A presumed case of new-onset focal seizures as a delayed complication of COVID-19 infection

Park, Sihyeong; Majoka, Haroon; Sheikh, Ajaz; Ali, Imran

doi:10.1016/j.ebr.2021.100447

Cited by 9 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCNS includes complications ranging from acute course diseases such as stroke to a rare and long course disease such as Guillain–Barre syndrome for up to six months post-COVID diagnosis [ 16 , 18 ]. Not limited to the epidemiological trends of common symptoms, recent case studies have also reported the occurrence of new-onset focal or generalized seizures [ 19 ], refractory status epilepticus [ 20 ], hearing loss, and vestibule-cochlear neuritis [ 21 , 22 ]. There are also reports of spinal cord disease, such as longitudinally extensive transverse myelitis (LETM) [ 23 ].…”

Section: Impact Of Neurological and Psychological Healthmentioning

confidence: 99%

“…Concerning the neurological complications, virus neurotropism and subsequent neuroinflammation leading to pathophysiological impacts on the cortex, limbic system, and brain stem and hypothalamic–pituitary–adrenal axis would explain most of the observed symptoms [ 10 , 19 , 21 – 24 , 85 – 87 ]. Although there are limited case reports of fully diagnosed dysfunctional Limbic system, it is hypothesized that several clinical symptoms such as emotional and cognitive disturbances, anxiety, depression, uncoordinated movements, partial seizures, and myoclonus can be partly explained in the post-COVID context [ 30 , 30 , 33 ].…”

Section: Putative Patho-physiological Mechanisms Involved In Long-covidmentioning

confidence: 99%

See 1 more Smart Citation

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Umesh

Pranay

Pandey³

et al. 2022

Infection

View full text Add to dashboard Cite

Purpose Apart from the global disease burden of acute COVID-19 disease, the health complications arising after recovery have been recognized as a long-COVID or post-COVID-19 syndrome. Evidences of long-COVID symptoms involving various organ systems are rapidly growing in literature. The objective was to perform a rapid review and evidence mapping of systemic complications and symptoms of long-COVID and underlying pathophysiological mechanisms. Methods Publications reporting clinical trials, observational cohort studies, case–control studies, case-series, meta-analysis, and systematic reviews, focusing on the squeal of the disease, consequences of COVID-19 treatment/hospitalization, long-COVID, chronic COVID syndrome, and post acute COVID-19 were reviewed in detail for the narrative synthesis of frequency, duration, risk factors, and pathophysiology. Results The review highlights that pulmonary, neuro-psychological, and cardiovascular complications are major findings in most epidemiological studies. However, dysfunctional gastrointestinal, endocrine, and metabolic health are recent findings for which underlying pathophysiological mechanisms are poorly understood. Analysis of the clinical trial landscape suggests that more than 50% of the industry-sponsored trials are focused on pulmonary symptoms. In contrast to the epidemiological trends and academic trials, cardiovascular complications are not a focus of industry-sponsored trials, suggestive of the gaps in the research efforts. Conclusion The gap in epidemiological trends and academic trials, particularly concerning cardiovascular complications not being a focus of industry-sponsored trials is suggestive of the gaps in research efforts and longer follow-up durations would help identify other long-COVID-related health issues such as reproductive health and fertility. Supplementary Information The online version contains supplementary material available at 10.1007/s15010-022-01835-6.

show abstract

Section: Impact Of Neurological and Psychological Healthmentioning

confidence: 99%

Section: Putative Patho-physiological Mechanisms Involved In Long-covidmentioning

confidence: 99%

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Umesh

Pranay

Pandey³

et al. 2022

Infection

View full text Add to dashboard Cite

show abstract

“…Overall, seizures appear to be a rare occurrence following COVID-19 infection [ 11 ]. At the same time, there is a limited but growing body of evidence that suggests that new-onset focal seizures and epilepsy should be considered a delayed central nervous system manifestation of COVID-19 infection [ 12 ]. Carroll et al reported refractory status epilepticus in a 69-year-old African American woman six weeks after COVID-19 infection [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Following a hospital admission, their patient was well enough to be discharged. A second case report details focal seizures in a 45-year-old patient, which, at the time of publication of the report, were still occurring and required ongoing medication [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Focal Seizures in a Child Following COVID-19 Infection: A Case Report

