Antihyperlipidemic activity of<i>Ichnocarpus frutescens</i>in triton WR-1339-induced and high-fat diet animals

Munisankar, Saravanan; Pandikumar, P.; Babu, N. Prakash; Ignacimuthu, Savarimuthu

doi:10.3109/13880209.2011.565477

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…At present, although synthetics hypolipidemic drugs dominate the market, the toxic components of these drugs cannot be eliminated [22]. Herbal medicines are being studied and applied more to maintain our basic health because of the adverse effects of synthetic drugs and chemicals [23]. Many Mongolian medicinal plants, such as Choerospondias axillaries (Roxb.)…”

Section: Resultsmentioning

confidence: 99%

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia

Xu¹,

Wang²,

Bao³

et al. 2019

Molecules

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Artemisia integrifolia L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of A. integrifolia using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new compound, integrinol (4), together with nine known compounds, namely chamazulene (1), acetylenes (E)-2 (2), acetylenes (E)-3 (3), eugenol (5), palmitic acid (6), oleic acid (7), linoleic acid (8), linolenic acid (9) and 12,13-epoxylinolenic acid were isolated from the crude lipophilic extract of A. integrifolia. The LD50 value of the crude extract was more than 4g/kg. In Triton WR-1339-induced acute hyperlipidemia model, the crude lipophilic extract (200 mg/kg) significantly reduced total cholesterol (TC) by 70% (p ≤ 0.01) and triglycerides (TGs) by 94% (p ≤ 0.001). The fractioned compounds, such as chamazulene (1), acetylene-2 (2), and linolenic acid (9), used at 4 mg/kg dose, also significantly decreased the concentrations of TC (32%, 33% and 64%, respectively) and TGs (48%, 33% and 93%, respectively). These compounds (i.e., chamazulene, acetylenes (E)-2, and linolenic acid) were considered to be responsible for the bioactive antihyperlipidemic effect. In conclusion, the crude lipid extract of Artemisia integrifolia L could be used as a potential treatment to avert hyperlipidemia. Further studies to confirm these results in other models of hyperlipidemia (e.g., diet-induced obesity) are warranted.

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Section: Resultsmentioning

confidence: 99%

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia

Xu¹,

Wang²,

Bao³

et al. 2019

Molecules

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“…HFD was given once daily for group II, III and IV for 14 days. Treatment was given orally, 2 h after the administration of HFD once daily for 14 d [40] . At the end of the study, blood samples (0.5 ml, once) were withdrawn from retro orbital plexus.…”

Section: Antihyperlipidemic Activitymentioning

confidence: 99%

Design of Experiment Approach Based Formulation Optimization of Berberine Loaded Solid Lipid Nanoparticle for Antihyperlipidemic Activity

Sailor¹,

Ramani²,

Shah³

et al. 2021

ijps

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Sailor et al.: Formulation of solid lipid nanoparticle of berberineBerberine is an isoquinoline alkaloid possesses multitude of biological effects. However, quaternary amine cation of berberine causes poor water solubility, resulting in low bioavailability which limits its pharmacological purpose. The aim of this study was to prepare and optimize berberine loaded solid lipid nanoparticle and to evaluate its pharmacokinetic and antihyperlipidemic activity. The solid lipid nanoparticles were prepared by solvent injection method and 3 2 full factorial design was used to study the effect of concentration of polyvinyl alcohol (X 1 ) and amount of lipid (X 2 ) on particle size (Y 1 ) and entrapment efficiency (Y 2 ). The formulation was optimized using desirability function and evaluated for physicochemical, morphological, in vitro drug release and in vivo pharmacokinetic study. In vivo antihyperlipidemic activity of the formulation was also studied using high fat diet induced hyperlipidemia model. The formulation optimized by validated experimental design comprise of 1 % w/v polyvinyl alcohol, 279 mg lipid (stearic acid) to achieve particle size of 395 nm with 82.44 % entrapment efficiency. In vitro release study of berberine loaded solid lipid nanoparticle showed an initial burst release followed by slow and continuous release. Berberine loaded solid lipid nanoparticle also showed 4.13 folds improvement in relative bioavailability compared to Berberine suspension. Furthermore, Berberine loaded solid lipid nanoparticle ameliorate the levels of total cholesterol (-41 %), TG (-49 %), lipoprotein cholesterol-C (-80 %) and high-density lipoprotein cholesterol(+119 %) compared to hyperlipidemic control and also found to be better than pure drug. The prepared berberine loaded solid lipid nanoparticle are successful drug delivery system demonstrating its effectiveness in controlling hyperlipidemia due to the improved bioavailability of berberine.

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“…Saravanan et al. 129 studied the policies of Brazil, Russia, India, China, and South Africa (BRICS). BRICS have set blending targets to achieve successful development of biofuel technologies and fusing biofuel in energy markets through country policies.…”

Section: Introductionmentioning

confidence: 99%

Suitability of Biofuels Production on Commercial Scale from Various Feedstocks: A Critical Review

et al. 2022

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The growing demand for energy resources and the increase in greenhouse gas (GHG) emissions has given biofuels a lot of attention. Liquid biofuels can be a significant alternative for the transport sector. Generally, biofuels are categorized into four generations based on the feedstock. This review reports the availability, economic feasibility, and potential of biofuel feedstock in global scenario. Feedstock for first-generation biofuel comprises edible resources impacting the food supply. Second generation biofuels are based on different residual materials and nonedible fuel crops. Cost and technological limita-tions for commercialization hinders this option. Microalgae are the feedstock for third generation biofuels providing the highest yield compared to the other two generations. A scale-up to commercial level is not possible as this requires further development. Genetically modified microorganisms are used as a feedstock for fourth generation biofuel production with the highest possible yield. Third and fourth generation biofuels have potential to replace fossil fuels. This review recommends certain suggestions for sustainable biofuel production.

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Antihyperlipidemic activity ofIchnocarpus frutescensin triton WR-1339-induced and high-fat diet animals

Cited by 8 publications

References 41 publications

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia

Design of Experiment Approach Based Formulation Optimization of Berberine Loaded Solid Lipid Nanoparticle for Antihyperlipidemic Activity

Suitability of Biofuels Production on Commercial Scale from Various Feedstocks: A Critical Review

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