A proposed terminology for the adenovirus antigens and virion morphological subunits

Ginsberg, Harold S.; Pereira, H. G.; Valentine, R. C.; Wilcox, Wesley C.

doi:10.1016/0042-6822(66)90271-6

Cited by 148 publications

(42 citation statements)

References 6 publications

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“…The terminology proposed by Ginsberg et al (1966) for the major capsid components (hexon, penton, fibre) is used.…”

Section: Methodsmentioning

confidence: 99%

Ultrastructural and Immunofluorescence Studies of Early Events in Adenovirus-HeLa Cell Interactions

Patterson¹,

Russell²

1983

Journal of General Virology

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SUMMARYScanning electron microscopy and immunofluorescence techniques show that the attachment of adenovirus type 5 to HeLa cells is followed by a temperature-dependent redistribution of virus particles on the cell surface. Metabolic inhibitors and cytochalasin B, a drug that impairs microfilament function, blocked this redistribution. Transmission electron microscopy studies demonstrated that inhibition of redistribution was paralleled by an inhibition of virus internalization. In further experiments virus and cells were incubated at 4 °C and then treated with adenovirus 'soluble' antigens to block unoccupied virus receptors. On warming these preparations to37 °C, the internalization of attached virions was found to be impaired. It is proposed that energy-dependent redistribution of attached adenovirus particles on the cell surface facilitates entry by bringing virions into contact with sufficient receptors to allow internalization.

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“…The terminology proposed by Ginsberg et al (1966) for the major capsid components (hexon, penton, fibre) is used.…”

Section: Methodsmentioning

confidence: 99%

Ultrastructural and Immunofluorescence Studies of Early Events in Adenovirus-HeLa Cell Interactions

Patterson¹,

Russell²

1983

Journal of General Virology

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“…The 240 capsomers which formed the triangular faces and edges, each of which was surrounded by six neighbours, were subsequently given the name hexons (Ginsberg et al, 1966). Single capsomeres located at the vertices and surrounded by five neighbours were called pentons (Ginsberg et al, 1966). The pentons of the human viruses were found to be complex consisting of an antenna like projection, the fibre, and the vertex capsomer or penton base (Valentine and Pereira, 1965).…”

Section: Properties Of Fowl Adenovirusesmentioning

confidence: 99%

Section: Properties Of Fowl Adenovirusesmentioning

confidence: 99%

“…Pereira et al (1959) demonstrated three types of antigen using immuno-electrophoresis, designated A, B and C. The same antigens were separated by elution from DEAE-cellulose by Wilcox and Ginsberg (1961) and were called E (early eluting), L (late eluting), and T (toxin). Ginsberg et al (1966) proposed that these antigens be named hexon (antigen A or L), penton (antigen B or toxin) and fibre (antigen C or E). The component now called the hexon has been identified as the carrier of the group-specific antigen (Allison et al, 1960) and the antigenic factor responsible for group reactivity was designated a (Pereira 1960).…”

Section: Antigens and Classificationmentioning

confidence: 99%

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Avian adenoviruses ‐ a review

1977

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“…Virus was produced in KB or HeLa The terminology of the polypeptides is that suggested by Anderson et al (1973). The terms hexon, penton base and fibre are also used (Ginsberg et aL, 1966) to describe the capsomeres formed by polypeptides II, Ill and IV respectively. cells growing in suspension, and purified by fluorocarbon extraction followed by velocity and equilibrium CsC1 gradient centrifugation.…”

Section: Viruses and Cellsmentioning

confidence: 99%

Nucleic Acid-binding Properties of Adenovirus Structural Polypeptides

Russell¹,

Precious²

1982

Journal of General Virology

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SUMMARYThe ability of adenovirus structural polypeptides to bind nucleic acids was assessed by separating the polypeptides on SDS-polyacrylamide gels, transferring them electrophoretically to nitrocellulose and probing with 32p-labelled nucleic acids. Polypeptides IVa2, V, VI and VII, as well as trace amounts of pVII and a polypeptide of apparent mol. wt. 40 x 103 were able to bind label under these conditions. Labelling was also detected with a smaller polypeptide, possibly related to the cleavage products of pVII and/or pVI. The binding of DNA to polypeptide VI appeared to be more sensitive to detergents than the others. No sequence specificity could be detected in the DNA binding.

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A proposed terminology for the adenovirus antigens and virion morphological subunits

Cited by 148 publications

References 6 publications

Ultrastructural and Immunofluorescence Studies of Early Events in Adenovirus-HeLa Cell Interactions

Ultrastructural and Immunofluorescence Studies of Early Events in Adenovirus-HeLa Cell Interactions

Avian adenoviruses ‐ a review

Nucleic Acid-binding Properties of Adenovirus Structural Polypeptides

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