A prospective, observational study of osteoporosis in men

Kotwal, Narendra; Upreti, Vimal; Nachankar, Amit; Kumar, Ketan

doi:10.4103/ijem.ijem_414_16

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…Some previous studies demonstrated that hypogonadism was the cause of male osteoporosis (6.9%–58%) [ 42 , 43 , 44 , 45 , 46 , 47 ] ( Table 1 ). However, these studies are limited by their small sizes and various potential biases.…”

Section: The Relationship Between Hypogonadism and Bmd In Humansmentioning

confidence: 99%

Testosterone and Bone Health in Men: A Narrative Review

Shigehara

Izumi

Kadono

et al. 2021

JCM

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Bone fracture due to osteoporosis is an important issue in decreasing the quality of life for elderly men in the current aging society. Thus, osteoporosis and bone fracture prevention is a clinical concern for many clinicians. Moreover, testosterone has an important role in maintaining bone mineral density (BMD) among men. Some testosterone molecular mechanisms on bone metabolism have been currently established by many experimental data. Concurrent with a decrease in testosterone with age, various clinical symptoms and signs associated with testosterone decline, including decreased BMD, are known to occur in elderly men. However, the relationship between testosterone levels and osteoporosis development has been conflicting in human epidemiological studies. Thus, testosterone replacement therapy (TRT) is a useful tool for managing clinical symptoms caused by hypogonadism. Many recent studies support the benefit of TRT on BMD, especially in hypogonadal men with osteopenia and osteoporosis, although a few studies failed to demonstrate its effects. However, no evidence supporting the hypothesis that TRT can prevent the incidence of bone fracture exists. Currently, TRT should be considered as one of the treatment options to improve hypogonadal symptoms and BMD simultaneously in symptomatic hypogonadal men with osteopenia.

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Section: The Relationship Between Hypogonadism and Bmd In Humansmentioning

confidence: 99%

Testosterone and Bone Health in Men: A Narrative Review

Shigehara

Izumi

Kadono

et al. 2021

JCM

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“…In aging population, morbidity and mortality from hip fractures are higher in men than in women with fatality rates, among over 75 years is 20.7% in men vs. 7.5% in women [7]. The causes of osteoporosis in men are relative to hormonal, genetics, environmental, other specific disease factors, and along 50% of men with secondary osteoporosis [6,8]. The three primary causes of secondary osteoporosis in men are glucocorticoid excess, hypogonadism, and alcohol abuse.…”

Section: Introductionmentioning

confidence: 99%

The effect of deer antler from East Kalimantan to increase trabecular bone density and calcium levels in serum on osteoporotic mice

Widyowati

Suciati

Haryadi

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Glucocorticoid-induced osteoporosis (dexamethasone) is a primary cause of secondary osteoporosis by the decreasing formation and increasing resorption activities. Previously, the in vitro study showed that 70% ethanol and aqueous extract of deer antler have increased alkaline phosphatase in osteoblast cell that known as marker of bone formation. The mind of this study is to analyze the effect of deer antlers in increasing the bone trabecular density of osteoporosis-induced male mice. Methods This study used a post-test control group design. A total of 54 healthy male mice were randomly divided to nine groups, i.e., healthy control, osteoporotic, positive control, 70% ethanol (4, 8, and 12 mg/kg BW), and aqueous extracts (4, 8, and 12 mg/kg BW) of deer antler groups. All of the interventions were given 1 mL of test sample for 4 weeks orally. The bone densities were determined using histomorphometry by Image J and Adobe Photoshop. The statistical data were performed using SPSS 23 and statistical significance was set at p<0.05. Results The results showed that alendronate group, 70% ethanol, and aqueous extract groups increased bone density and calcium levels in serum (p<0.05) compared to osteoporotic group in dose dependent manner. It indicated that 70% ethanol and aqueous extract of deer antler stimulating bone turnover and aqueous extract showed the highest. Conclusions Dexamethasone induction for 4 weeks caused osteoporotic mice and the administration of 70% ethanol and aqueous extracts of deer antler from East Kalimantan increased trabecular bone density and calcium levels in dose dependent manner.

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“…[1] Its deficiency leads to secondary hyperparathyroidism, increased bone turnover, and bone loss, predisposing individuals to osteoporosis and osteoporotic fractures. [23] The optimal serum level of vitamin D required for maintenance of bone health. [4] However, the appropriate dosage for replacement therapy is still debatable.…”

Section: Introductionmentioning

confidence: 99%

An open-label, randomized, 10 weeks prospective study on the efficacy of vitamin D (daily low dose and weekly high dose) in vitamin D deficient patients

Singh¹,

Misra²,

Singh³

et al. 2019

J Family Med Prim Care

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Background: Vitamin D is an important vitamin required to maintain normal skeletal as well as nonskeletal functions. The daily supplementation of vitamin D not only have poor adherence to the regimen but also of doubtful efficacy in deficient patients. Objectives: The aim of this study was to compare the effect of oral high-dose vitamin D regimens (60,000 IU weekly) and daily low-dose vitamin D regimen of 1000 IU in mitigating symptoms and increase in serum levels of vitamin D in patients with hypovitaminosis D. Materials and Methods: A total of 90 patients aged 18–60 years with vitamin D deficiency (serum levels < 30 ng/mL) were enrolled. A total of 38 subjects received 60,000 IU of vitamin D weekly with 500 mg/day calcium and 40 subjects received a dose of 1000 IU of vitamin D daily with 500 mg/day calcium for 10 weeks. Baseline and follow-up total serum vitamin D levels and improvement in symptoms were measured within and between groups. Results: For high-dose vitamin D (60,000 IU weekly), the increase in mean serum vitamin D levels from baseline was 28.33 ng/mL over 10 weeks’ treatment period; whereas for the low-dose group (1000 IU daily) the mean increment in serum vitamin D was 6.79 ng/mL for the same period. The mean difference in increase in serum vitamin D between two groups was highly significant ( P < 0.001). In both the groups, decrease in myalgia as evaluated on visual analog scale was observed after 10 weeks. Conclusions: High-dose vitamin D (60,000 IU weekly) regimen rapidly normalized 25(OH) D levels and ensure symptomatic relief earlier than daily dosing of 1000 IU vitamin D for same duration.

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A prospective, observational study of osteoporosis in men

Cited by 11 publications

References 17 publications

Testosterone and Bone Health in Men: A Narrative Review

Testosterone and Bone Health in Men: A Narrative Review

The effect of deer antler from East Kalimantan to increase trabecular bone density and calcium levels in serum on osteoporotic mice

An open-label, randomized, 10 weeks prospective study on the efficacy of vitamin D (daily low dose and weekly high dose) in vitamin D deficient patients

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