Skewness of Fractional Anisotropy Detects Decreased White Matter Integrity Resulting From Acute Optic Neuritis

Goodyear, Bradley G.; Zayed, Nourhan; Cortese, Filomeno; Trufyn, Jessie; Costello, Fiona

doi:10.1167/iovs.15-17335

Cited by 3 publications

(13 citation statements)

References 29 publications

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“…RD seems to have enhanced discriminatory value compared to FA for detecting the effects of ON within the visual system ( Figure 3B ). Within the optic nerve, a significant increase of RD was found for eleven out of sixteen performed comparisons, with five resulting from acute ON ( 27 , 28 , 103 , 104 ) and six from remote ON ( 25 , 26 , 103 , 109 ), though the ratio of significance was higher for acute ON. When assessing their ON patient group with a wide range of time from onset (median of 4.0 years since the first instance of ON), Naismith and colleagues [2010] ( 26 ) reported that they were able to distinguish the affected optic nerve from the unaffected optic nerve based on RD, while also differentiating between severity of visual outcomes (mild to severe).…”

Section: Resultsmentioning

confidence: 92%

“…For remote ON, RD within the optic nerve also correlates with RNFLT, contrast sensitivity, visual acuity, and the visually evoked potential latency and amplitude ( 25 , 26 , 109 ). Not all results showed a simple increase of RD within the optic nerve, with Goodyear and colleagues [2015] ( 28 ) finding that RD within the bilateral optic nerve decreased immediately after ON and increased back to a normal level after 6 months. Interestingly, Nguyen and colleagues [2022] ( 111 ) discovered a non-linear trend where RD within the affected optic nerve was less than the unaffected nerve at baseline, whilst it yielded higher RD values 3 months after ON onset, a relationship which still persisted 12 months after onset.…”

Section: Resultsmentioning

confidence: 99%

“…Unfortunately, most studies do not clearly or consistently classify their subjects into such groups. Our review has classified each reviewed study as either acute (onset within 1 month) or remote (time-since-onset typically greater than 1 year) in order to delineate the findings in a more effective manner based on the significant role that time from the onset has shown to have on the diffusivity measures ( 25 - 28 ).…”

Section: Introductionmentioning

confidence: 99%

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Diffusion tensor imaging of optic neuropathies: a narrative review

Cooper,

Tchernykh,

Shmuel

et al. 2024

Quant Imaging Med Surg

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Background and Objective Diffusion tensor imaging (DTI) has been implemented in a breadth of scientific investigations of optic neuropathies, though it has yet to be fully adopted for diagnosis or prognosis. This is potentially due to a lack of standardization and weak replication of results. The aim of this investigation was to review DTI results from studies specific to three distinct optic neuropathies in order to probe its current clinical utility. Methods We reviewed the DTI literature specific to primary open-angle glaucoma (POAG), optic neuritis (ON), and traumatic optic neuropathy (TON) by systematically searching the PubMed database on March 1 st , 2023. Four distinct DTI metrics are considered: fractional anisotropy (FA), along with mean diffusivity (MD, axial diffusivity (AD), and radial diffusivity (RD). Results from within-group, between-group, and correlational studies were thoroughly assessed. Key Content and Findings POAG studies most consistently report a decrease in FA, especially in the optic radiations, followed in prevalence by an increase in RD and then MD, whilst AD yields conflicting results between studies. It is notable that there is not an equal distribution of investigated DTI metrics, with FA utilized the most, followed by MD, RD, and AD. Studies of ON are similar in that the most consistent findings are specific to FA, RD, and MD. These results are specific to the optic nerve and radiation since only one study measured the intermediary regions. More studies are needed to assess the effect that ON has on the tracts of the visual system. Finally, only three studies assessing DTI of TON have been performed to date, displaying low to moderate replicability of results. To improve the level of agreement between studies assessing each optic neuropathy, an increased level of standardization is recommended. Conclusions Both POAG and ON studies have yielded some prevalent DTI findings, both for contrast and correlation-based assessments. Although the clinical need is high for TON, considering the limitations of the current diagnostic tools, too few studies exist to make confident conclusions. Future use of standardized and longitudinal DTI, along with the foreseen methodological and technical improvements, is warranted to effectively study optic neuropathies.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diffusion tensor imaging of optic neuropathies: a narrative review

Cooper,

Tchernykh,

Shmuel

et al. 2024

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

“…the fractional anisotropy value, the higher the anisotropy is. Fractional anisotropy can also indicate the injury and repair of white matter associated with ON, facilitating the detection of white matter [27]. DTI value is closely related to visual dysfunction of visual evoked potentials in patients with multiple sclerosis-ON [28].…”

Section: Tips Pertaining To Pathophysiological Informationmentioning

confidence: 99%

Recent advances in magnetic resonance imaging of optic neuritis

Zhang

Xian

2020

Chin J Acad Radiol

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Optic neuritis is a common cause of vision loss, but it is difficult to visualize the lesion well via conventional magnetic resonance imaging due to its small size and oblique orientations of the optic nerves. Some advanced techniques have been introduced into clinical practice in recent decades. Herein we review recent advances in magnetic resonance imaging techniques that are useful in cases of optic neuritis.

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“…For example, Yankeelov et al ( 2007 ) acquired dynamic contrast enhancement and ADC maps in a study of breast cancer, created ADC histograms and looked for statistically significant changes in individual bin frequency between pre- and post-treatment histograms. Goodyear et al ( 2015 ) studied changes in optic nerve mean MD, FA, axial (AD), and radial diffusivity (RD) as well as changes in histogram skewness of those quantities in optic neuritis patients. Wagner et al ( 2016 ) characterized pediatric cerebellar tumors using the 25th percentile, 75th percentile, and skewness of FA, MD, AD), and RD.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Diffusion Metric Map Similarity in Data From a Clinical Data Repository Using Histogram Distances

Warner

Helmer

2018

Front. Neurosci.

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As the sharing of data is mandated by funding agencies and journals, reuse of data has become more prevalent. It becomes imperative, therefore, to develop methods to characterize the similarity of data. While users can group data based on the acquisition parameters stored in the file headers, these gives no indication whether a file can be combined with other data without increasing the variance in the data set. Methods have been implemented that characterize the signal-to-noise ratio or identify signal drop-outs in the raw image files, but potential users of data often have access to calculated metric maps and these are more difficult to characterize and compare. Here we describe a histogram-distance-based method applied to diffusion metric maps of fractional anisotropy and mean diffusivity that were generated using data extracted from a repository of clinically-acquired MRI data. We describe the generation of the data set, the pitfalls specific to diffusion MRI data, and the results of the histogram distance analysis. We find that, in general, data from GE scanners are less similar than are data from Siemens scanners. We also find that the distribution of distance metric values is not Gaussian at any selection of the acquisition parameters considered here (field strength, number of gradient directions, b-value, and vendor).

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Skewness of Fractional Anisotropy Detects Decreased White Matter Integrity Resulting From Acute Optic Neuritis

Cited by 3 publications

References 29 publications

Diffusion tensor imaging of optic neuropathies: a narrative review

Diffusion tensor imaging of optic neuropathies: a narrative review

Recent advances in magnetic resonance imaging of optic neuritis

Characterization of Diffusion Metric Map Similarity in Data From a Clinical Data Repository Using Histogram Distances

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