A prospective follow-up study of 570 patients with oral lichen planus: Persistence, remission, and malignant association

Silverman, Sol; Gorsky, Meir; Lozada‐Nur, Francina

doi:10.1016/0030-4220(85)90210-5

Cited by 345 publications

(230 citation statements)

References 11 publications

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“…Various clinical classifications of oral lichen planus have been proposed. These classifications include that suggested by Silverman, who distinguishes three types: reticular, atrophic and erosive (6). The reticular form usually appears symmetrically on the buccal mucosa and presents few symptoms (6).…”

Section: Introductionmentioning

confidence: 99%

“…These classifications include that suggested by Silverman, who distinguishes three types: reticular, atrophic and erosive (6). The reticular form usually appears symmetrically on the buccal mucosa and presents few symptoms (6). It is common to observe the atrophic form at the buccal, lingual and/or gingival level, with the latter appearing in the form of desquamative gingivitis (1).…”

Section: Introductionmentioning

confidence: 99%

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Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Fernández-González

R²,

Reboiras-López³

et al. 2011

Med Oral

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Objectives: To highlight the most characteristic histopathological findings of oral lichen planus and their correlation with the clinical manifestations and forms. Study design: We performed a retrospective study of 50 biopsied and diagnosed cases of oral lichen planus obtained over a period of 11 years, spanning from May 1998 to April 2009. We analyzed the age and sex of the patient, type of lichen planus, location and different histopathological findings, comparing them with the clinical lesions. Results: Seventy eight percent of the patients are female and 22% are male, with an average age of 56.06 years for both sexes. The most frequent clinical form is reticular, present in 78% of the cases, and the most common location is the buccal mucosa, present in 70% of the patients. Hydropic degeneration of the basal layer and lymphocytic infiltration in the subepithelial layer are observed in the entire sample. Signs of atypia were identified in 4% of the cases, but without dysplasic features. Other common histological findings were the presence of necrotic keratinocytes (92%), hyperplasia (54%), hyperkeratosis (66%), acanthosis (48%), and less frequently, serrated ridges (30%) and the presence plasma cells (26%). Conclusions: Oral lichen planus is a disease that is more common in women, usually appearing in the fifth and sixth decades of life. The most common clinical form is reticular, manifesting mainly in the buccal mucosa. Histological findings characteristic of oral lichen planus include hydropic degeneration of the basal layer, lymphocytic infiltration in the subepithelial layer and the absence of epithelial dysplasia; however, it is also frequent to observe hyperplasia phenomena at the epithelial level, hyperkeratosis, acanthosis and the presence of necrotic keratinocytes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Fernández-González

R²,

Reboiras-López³

et al. 2011

Med Oral

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“…Différentes formes cliniques existent et certains auteurs proposent de classer la pathologie en lichen plan réticulaire, atrophique et érosif [54].…”

Section: Implants Et Lichen Plan Buccalunclassified

Implantologie et pathologies de la muqueuse buccale : une revue de la littérature

Moreau

Renoux

Ejeil

2015

Med Buccale Chir Buccale

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Résumé -Introduction : L'essor de l'implantologie au cours des dernières années a conduit à une augmentation du champ de ses indications, repoussant notamment les contre-indications liées aux terrains pathologiques des patients. Cet article propose une revue de la littérature et une mise au point sur l'implantologie dans un contexte de pathologies de la muqueuse buccale. Méthodologie : À partir d'une recherche bibliographique sur la base de données MEDLINE sans limite de période, les articles traitant de l'implantologie chez des patients atteints de pathologies de la muqueuse buccale ont été étudiés. Résultats : L'implantologie chez ces patients a été peu décrite. Les données de cette revue de la littérature tendent à mettre en évidence un apport indéniable de la mise en place d'implants chez les patients atteints de pathologies de la muqueuse buccale. Discussion : Historiquement considérées comme des contre-indications à la pose d'implants, ces pathologies ne doivent plus aujourd'hui être considérées comme un frein à une réhabilitation prothétique implanto-portée. Conclusion : Toutefois, une maintenance et une hygiène rigoureuses doit être instaurée afin de contrôler les implants et l'éventuelle réactivation de la pathologie.Abstract -Implantology and oral mucosal lesions: a literature review. Introduction: Recent developments in implantology have led to an extension of its indications, especially regarding special care patients. This paper offers a review of the literature on the subject of implantology in cases of oral mucosal lesions. Methods: A review of the literature was performed using MEDLINE, without a date range, searching for articles describing oral implant treatments in patients with oral mucosal alterations. Results: Few cases of oral implant treatments in such patients are described. The results of the literature review showed that oral implant treatments greatly enhance the quality of life of these patients. Discussion: Although these pathologies used to be considered contraindications to dental implant placement, recent data shows the feasibility of such treatments. Conclusion: Nonetheless, both strict oral hygiene and regular maintenance are essential to intercept any potential pathology reactivation.

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“…Since the World Health Organization (WHO) developed diagnostic criteria for OLP that included clinical and histopathological standards in 1978 (7), certain authors have considered OLP to be a precancerous lesion based on retrospective and prospective epidemiological data (8)(9)(10)(11). Van der Meij et al proposed a modification of the WHO diagnostic criteria for OLP to include the definition of an entity referred to as 'oral lichenoid lesion' (OLL) and to differentiate between OLL and OLP clinically and histopathologically.…”

Section: Introductionmentioning

confidence: 99%

Myeloid cell leukemia-1 is a molecular indicator for malignant transformation of oral lichen planus

Shin

Seo

et al. 2016

Oncology Letters

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Abstract. Oral lichen planus (OLP), characterized by a chronic mucocutaneous inflammatory condition, is a common disease of the oral cavity. Retrospective and prospective epidemiological data suggest that OLP is considered to have malignant potential. However, it is unclear as to which types of molecules may cause malignant transformation of OLP. In the present study, the presence of myeloid cell leukemia-1 (Mcl-1) and B-cell lymphoma-2 (Bcl-2) was studied by western blot analysis in 11 OLP and three normal oral mucosa (NOM) samples and in two human oral cancer cell lines. The functional role of Mcl-1 in oral cancer cells was analyzed using a trypan blue exclusion assay and soft agar assay. Mcl-1 was strongly expressed in the OLP and the two oral cancer cell lines compared with NOM, whereas Bcl-2 was not. Sorafenib and mithramycin A decreased cell viability in MC-3 and HSC-3 oral cancer cells and at same concentration they reduced the expression level of Mcl-1 in the two cell lines. The two chemicals affected Mcl-1 protein and significantly inhibited neoplastic cell transformation in the two cell lines. We suggest that the malignant potential of OLP may be associated with the expression of Mcl-1, and that downregulation of Mcl-1 may prevent malignant transformation of OLP to oral cancer.

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A prospective follow-up study of 570 patients with oral lichen planus: Persistence, remission, and malignant association

Cited by 345 publications

References 11 publications

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Histopathological findings in oral lichen planus and their correlation with the clinical manifestations

Implantologie et pathologies de la muqueuse buccale : une revue de la littérature

Myeloid cell leukemia-1 is a molecular indicator for malignant transformation of oral lichen planus

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