A Prospective Analysis of Low‐Grade Gastric MALT Lymphoma after <i>Helicobacter pylori</i> Eradication

Hong, Seong Soo; Jung, Hwoon‐Yong; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Oh, Tae Hoon; Jo, Ji-Yun; Kim, Kyu-Jong; Byeon, Jeong‐Sik; Myung, Seung‐Jae; Yang, Suk‐Kyun; Hong, Weon‐Seon; Kim, Jin-Ho; Min, Young Il

doi:10.1111/j.1523-5378.2006.00460.x

Cited by 49 publications

(51 citation statements)

References 19 publications

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“…A substantial portion of relapses were also reported to occur in a transient fashion, such that the histological recurrence spontaneously disappeared without any treatment (Nakamura et al 2005;Hong et al 2006). Hence, it is a matter of dispute whether transient relapse of gastric MALT lymphoma after eradication represents potentially missed remnant foci of initial lymphoma by sampling error or true relapse (Hong et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Gastric Mucosa-Associated Lymphoid Tissue Lymphomas after Helicobacter pylori Eradication Therapy

Terai

Iijima

Kato

et al. 2008

Tohoku J. Exp. Med.

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Mucosa-associated lymphoid tissue (MALT) lymphomas are localized primarily in the gastrointestinal tract and are characterized by an indolent nature and favorable outcome with specifi c therapy. Gastric MALT lymphomas are closely linked to Helicobacter pylori (H. pylori) infection, for which eradication therapy is recognized as an effective primary treatment for the disease. However, there is little information about long-term outcomes after the therapy. In the present study, we elucidated the long-term outcomes of 74 patients (70 H. pylori-positive and 4 negative cases) followed up by endoscopy at least 12 months after exclusive eradication therapy alone. The median follow-up period was 46 months. When the remission status was estimated at the time point of 12 months post-eradication, the numbers of patients with complete remission (CR), histologically residual disease with macroscopic normalization (hRD), partial remission with more than 50% tumor reduction (PR) or no response (NR) were 56, 12, 2 and 4, respectively. During follow-ups of over 12 months post-eradication, 11 of the 12 hRD cases were belatedly induced to CR but one CR case histologically relapsed into hRD. One of the 2 PR cases eventually turned into hRD 20 months later. Therefore, 66 CR, 3 hRD, 1 PR, and 4 NR cases (including 3 H. pylorinegative) were identifi ed at the last follow-up of the present study. All 74 patients were followed up without any second-line therapies, but none exhibited disease progression. Thus, the long-term outcome of localized gastric MALT lymphoma after H. pylori eradication therapy was favorable. A watch and wait strategy may be a reasonable approach for hRD since the majority might be in the process of turning into delayed CR. gatric MALT lymphoma; H. pylori eradication; long-term outcome; complete remission; radiotherapy.Tohoku

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Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Gastric Mucosa-Associated Lymphoid Tissue Lymphomas after Helicobacter pylori Eradication Therapy

Terai

Iijima

Kato

et al. 2008

Tohoku J. Exp. Med.

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“…Helicobacter pylori (H. pylori) has been etiologically linked to both GC and PGL [5][6][7][8]. Several studies showed that H. pylori is associated with GC and PGL in developed countries [6,9].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Helicobacter pylori and CagA Antibody in Patients with Gastric Neoplasms and Controls: The Indian Enigma

et al. 2008

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“…In contrast to primary gastric NHL, secondary involvement of the GI tract by nodal NHL, which occurs in 20% to 60% of newly diagnosed cases, reflects disseminated disease that necessitates systemic treatment strategies [9,10] . Studies analyzing the incidence of secondary gastric NHL revealed a great discrepancy between the frequencies of GI involvement diagnosed before treatment as opposed to postmortem findings.…”

Section: Introductionmentioning

confidence: 99%

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

Todorović¹,

Balint²,

Jevtic³

et al. 2008

WJG

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AIM:To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy. METHODS:Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages Ⅰ to Ⅳ) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo. RESULTS:Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%. CONCLUSION:Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.

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A Prospective Analysis of Low‐Grade Gastric MALT Lymphoma after Helicobacter pylori Eradication

Abstract: The status of H. pylori is the most important risk factor affecting recurrence. Therefore, adequate eradication regimen and accurate regular evaluation for H. pylori status are needed during follow up of primary gastric low-grade B-cell MALT lymphoma.

Cited by 49 publications

References 19 publications

Long-Term Outcomes of Gastric Mucosa-Associated Lymphoid Tissue Lymphomas after Helicobacter pylori Eradication Therapy

Long-Term Outcomes of Gastric Mucosa-Associated Lymphoid Tissue Lymphomas after Helicobacter pylori Eradication Therapy

Frequency of Helicobacter pylori and CagA Antibody in Patients with Gastric Neoplasms and Controls: The Indian Enigma

Primary gastric mucosa associated lymphoid tissue lymphoma: Clinical data predicted treatment outcome

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