Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

Wettere, Arnaud J. Van; Linder, Keith E.; Suter, Steven E.; Olby, Natasha J.

doi:10.1354/vp.08-vp-0012-v-bc

Cited by 12 publications

(11 citation statements)

References 11 publications

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“…Because the diagnosis of primary CNS lymphoma ultimately depends on a rigorous postmortem examination to exclude underlying involvement of other organs, 2 the few case reports of primary CNS lymphoma in the veterinary literature are controversial. 3,17,32,37 It is hoped that this rigorous approach will lead to better designed prospective studies to confirm the hypothesis developed from this study that these histological patterns, together with their MRI profiles (Sturges et al, in preparation), accurately reflect targeting of specific anatomical compartments, which is in turn dependent on the expression of different homing molecules among the lymphoma subtypes. Such studies would lead to improved clinical diagnosis and prognosis, better understanding of the molecular pathogenesis, and innovative therapeutic targeting nervous system lymphoma.…”

Section: Discussionsupporting

confidence: 56%

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

et al. 2016

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Primary and secondary nervous system involvement occurs in 4% and 5%-12%, respectively, of all canine non-Hodgkin lymphomas. The recent new classification of canine malignant lymphomas, based on the human World Health Organization classification, has been endorsed with international acceptance. This histological and immunocytochemical classification provides a unique opportunity to study the histologic anatomic distribution patterns in the central and peripheral nervous system of these defined lymphoma subtypes. In this study, we studied a cohort of 37 dogs with lymphoma, which at necropsy had either primary (n = 1, 2.7%) or secondary (n = 36; 97.3%) neural involvement. These T- (n = 16; 43.2%) or B-cell (n = 21; 56.8%) lymphomas were further classified into 12 lymphoma subtypes, with predominant subtypes including peripheral T-cell lymphoma (PTCL) or diffuse large B-cell lymphoma (DLBCL), respectively. This systematic study identified 6 different anatomically based histologically defined patterns of lymphoma infiltration in the nervous system of dogs. Different and distinct combinations of anatomical patterns correlated with specific lymphoma subtypes. Lymphoma infiltration within the meningeal, perivascular, and periventricular compartments were characteristic of DLBCL, whereas peripheral nerve involvement was a frequent feature of PTCL. Similarly cell counts above 64 cells/μL in cerebrospinal samples correlated best with marked meningeal and periventricular lymphoma infiltration histologically. Prospective studies are needed in order to confirm the hypothesis that these combinations of histological neuroanatomic patterns reflect targeting of receptors specific for the lymphoma subtypes at these various sites.

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Section: Discussionsupporting

confidence: 56%

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

et al. 2016

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“…Positive CD79α labelling was observed in all evaluated canine and feline tumours, what was also confirmed in other research (Webb et al 2008, Van Wettere et al 2009). However, Moore et al revealed, that about 20% of EMPs are CD79α-negative (Moore et al 2000).…”

Section: Discussionsupporting

confidence: 89%

“…The predisposed locations in dogs are pinnae, digits, and oral cavity (Van Wettere et al 2009, Gupta et al 2014. In dogs, malignancy of the neoplasm depends on the primary lesion localization.…”

Section: Introductionmentioning

confidence: 99%

Morphology and immunoreactivity of canine and feline extramedullary plasmacytomas

Mikiewicz¹,

Otrocka-Domagała²,

Paździor-Czapula³

et al. 2016

Polish Journal of Veterinary Sciences

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The aim of the study was the evaluation of morphology and immunophenotype of canine (19 cases) and feline (7 cases) extramedullary plasmacytomas. Tumours, located in skin, oral cavity and spleen were surgically excised, fixed and processed for histopathology and immunohistochemistry (CD79α, CD18, proliferating cell nuclear antigen, metallothionein). Histologically, tumours were classified into mature, cleaved, asynchronous, polymorphous blastic, hyalin, or monomorphous blastic type. All evaluated tumours showed cytoplasmic expression of CD79α antigen. The expression of CD18 was observed in canine cutaneous and splenic tumours. In canine tumours expression of metallothionein was low to moderate, while in feline plasmacytomas -absent or low. In canine tumours, the mitotic index and proliferating cell nuclear antigen index were positively correlated with the expression of metallothionein. In feline tumours no correlation between mitotic index, proliferating cell nuclear antigen and metallothionein was found. This is the first study describing expression of metallothionein in canine and feline extramedullary plasmacytoma.

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“…However, extramedullary plasma cell tumors are extremely rare in the brain of humans (Ferrari et al 2012) and animals. Two cases of primary extramedullary plasma cell tumors in the brain have been reported in dogs (Sheppard et al 1997; Van Wettere et al 2009). To the author’s knowledge, no cases of primary extramedullary plasma cell tumor in the brain of rats or mice have been published.…”

Section: Maybe Not a No-brainermentioning

confidence: 99%

Proceedings of the 2016 National Toxicology Program Satellite Symposium

et al. 2016

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The 2016 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in San Diego, California, at the Society of Toxicologic Pathology’s (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) collaborations.

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Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

Cited by 12 publications

References 11 publications

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

Canine Nervous System Lymphoma Subtypes Display Characteristic Neuroanatomical Patterns

Morphology and immunoreactivity of canine and feline extramedullary plasmacytomas

Proceedings of the 2016 National Toxicology Program Satellite Symposium

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