A primary study of diffusion tensor imaging-based histogram analysis in vascular cognitive impairment with no dementia

Zhou, Yan; Qun-Xu,; Qin, Lu; Qian, Lijun; Cao, Wenlei; Xu, Jikai

doi:10.1016/j.clineuro.2010.09.007

Cited by 25 publications

(21 citation statements)

References 26 publications

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“…The histogram of each diffusion parameter presents the mean, the peak height and location, values that can be used to compare groups through statistical tests (Figure 1M). Histograms allow analysis of whole brain in an automated way, without any a priori specified ROI; however, such an approach requires the removal of the tissue of no interest (typically CSF), does not retain any information about the location of abnormalities and is sensitive to partial volume effect from atrophy (Della Nave et al, 2007; Jones and Cercignani, 2010; Zhou et al, 2011a). For such approach, tools such as TrackVis or MedINRIA can be used.…”

Section: Quantitative Analysismentioning

confidence: 99%

A hitchhiker's guide to diffusion tensor imaging

Soares¹,

Marques²,

Alves³

et al. 2013

Front. Neurosci.

681

549

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Diffusion Tensor Imaging (DTI) studies are increasingly popular among clinicians and researchers as they provide unique insights into brain network connectivity. However, in order to optimize the use of DTI, several technical and methodological aspects must be factored in. These include decisions on: acquisition protocol, artifact handling, data quality control, reconstruction algorithm, and visualization approaches, and quantitative analysis methodology. Furthermore, the researcher and/or clinician also needs to take into account and decide on the most suited software tool(s) for each stage of the DTI analysis pipeline. Herein, we provide a straightforward hitchhiker's guide, covering all of the workflow's major stages. Ultimately, this guide will help newcomers navigate the most critical roadblocks in the analysis and further encourage the use of DTI.

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Section: Quantitative Analysismentioning

confidence: 99%

A hitchhiker's guide to diffusion tensor imaging

Soares¹,

Marques²,

Alves³

et al. 2013

Front. Neurosci.

681

549

View full text Add to dashboard Cite

show abstract

“…26,27 None, however, have investigated the optic nerve directly in the presence of acute ON injury or inflammation. Therefore, the primary objective of the current study was to determine whether histogram analysis of FA (i.e., skewness) is better than mean FA at distinguishing ON eyes from fellow eyes and healthy control eyes at the time of the acute inflammatory event, as well as differentiate acute and chronic phases of ON in affected eyes.…”

mentioning

confidence: 99%

Skewness of Fractional Anisotropy Detects Decreased White Matter Integrity Resulting From Acute Optic Neuritis

Goodyear

Zayed

Cortese

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Citation: Goodyear BG, Zayed NMH, Cortese F, Trufyn J, Costello F. Skewness of fractional anisotropy detects decreased white matter integrity resulting from acute optic neuritis. Invest Ophthalmol Vis Sci. 2015;56:7597-7603. DOI:10.1167/ iovs.15-17335 PURPOSE. Diffusion tensor imaging (DTI) has demonstrated optic nerve damage associated with optic neuritis (ON); however, the usefulness of mean fractional anisotropy (FA) specifically is varied in the literature. We wished to determine whether histogram analysis of FA better detects ON damage than mean FA.METHODS. The ON patients (n ¼ 24) underwent DTI within 1 month of symptoms and then 6 months later (n ¼ 21). Twelve control subjects participated in one session. Mean FA and axial (AD), radial (RD), and mean (MD) diffusivities were compared between ON and fellow eyes, control eyes, and sessions. Values were sorted into bins, and coefficients of skewness of FA, AD, RD, and MD were compared between ON and fellow eyes, control eyes, and sessions.RESULTS. Mean AD, RD, and MD of ON eyes were significantly reduced compared with fellow eyes (P < 0.04) within 1 month of symptoms, but did not differ at 6 months. Mean AD and RD of ON eyes were significantly lower than control eyes (P < 0.05). No differences were observed for mean FA. The coefficient of skewness of FA was significantly different between ON eyes and fellow eyes (P ¼ 0.03) and control eyes (P ¼ 0.04) within 1 month of symptoms, but did not differ at 6 months. No differences were observed for AD, RD, and MD.CONCLUSIONS. Skewness of FA can detect white matter damage associated with ON and its recovery, which may further inform us of how DTI can measure white matter injury and repair.

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“…Previous DTI studies related to cognitive impairments in stroke have been mostly focused on small vessel disorders [7][8][9]. To the best of our knowledge there were no studies published aimed to delineate the correlation of the neuropsychological impairments and DTI metrics purely in moderate to large lesion in basal ganglia.…”

Section: Introductionmentioning

confidence: 92%

DTI Findings Correlated with Neurocognitive Impairments in Basal Ganglia Stroke: A Preliminary Study

Jun¹

2015

J Neurol Neurophysiol

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AbstractsObjective: Subcortical lesion involving basal ganglia can cause a wide range of behavioral and cognitive alterations largely attributed to disconnection of subcortical fibers; however, the underlying neural correlates of cognitive dysfunction based on the integrity of the white matter fiber has not yet been explored in stroke patients. Methods:The correlations among cognitive function and diffusion metrics of each subcortical fiber were investigated in nine basal ganglia stroke patients by diffusion tensor imaging (DTI) in our study. Results:Patient's general cognitive and verbal working memory function correlated well with the integrity of the left superior longitudinal fasciculus (SLF), nonverbal attention with the right inferior longitudinal fasciculus (ILF), SLF, and frontostriatal (FS) fibers. On the other hand, nonverbal long-term memory correlated well with the integrity of the right ILF and FS fibers. Conclusions:Neurocognitive characteristics of patients with basal ganglia stroke seem to reflect the integrity of subcortical fiber connectivity.

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A primary study of diffusion tensor imaging-based histogram analysis in vascular cognitive impairment with no dementia

Cited by 25 publications

References 26 publications

A hitchhiker's guide to diffusion tensor imaging

A hitchhiker's guide to diffusion tensor imaging

Skewness of Fractional Anisotropy Detects Decreased White Matter Integrity Resulting From Acute Optic Neuritis

DTI Findings Correlated with Neurocognitive Impairments in Basal Ganglia Stroke: A Preliminary Study

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