A Primary Hepatic Plasma Cell Tumor in a Dog

Aoki, Mica; Kim, Tetsujun; Shimada, Terumasa; Kuwamura, Mitsuru; Yamate, Joji; Ohashi, Fumihito

doi:10.1292/jvms.66.445

Cited by 9 publications

(15 citation statements)

References 9 publications

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“…Single cases of extramedullary plasmacytoma have uncommonly been reported in the lung, larynx, spleen, kidney, liver, and uterus. 1,3,5,6 Primary (extramedullary) intracranial plasmacytoma is exceedingly rare in humans or animals, with only 2 cases reported in dogs. 8,9,10 Gross, histologic, immunohistochemical and ultrastructural features were described in 1 of the 2 reported canine intracerebral plasmacytomas.…”

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confidence: 99%

Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

et al. 2009

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A primary intracerebral plasmacytoma was identified in a 7-year-old spayed female Boston Terrier. Grossly, a well-demarcated, 2 cm in diameter, roughly spherical tumor was in the rostral aspect of the left cerebral hemisphere. Histologically, the neoplasm was composed of sheets of round cells with distinct plasmacytoid features and marked anisocytosis and anisokaryosis. Cells were positive for vimentin, CD18, CD79a, and lambda light-chain, and negative for kappa light chain, cytokeratin, lysozyme, glial fibrillary acidic protein, and S100 protein. Clonally rearranged B-cell antigen receptor genes were detected by PARR (polymerase chain reaction for antigen receptor rearrangements), confirming clonal proliferation of B lymphocytes. Although primary solitary intracerebral plasmacytoma is rare in dogs and other species, it should be included in the differential diagnosis for central nervous system round-cell neoplasms. Clonality testing can be utilized to support the histological diagnosis of this neoplasm type.

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confidence: 99%

Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

et al. 2009

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“…It is uncertain as to whether the long‐term survival observed in the present case was attributable to surgery plus adjuvant chemotherapy or due to marginal surgery and the non‐aggressive behaviour of the tumour, which has been seen in cutaneous EMP treated with incomplete excision 5 . Non‐cutaneous, non‐oral EMP has been associated with malignant behaviour in some cases, 7,8,16 and the sole hepatic PCT previously reported in a dog was associated with recurrence and tumour‐related death 11 . This suggests that adjuvant chemotherapy may have contributed to survival in the present case.…”

Section: Discussionmentioning

confidence: 73%

“…Localised cutaneous and oral EMPs are associated with an excellent prognosis when adequate local treatment is carried out, 4–6 whereas gastrointestinal non‐colorectal EMPs tend to have a more guarded prognosis 7–9 . Information on the behaviour of EMPs in other locations is scarce and consists of single case reports or small case series 11–17 . The present case report describes a novel case of multicentric PCT of the liver in a dog that experienced long‐term survival after treatment with surgery and adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 90%

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Long‐term survival of a dog diagnosed with a primary multicentric hepatic plasma cell tumour treated with surgery and chemotherapy

Pierini

Binanti²,

Marchetti

et al. 2021

Vet Record Case Reports

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A 7‐year‐old, intact, female Jack Russell terrier was presented for evaluation of a mammary nodule. Abdominal ultrasonography for initial staging revealed a 1 cm hypoechoic nodule within the left lateral hepatic lobe (LLHL), which was histologically determined to be a plasma cell tumour (PCT). Computed tomography revealed an additional 5 mm nodule in the right medial hepatic lobe (RMHL). Exploratory celiotomy showed that the PCT in the LLHL adhered to the gastric wall. Partial liver lobectomy and partial gastrectomy were carried out to remove the PCT in the LLHL. Marginal excision was done to remove the RMHL nodule, which was determined to be a PCT. The dog was treated with prednisone and melphalan for 6 months and remained in complete clinical remission for 37 months. Surgery and adjuvant chemotherapy were successful in maintaining long‐term remission in this patient. This is the first report of primary multicentric hepatic PCT in a dog.

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“…Multiple myeloma develops in bone marrow and is generally more malignant 7 . Extramedullary plasmacytomas often occur as a solitary mass and have been reported in the skin, mucocutaneous sites, third eyelid gland, larynx, trachea, and liver 8–13 . Cutaneous plasmacytomas are usually benign; while clinical signs and prognosis of the extramedullary plasmacytomas of soft tissues, except for skin, vary depending on the location of the tumor and metastasis 7 .…”

Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis-FDG-Pet/Ct of a Canine Splenic Plasma Cell Tumor

Lee¹,

Lee²,

Jung³

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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An 8-year-old Shih Tzu developed abdominal pain and hyperglobulinemia. A round splenic mass was noted radiographically and sonographically. The patient was evaluated by fluorodeoxyglucose positron emission tomography coupled with computed tomography (FDG-PET/CT). There was no evidence of metastasis or bone marrow involvement on PET/CT images. The standardized uptake value (SUV) of the splenic mass was increased over the reference range (SUV ¼ 4.83). The patient was diagnosed as splenic extramedullary plasmacytoma through immunohistopathologic study. After the splenectomy, the globulin level normalized and the patient is alive without complications. r

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A Primary Hepatic Plasma Cell Tumor in a Dog

Cited by 9 publications

References 9 publications

Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

Long‐term survival of a dog diagnosed with a primary multicentric hepatic plasma cell tumour treated with surgery and chemotherapy

Imaging Diagnosis-FDG-Pet/Ct of a Canine Splenic Plasma Cell Tumor

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