Mydam¹,

Midivelly²,

Chennakesavulu³

et al. 2022

Cureus

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) has been shown to impact multiple organs, even in instances where patients did not show any symptoms. In this case report, we detail a six-year-old male child presenting with focal seizures without an antecedent history of epilepsy. The child presented with twitching movements on the right side of the face involving the oral cavity. Non-contrast brain MRI showed meningoencephalitis. He was given antibiotics, antipyretics, and antiepileptic drugs (AEDs), but his clinical condition continued to deteriorate despite treatment. Oropharyngeal and nasopharyngeal swabs tested positive for COVID-19. Thus, treatment was initiated for COVID-19 encephalitis and seizures with intravenous immune globulin (IVIG) and steroids. Frequency of seizures decreased dramatically after steroids were initiated and remained infrequent during the five days of steroid therapy. After steroids were discontinued seizures returned but were shorter, less frequent and manageable with AEDs. The child was discharged on AEDs and was seizure-free at six months of follow-up. The following case report details the disease and treatment pathway of the patient.

show abstract

“…5 additional citations were identified after hand-searching the reference list of the included studies; therefore, our review ultimately encompasses the findings of 92 full-text citations. Specifically, these includes 60 prospective studies, 18 case reports, [63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] 12 retrospective studies, [81][82][83][84][85][86][87][88][89][90][91][92] and 2 bidirectional studies. 93,94 There were no randomized controlled trials identified.…”

Section: Summary Of Study Characteristcsmentioning

confidence: 99%

Post-Acute COVID-19 Syndrome for Anesthesiologists: A Narrative Review and a Pragmatic Approach to Clinical Care

Kopanczyk

Kumar

Papadimos

2022

Journal of Cardiothoracic and Vascular Anesthesia

View full text Add to dashboard Cite

Post-acute coronavirus disease 2019 (COVID-19) syndrome is a novel, poorly understood clinical entity with life-impacting ramifications. Patients with this syndrome, also known as “ COVID-19 long-haulers ,” often present with non-specific ailments involving more than one body system. The most common complaints include dyspnea, fatigue, brain fog, and chest pain. There is currently no single agreed-upon definition for post-acute COVID-19 syndrome, but most agree that criterion for this syndrome is the persistence of mental and physical health consequences after initial infection. Given the millions of acute infections in the U.S. over the course of the pandemic, perioperative providers will encounter these patients in clinical practice in growing numbers. Symptoms of the COVID-19 long-haulers should not be minimized as these patients are at higher risk for postoperative respiratory complications and perioperative mortality for up to 7 weeks after initial illness. Instead, a cautious multidisciplinary preoperative evaluation should be performed. Perioperative care should be viewed through the prism of best practices already in use such as avoidance of benzodiazepines in patients with cognitive impairment and use of lung protective ventilation. Recommendations especially relevant to the COVID-19 long-haulers include assessment of critical care myopathies and neuropathies to determine suitable neuromuscular blocking agents and reversal, preoperative workup of insidious cardiac or pulmonary pathologies in previously healthy patients, and thorough medication review, particularly of anticoagulation regimens and chronic steroid use. In this article, we define the syndrome, synthesize the available scientific evidence, and make pragmatic suggestions regarding the perioperative clinical care of COVID-19 long-haulers.

show abstract

A presumed case of new-onset focal seizures as a delayed complication of COVID-19 infection

Cited by 9 publications

References 20 publications

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Evidence mapping and review of long-COVID and its underlying pathophysiological mechanism

Focal Seizures in a Child Following COVID-19 Infection: A Case Report

Post-Acute COVID-19 Syndrome for Anesthesiologists: A Narrative Review and a Pragmatic Approach to Clinical Care

Contact Info

Product

Resources

About