A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis

Jun, Baek Gyu; Park, Won Young; Park, Eui Ju; Jang, Jae Young; Jeong, Soung Won; Lee, Sae Hwan; Kim, Sang Gyune; Cha, Sang‐Woo; Kim, Young Seok; Cho, Young Deok; Kim, Hong Soo; Kim, Boo Sung; Jin, So Young; Park, Suyeon

doi:10.1371/journal.pone.0182784

Cited by 37 publications

(30 citation statements)

References 42 publications

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“…As NAFLD/NASH can lead to serious liver‐ and cardiovascular related complications, this should be assessed in all pNET patients approximately 1 year after pancreatic resection. Controlled attenuated parameter (CAP) has proven to be an accurate non‐invasive alternative to liver biopsy for diagnosis of NAFLD/NASH and could be used in the pre‐ and postoperative assessment of hepatic steatosis. Therefore we suggest that further research with long‐term follow‐up should focus on prospective pre‐ and postoperative liver evaluation with CAP.…”

Section: Discussionmentioning

confidence: 99%

New onset non‐alcoholic fatty liver disease after resection of pancreatic neuroendocrine tumors

Mackay

Genc

Takkenberg

et al. 2018

Journal of Surgical Oncology

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Background and ObjectivesNon‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatis (NASH) may occur after pancreatic resection due to exocrine pancreatic insufficiency (EPI). Patients with long‐term survival, such as after pancreatic neuroendocrine tumor (pNET) resection, are at risk of NAFLD/NASH. We aimed to determine the incidence and risk factors for new onset NAFLD/NASH and EPI after pNET resection.MethodsRetrospective monocenter cohort study. Patients who underwent pNET resection (1992‐2016) were assessed for new onset NAFLD/NASH and EPI. Postoperative NAFLD/NASH was determined by a blinded abdominal radiologist, who compared pre‐ and postoperative imaging.ResultsOut of 235 patients with pNET, a total of 112 patients underwent resection and were included with a median follow‐up of 54 months. New onset NAFLD/NASH occurred in 20% and EPI in 49% of patients. Multivariate analysis showed that the only risk factor for new onset NAFLD/NASH was recurrent disease (OR 4.4, 95% CI 1.1‐16.8, P = 0.031), but not EPI (OR 0.94, 95% CI 0.3‐2.8, P = 0.911). The only risk factor for EPI was pancreatoduodenectomy (OR 4.3, 95% CI 1.4‐13.7, P = 0.012).ConclusionsNew onset NAFLD/NASH is occasionally found after pNET resection, especially in patients with recurrent disease, but is not related to EPI.

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Section: Discussionmentioning

confidence: 99%

New onset non‐alcoholic fatty liver disease after resection of pancreatic neuroendocrine tumors

Mackay

Genc

Takkenberg

et al. 2018

Journal of Surgical Oncology

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“…We also lacked cross sectional imaging such as MRI, which has the highest sensitivity for detecting hepatic steatosis [42]. However, CAP is an FDA-approved ultrasound-based modality for characterizing the presence and severity of hepatic steatosis, and the threshold used to define steatosis has shown high correlation with histologically-confirmed steatosis [26]. In the current study there were too few women to evaluate ethnic differences in liver biopsy measures of NASH, however, existing data on biopsy-confirmed NASH in PCOS are currently quite limited.…”

Section: Discussionmentioning

confidence: 99%

“…TE-CAP (FibroScan®, Echosens, Paris, France) is a Food and Drug Administration (FDA)-approved, non-invasive method for evaluating hepatic fibrosis and steatosis that is validated in NAFLD [25]. Our secondary outcome was presence of steatosis by CAP defined as CAP score > 250 dB/m, given the high concordance of this threshold with biopsy-confirmed steatosis [26]. …”

