A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant

Levine, Seymour; Saltzman, Arthur

doi:10.1016/j.vascn.2006.05.009

Cited by 33 publications

(18 citation statements)

References 20 publications

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“…Orbans et al, used a single low dose of tyloxapol (40 mg/body) and observed that the levels of serum lipids elevated to maximum level at 6 h but fell down after 24 hour [27]. Conversely, Levin and Saltzman induced sustained hyperlipidemia by three injection of detergent per week [28]. The kinetics of plasma lipids observed in the current study is confirmed by the pathological changes of the liver reported by Trout and Viles [29].…”

Section: Long Term Kinetic Of Plasma Lipids Following Tyloxapol Injecsupporting

confidence: 84%

The Long Term Kinetic of Plasma Lipids and Lipoproteins in Tyloxapol Injected Rats

Rasouli

Tahmouri

Mosavi-Mehr

2016

JCDR

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Section: Long Term Kinetic Of Plasma Lipids Following Tyloxapol Injecsupporting

confidence: 84%

The Long Term Kinetic of Plasma Lipids and Lipoproteins in Tyloxapol Injected Rats

Rasouli

Tahmouri

Mosavi-Mehr

2016

JCDR

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“…Alternatively HL can be induced by dietary means (e.g. chronic feeding of a high fat diet) (11,13,40,43) or by treatment with compounds such as Triton (14,26) or poloxamer 407 (P407) (16). P407, a non-ionic synthetic copolymer surfactant, provides an attractive means of inducing HL because of its rapid onset and seeming lack of overt toxicity; within 24 h of its intraperitoneal (i.p.)…”

Section: Introductionmentioning

confidence: 99%

The Single Dose Poloxamer 407 Model of Hyperlipidemia; Systemic Effects on Lipids Assessed Using Pharmacokinetic Methods, and its Effects on Adipokines

Chaudhary

Brocks

2013

J Pharm Pharm Sci

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-Purpose:The induction of hyperlipidemia using poloxamer 407 (P407) is gaining use for studying the effect of the condition on drug pharmacokinetics. Although a single intraperitoneal dose of P407 causes a rapid onset of hyperlipidemia, the initial lipid concentrations are much higher than seen in humans. The hyperlipidemia is also reversible in nature. Here, pharmacokinetic methods were used to assess the P407 dose response on serum lipids, adipokines and cytokines. Methods: Single 0.5 and 1 g/kg doses of P407 were injected into rats followed by blood collection at various times for up to 12 d. Serum was assayed for lipids, selected adipokines and cytokines. Results: As expected, large increases in lipid levels were seen by 36 h after dosing. Using area under the concentration vs. time curve as a measure of systemic lipid exposure, P407 increased serum baseline corrected serum lipids in a nearly dose proportional fashion. The maximum increase in lipids was observed at ~36 h, with most lipids remaining elevated for up to ~180 h, although for the 1 g/kg dose triglyceride concentrations had still not quite returned to baseline by 12 days postdose. In addition to changes in lipids, P407 significantly increased serum leptin and decreased the serum adiponectin concentrations but did not affect cytokine levels. Conclusion: Depending on study aims, for the use of the model it may be beneficial to perform single-dose assessments at time points later than 36 h when the lipoprotein concentrations will be more similar to those seen in patient with hyperlipidemia.

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“…Throughout the study, the animals had free access to feed and water (Levine & Saltzman, 2007). The animals were divided into six groups, containing six each.…”

Section: Triton Wr-1339-induced Hyperlipidemic Animalsmentioning

confidence: 99%

Antihyperlipidemic activity ofIchnocarpus frutescensin triton WR-1339-induced and high-fat diet animals

Munisankar¹,

Pandikumar²,

Babu³

et al. 2011

Pharmaceutical Biology

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A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant

Cited by 33 publications

References 20 publications

The Long Term Kinetic of Plasma Lipids and Lipoproteins in Tyloxapol Injected Rats

The Long Term Kinetic of Plasma Lipids and Lipoproteins in Tyloxapol Injected Rats

The Single Dose Poloxamer 407 Model of Hyperlipidemia; Systemic Effects on Lipids Assessed Using Pharmacokinetic Methods, and its Effects on Adipokines

Antihyperlipidemic activity ofIchnocarpus frutescensin triton WR-1339-induced and high-fat diet animals

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