 and chemerin; more human studies would clarify the subject.…”

“…To date, few studies have evaluated the effects of hypocaloric diet or nutritional interventions on blood levels of omentin‐1 and chemerin (de Luis et al, 2018; de Luis, Izaola, Primo, & Aller, 2018; Farhangi, Alipour, Jafarvand, & Khoshbaten, 2014; Lesná et al, 2015). Our finding was in agreement with the studies of de Luis et al in which weight‐loss and body fat‐loss treatments by hypocaloric diet (de Luis, Izaola, et al, 2018) and bariatric surgery (de Luis, García Calvo, et al, 2018) could significantly increase the blood levels of omentin‐1 in obese subjects. As known so far, this is the first report concerning the combined effects of thylakoid‐rich spinach extract supplementation and caloric restriction on circulating levels of omentin‐1 and chemerin; more human studies would clarify the subject.…”

Impact of Bariatric Surgery on Adipose Tissue Biology

“…Despite some conflicting reports in the very short term [ 146 , 147 , 149 , 150 , 156 ], circulating adiponectin levels appear to be consistently increased 1 year after BS [ 139 , 141 , 142 , 150 , 152 , 156 , 158 , 168 ]. For its part, omentin was found to be increased as early as 24 h after BPD [ 172 ], and such a change is maintained for up to 1 year [ 172 , 173 ]. Apelin, a multifaceted biomarker [ 174 ], and vaspin, an insulin-sensitizing adipokine [ 175 ], are less investigated adipokines that showed a short-term reduction after BS.…”

A Randomized Trial with Two Hypocaloric Diets with Different Lipid Profiles and Effects on Serum Omentin-1 Levels in Obese Subjects

“…Finally, supplementation with vitamin D in a hypocaloric diet in obese adults for 2 months also failed to modify omentin-1 levels (27). Nevertheless, the increase in omentin-1 after the great weight losses demonstrated after bariatric surgery is more consistent throughout the different studies in the literature (27)(28)(29)(30).…”