Section: Methodsmentioning

confidence: 99%

The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome

Sarkar

Terrault

Duwaerts

et al. 2018

COGO

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Polycystic Ovary Syndrome (PCOS) affects 10-15% of reproductive age women and is a recognized risk factor for nonalcoholic fatty liver disease (NAFLD). The more severe form of NAFLD, known as nonalcoholic steatohepatitis (NASH), results in liver inflammation with or without fibrosis, and is now a leading cause of cirrhosis. Ethnic differences are apparent in NAFLD, with higher prevalence in Hispanics, although the role of Hispanic ethnicity on risk for NAFLD/NASH in women with PCOS is not known. Objective: The aim of this study was to evaluate ethnic differences in the prevalence and risk of NAFLD/NASH in women with PCOS. Study Design: Among PCOS women followed in a large academic medical center the association of Hispanic ethnicity with elevated biomarkers of NASH, including plasma cytokeratin 18 (CK18) M30 fragments and/or ALT levels (n=303), was assessed. Prevalence of hepatic steatosis by Controlled Attenuation Parameter (CAP) imaging was also evaluated in a subset of PCOS women (n=35). Results: The median cohort age (n=303) was 28 years (IQR 8), and 15.5% (n=47) were Hispanic, the majority of whom reported white race (94%). Most Hispanic women had hepatic steatosis on imaging, which was markedly higher than in non-Hispanics (83% vs 24%, p=0.005). Approximately 17% of PCOS women had elevated ALT or elevated CK18, which was more common in Hispanics than non-Hispanics, at 34% vs 14%, respectively, p=0.002. On univariate analysis, Hispanic ethnicity was associated with two-fold higher odds of NASH (OR 2.0, 95% CI 1.0-3.9, p=0.038), and the association persisted after adjustment for HOMA-IR and waist circumference (AOR 3.1, 95% CI 1.1-8.9, p=0.034). Conclusion: NAFLD/NASH is an important condition to be considered by PCOS providers and Hispanic women with PCOS are a particularly high-risk group that may warrant routine screening.

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“…CAP is only influenced by the steatosis stage. Several reports have stated cut-off values for CAP [13]. The cut-off value of CAP for detecting hepatic steatosis of ≥5% is 247-250 dB/m, and that of ≥10% is 210-283 dB/m; this value differs depending on the reports.…”

Section: Discussionmentioning

confidence: 99%

Transient elastography: a novel, non-invasive method for the evaluation of liver stiffness and controlled attenuation parameter in cows

Ono

Imamura

Irie

et al. 2020

The Journal of Veterinary Medical Science

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This study investigated the use of transient elastography (TE) as a tool for the noninvasive evaluation of liver stiffness and controlled attenuation parameter (CAP) in cows. A total of cows were used for this study. After the liver was located and subcutaneous tissue thickness was checked by means of ultrasonography, liver stiffness and CAP were measured using TE. At least 10 measurements were taken per individual cow. In addition, intraclass correlation coefficients were calculated for intra-rater and two-rater inter-rater reliability of liver stiffness and CAP measurement, and were evaluated. Of the 85 cows, 61 (71.8%) were measurable owing to their significantly less body weight and subcutaneous tissue thickness compared with those of unmeasurable cows. Liver stiffness showed no significant differences among sexes, ages, or breeds. CAP showed no significant differences among sexes and breeds. Intra-and inter-rater reliabilities for liver stiffness and CAP were almost perfect. Both liver stiffness and CAP could be quantitatively evaluated with good reproducibility in cows using TE, and CAP increased with the growth of the cows. However, evaluation was not possible in obese cows or cows with high values for subcutaneous tissue thickness or body weight.

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A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis

Cited by 37 publications

References 42 publications

New onset non‐alcoholic fatty liver disease after resection of pancreatic neuroendocrine tumors

New onset non‐alcoholic fatty liver disease after resection of pancreatic neuroendocrine tumors

The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome

Transient elastography: a novel, non-invasive method for the evaluation of liver stiffness and controlled attenuation parameter in cows

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