A probabilistic atlas of the cerebellar white matter

Baarsen, Kirsten M van; Kleinnijenhuis, Michiel; Jbabdi, Saâd; Sotiropoulos, Stamatios N.; Grotenhuis, J. A.; Walsum, A.M. van Cappellen van

doi:10.1016/j.neuroimage.2015.09.014

Cited by 84 publications

(72 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparing groups of patients and normal controls, errors in the reconstruction of the tract (caused by region of interest selection, transformation and the reconstruction algorithm itself) will be averaged out by the group-wise approach and will not have a significant impact on the outcome (van Baarsen et al 2015). Information on cerebellar structure–function correlations, as derived from large trials, may lead to modifications in the surgical approach of cerebellar lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Although anatomical verification is lacking in these studies, in general tractography seems to follow the known anatomy of the DRTT as described by textbooks (Nieuwenhuys et al 2008). Indeed, a probabilistic white matter atlas of the cerebellum, based on high-quality, high-resolution data acquired from 90 subjects participating in The Human Connectome Project will address the inter-individual variability and will be published shortly (van Baarsen et al 2015). …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction

et al. 2015

Self Cite

View full text Add to dashboard Cite

Diffusion-weighted imaging (DWI) tractography is a technique with great potential to characterize the in vivo anatomical position and integrity of white matter tracts. Tractography, however, remains an estimation of white matter tracts, and false-positive and false-negative rates are not available. The goal of the present study was to compare postmortem tractography of the dentatorubrothalamic tract (DRTT) by its 3D histological reconstruction, to estimate the reliability of the tractography algorithm in this specific tract. Recent studies have shown that the cerebellum is involved in cognitive, language and emotional functions besides its role in motor control. However, the exact working mechanism of the cerebellum is still to be elucidated. As the DRTT is the main output tract it is of special interest for the neuroscience and clinical community. A postmortem human brain specimen was scanned on a 7T MRI scanner using a diffusion-weighted steady-state free precession sequence. Tractography was performed with PROBTRACKX. The specimen was subsequently serially sectioned and stained for myelin using a modified Heidenhain–Woelke staining. Image registration permitted the 3D reconstruction of the histological sections and comparison with MRI. The spatial concordance between the two modalities was evaluated using ROC analysis and a similarity index (SI). ROC curves showed a high sensitivity and specificity in general. Highest measures were observed in the superior cerebellar peduncle with an SI of 0.72. Less overlap was found in the decussation of the DRTT at the level of the mesencephalon. The study demonstrates high spatial accuracy of postmortem probabilistic tractography of the DRTT when compared to a 3D histological reconstruction. This gives hopeful prospect for studying structure–function correlations in patients with cerebellar disorders using tractography of the DRTT.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-015-1115-7) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, functional outcome is frequently less favorable when resected lesions involve cerebellar nuclei or the vermis (Daszkiewicz et al, 2009, Robertson et al, 2006), hence the importance of eventual tractography applications. A better understanding of the connectivity of the cerebellum with the rest of the neuraxis (Milardi et al, 2016, van Baarsen et al, 2016) is progressively enlarging the indication for WMT in cerebellar lesions, as demonstrated by a recent report by Fernandes-Cabral et al who used high-definition fiber tractography for the surgical planning of a patient suffering from a Lhermitte-Duclos disease (Fernandes-Cabral et al, 2016). In this case, HDFT helped identify displaced middle cerebellar peduncle fibers around the dysplastic gangliocytoma, a distinction impossible to achieve with conventional imaging.…”

Section: Infratentorialmentioning

confidence: 99%

White matter tractography for neurosurgical planning: A topography-based review of the current state of the art

Essayed

Zhang

Unadkat

et al. 2017

NeuroImage: Clinical

182

166

View full text Add to dashboard Cite

We perform a review of the literature in the field of white matter tractography for neurosurgical planning, focusing on those works where tractography was correlated with clinical information such as patient outcome, clinical functional testing, or electro-cortical stimulation. We organize the review by anatomical location in the brain and by surgical procedure, including both supratentorial and infratentorial pathologies, and excluding spinal cord applications. Where possible, we discuss implications of tractography for clinical care, as well as clinically relevant technical considerations regarding the tractography methods.We find that tractography is a valuable tool in variable situations in modern neurosurgery. Our survey of recent reports demonstrates multiple potentially successful applications of white matter tractography in neurosurgery, with progress towards overcoming clinical challenges of standardization and interpretation.

show abstract

“…Thus, it is possible to hypothesize that a disruption of this pathway is responsible for the functional depression of those cerebral regions from where a motor or cognitive command originates, to reach the cerebellum which in turn redistributes new cerebellar-processed information back to the same cerebral regions. Since MCP and SCP are the feedback and feedforward limbs of the cerebello-cortical system it is reasonable to think that cerebellar white matter (WM) alterations, secondary to the presence of cerebellar damage, may affect the cerebello-cortical interaction and result in hypoactivity of supratentorial brain regions accounting for the various clinical dysfunctions typically observed [16–17]. It follows that investigating cerebellar white matter microstructure is required to understand the cerebello-cortical alterations subtending the complex cerebellar cognitive affective syndrome [3].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the ability of DTI tractography to map and quantify the whole trajectory of different cortico-cerebellar pathways has been demonstrated in normal adult brain [8, 21–22] as well as in patients with ataxia and cerebellar tremor [23]. A probabilistic atlas of cerebellar WM has been recently proposed contributing to a better understanding of cerebellar WM architecture [17]. One well-known limitation of DTI tractography is the inherent assumption of a single fiber direction per voxel, which limits its applicability to white matter areas of crossing-fibers.…”

Section: Introductionmentioning

confidence: 99%

Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging

et al. 2017

View full text Add to dashboard Cite

Over the last decades, the importance of cerebellar processing for cortical functions has been acknowledged and consensus was reached on the strict functional and structural cortico-cerebellar interrelations. From an anatomical point of view strictly contralateral interconnections link the cerebellum to the cerebral cortex mainly through the middle and superior cerebellar peduncle. Diffusion MRI (dMRI) based tractography has already been applied to address cortico-cerebellar-cortical loops in healthy subjects and to detect diffusivity alteration patterns in patients with neurodegenerative pathologies of the cerebellum. In the present study we used dMRI-based tractography to determine the degree and pattern of pathological changes of cerebellar white matter microstructure in patients with focal cerebellar lesions. Diffusion imaging and high-resolution volumes were obtained in patients with left cerebellar lesions and in normal controls. Middle cerebellar peduncles and superior cerebellar peduncles were reconstructed by multi fiber diffusion tractography. From each tract, measures of microscopic damage were assessed, and despite the presence of unilateral lesions, bilateral diffusivity differences in white matter tracts were found comparing patients with normal controls. Consistently, bilateral alterations were also evidenced in specific brain regions linked to the cerebellum and involved in higher-level functions. This could be in line with the evidence that in the presence of unilateral cerebellar lesions, different cognitive functions can be affected and they are not strictly linked to the side of the cerebellar lesion.

show abstract

A probabilistic atlas of the cerebellar white matter

Cited by 84 publications

References 41 publications

Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction

Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction

White matter tractography for neurosurgical planning: A topography-based review of the current state of the art

Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging

Contact Info

Product

Resources

About