A Probable Case of Mucosal Fixed Drug Eruption Following Treatment with Silodosin

Abstract

A fixed drug eruption consists of erythematous patches that appear on the skin and/or mucous membranes following administration of a drug which, once healed, leaves residual hyperpigmentation. We report a 76-year-old male who presented to the Thriasio General Hospital, Athens, Greece, in 2016 with erythema, oedema and blistering of the lower lip and glans penis following the administration of silodosin for benign prostatic hyperplasia. The eruption regressed two weeks after silodosin was discontinued.Keywords: Drug Eruption; Mucous Membranes; Erythema; Blister; Silodosin; Case Report; Greece.

A first case of fixed drug eruption due to Tamsulosin

“…Fixed drug eruption is a rare type of adverse drug reaction . The clinical picture of FDE involves a well‐circumscribed erythematous patch or plaque on the skin and/or mucous membranes, with or without blisters, which recurs at the same site following the re‐administration of the responsible drug and leaves hyperpigmentation after regression . FDE may appear as solitary or multiple lesions .…”

“…This reaction has been associated with many agents, the most common being nonsteroidal anti‐inflammatory drugs, antibiotics, anticonvulsants, Paracetamol, antimalarial drugs, and Anti‐histamines (eg, Cetirizine, Hydroxyzine, Levocetirizine, Loratadine) . While most reactions are limited to characteristic hyper‐pigmented lesions, they may sometimes progress into multiple or bullous lesions with subsequent administration, hence, the need for the early identification of the culprit drug.…”

Fixed drug eruption in a patient of HLA‐B*58:01 negative after allopurinol administration: A case report

“…Fixed drug eruption was first defined by Bourns in 1889 and was characterized by recurrent similar lesions at the same locations, with each recurrence exhibiting increased severity and lasting for months and even years every time the patient is exposed to a drug with specific properties 10 . FDE may appear as solitary or multiple lesions, and the most common sites are the extremities and the male genitalia 11,12 . The skin patch test and the oral stimulation are preferred for FDE diagnosis 13 .…”

“…10 FDE may appear as solitary or multiple lesions, and the most common sites are the extremities and the male genitalia. 11,12 The skin patch test and the oral stimulation are preferred for FDE diagnosis. 13 However, the patient in our case refused the skin patch and oral stimulation and was diagnosed by histopathologic examination.…”

Signal Detection of Alpha-adrenoceptor Antagonist using the KIDS-KAERS database (KIDS-KD)

“…Tamsulosin과 치매의 관련성의 경우 위험성을 높인다는 연구와 근거가 부족 하다는 연구 등이 연이어 발표되고 있으며, 8,9) silodosin의 경 우 황반구진형 발진 등의 증례보고가 발표되었다. 10,11) 시판 중인 의약품의 기존 임상시험에서 예측하지 못한 이상 사례 및 알려진 이상사례의 새로운 양상은 자발적 부작용 보고 를 통해 수집되고 있으며, 수집된 이상사례를 통해 실마리정보 를 탐색할 수 있다. 의약품이상사례보고시스템(Korea adverse event reporting system, KAERS)은 국내 시판 중인 의약품의 자발적인 약물 이상사례 보고 시스템으로, 기존의 임상시험에 서 예측하지 못한 이상사례와 알려진 사례의 새로운 양상이 발생하였을 때 이에 대한 정보를 보고하고 관리할 수 있도록 하고 있다.…”