A Prospective Randomized Controlled Study of Oral Tranexamic Acid for Preventing Postinflammatory Hyperpigmentation After Q-Switched Ruby Laser

Choi

Journal of Dermatological Treatment

et al. 2011

100

Section: Discussionmentioning

confidence: 98%

Role of oral tranexamic acid in melasma patients treated with IPL and low fluence QS Nd:YAG laser

Choi

Journal of Dermatological Treatment

et al. 2011

100

Journal of Craniofacial Surgery

“…In the latter series, the benefit of TXA was most obvious following modified radical neck dissection, although the comparison involved a small number of cases (6 TXA versus 10 controls) and statistical significance was not stated. 37 Although TXA was used in aesthetic medicine for the management of melasma, 39,40,42 the surgical efficacy in minimizing transfusion requirements and reducing blood loss and/or drain output in an aesthetic population remains untested.…”

Section: Discussionmentioning

confidence: 99%

“…Four clinically heterogeneous trials were identified in the area of aesthetic surgery, involving 365 patients [39][40][41][42] but all 4 assessed the use of TXA as a lightening agent for melasma in oriental and/or Asian skin, including 2 studies investigating the use of oral TXA in conjunction with laser depigmentation. Tranexamic acid has also been reported as a constituent of tumescent solution in hair transplant surgery 43 and liposuction.…”

Section: Aestheticmentioning

confidence: 99%

The Efficacy and Safety of Tranexamic Acid in Cranio-Maxillofacial and Plastic Surgery

Murphy

Glass

Jain

2016

The antifibrinolytic drug tranexamic acid (TXA) is effective in reducing blood loss and transfusion requirements in other fields of elective surgery and its use is emerging in a number of plastic surgical subspecialties. This systematic review and meta-analysis evaluates the current evidence for the efficacy and safety of TXA in craniomaxillofacial, head and neck, breast, aesthetic, burns, and reconstructive microsurgery. We searched PubMed, EMBASE, Medline, The Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials for randomized controlled trials of TXA in plastic surgery. Studies were analyzed using standard methodology. A total of 7965 records were screened, of which 14 met the inclusion criteria. Seven were suitable for meta-analysis. In craniofacial surgery, TXA was associated with a mean reduction in blood loss of 18.2 mL/kg (P = 0.00001) and a mean reduction in blood transfusion of 8.7 mL/kg (P = 0.0001). In orthognathic surgery, TXA was associated with a mean reduction in blood loss of 156 mL (P = 0.001). Tranexamic acid may also have a role in reducing drainage output volumes in oncological breast excision and lymph node dissection of the neck. Level-1 evidence for efficacy in aesthetic surgery, burns, and reconstructive microsurgery is lacking. Although no reported complications were attributable to TXA, there remain no phase IV trials published. Level-1 evidence supports the use of TXA in craniofacial and orthognathic surgery. There exists an unmet need for studies in areas, including burns, aesthetic surgery, and reconstructive microsurgery. Phase IV trials in areas of proven efficacy are also required.

“…In this study, the melanin content in skin was calculated according to the reflectance at 660 and 880 nm which was determined with the principle of the widely used skin evaluator Mexameter® MX18 (Courage + Khazaka electronic GmbH, Köln, Germany). 18,19 It is well known that whole blood has a weak absorption in the wavelength range of dark red or NIR light, so the measured reflectance at 660 and 880 nm could indicate the melanin content in skin. Actually, other wavelengths, such as 650 and 710 nm could also be effective for the evaluation of melanin.…”

Section: Discussionmentioning

confidence: 99%

Reflectance spectroscopy for noninvasive evaluation of hair follicle stage

et al. 2014

Abstract. Hair follicle offers an excellent model for systems biology and regenerative medicine. So far, the stages of hair follicle growth have been evaluated by histological examination. In this work, a noninvasive spectroscopy was proposed by measuring the diffuse reflectance of mouse skin and analyzing the melanin value. Results show that the skin diffuse reflectance was relatively high when hair follicles were at the telogen stage and at the beginning of the anagen stage, and decreased with the progression of the anagen stage. When the hair follicle entered into the catagen stage, the diffuse reflectance gradually increased. The changes in the melanin content of skin had contrary dynamics. Substages of the hair follicle cycle could be distinguished by comparing the changes in melanin value with the histological examination. This study provided a new method for noninvasive evaluation of the hair follicle stage, and should be valuable for basic and therapeutic investigations on hair regeneration.