A prenylated xanthone from Allanblackia floribunda

Nkengfack, Augustin E.; Azebaze, Guy A.; Vardamides, Juliette Cathérine; Fomum, Zacharias Tanee; Heerden, Fanie R. van

doi:10.1016/s0031-9422(02)00036-5

Cited by 49 publications

(40 citation statements)

References 8 publications

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“…Bioguided investigation of these extracts resulted in the isolation and characterization of four benzophenones, guttiferone A (1) [3], garcinol (2), cambogin (3) [2] and guttiferone F (4) [4], along with three xanthones, allanxanthone A (5) [5], xanthone V 1 (6) and globulixanthone C (7) [6] (Figure 1). Compounds (1) and (6) were isolated from S. globulifera leaves, as compounds (2-5) were obtained from A. monticola fruits.…”

Section: Resultsmentioning

confidence: 99%

“…Clusiaceae are well known to biosynthesize bioactive benzophenones and xanthones [2][3][4][5][6][7][8]. Xanthones are known to show a wide range of biological activity such as antibacterial, antidiabetic, antiplasmodial, human cancer cell line growth inhibition, antihypertensive and vasorelaxing, cardiovascular protection, inhibition of HIV-1 reverse transcriptase and HIV-1 replication [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Leishmanicidal and Cholinesterase Inhibiting Activities of Phenolic Compounds from Allanblackia monticola and Symphonia globulifera

et al. 2007

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Abstract:In a preliminary antiprotozoal screening of several Clusiaceae species, the methanolic extracts of Allanblackia monticola and Symphonia globulifera showed high in vitro leishmanicidal activity. Further bioguided phytochemical investigation led to the Molecules 2007, 12 1549 isolation of four benzophenones: guttiferone A (1), garcinol (2), cambogin (3) and guttiferone F (4), along with three xanthones: allanxanthone A (5), xanthone V 1 (6) and globulixanthone C (7) as active constituents. Compounds 1 and 6 were isolated from S. globulifera leaves, while compounds 2-5 were obtained from A. monticola fruits. Guttiferone A (1) and F (4) showed particulary strong leishmanicidal activity in vitro, with IC 50 values (0.2 µM and 0.16 µM, respectively) comparable to that of the reference compound, miltefosine (0.46 µM). Although the leishmanicidal activity is promising, the cytotoxicity profile of these compounds prevent at this state further in vivo biological evaluation. In addition, all the isolated compounds were tested in vitro for their anticholinesterase properties. The four benzophenones showed potent anticholinesterase properties towards acetylcholinesterase (AChE) and butylcholinesterase (AChE). For AChE, the IC 50 value (0.66 µM) of garcinol (2) was almost equal to that of the reference compound galanthamine (0.50 µM). Furthermore, guttiferone A (1) and guttiferone F (4) (IC 50 = 2.77 and 3.50 µM, respectively) were more active than galanthamine (IC 50 = 8.5) against BChE.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leishmanicidal and Cholinesterase Inhibiting Activities of Phenolic Compounds from Allanblackia monticola and Symphonia globulifera

et al. 2007

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“…Rutoside found in the extract is reported to improve levels of plasma free radicals (Cesarone et al, 2002) and to exert a cardioprotective effect (Van Acker et al, 1993). Furthermore, Nkengfack et al (2002) isolated many xanthones from Allanblackia floribunda. Xanthones and xanthone derivatives have been shown to have beneficial effects on some cardiovascular diseases, including ischemic heart disease, atherosclerosis, hypertension and thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. (Clusiaceae) aqueous extract in alcohol- and sucrose-induced hypertensive rats

Bilanda¹,

Dimo²,

Djomeni³

et al. 2010

Journal of Ethnopharmacology

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“…Oleic and stearic acids are reported to lower plasma cholesterol levels (Bonanome and Grundy, 1988). Also, the fat from Allanblackia seeds has a relatively high melting point (35 o C), which makes it more valuable than other fats because it can be used without the need to transform its consistency for margarines and similar products (Nkengfack et al, 2002). These characteristics make Allanblackia seeds extremely valuable to food and cosmetic industries.…”

Section: Introductionmentioning

confidence: 99%

Germination of Allanblackia floribunda Seeds: The Effect of Soak Duration in Fluridone on Germination and Seedling Growth

Ileleji¹

2015

AFF

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Abstract:Allanblackia seeds contain about 72% white fat (mostly of oleic and stearic acid), with high medicinal and industrial value, but the plant has not been domesticated, so seeds are only gotten from the wild. The demand for seeds of the wild Allanblackia floribunda exceeds supply and efforts to domesticate the plant to increase seed availability have been unsuccessful due to long seed dormancy periods. Soaking scarified seeds from immature fruits in water or fluridone shortened dormancy to less than 3 months, but the effects of different soak durations on germination, dormancy and seedling vigor, are not fully understood. This study aimed to determine the effects of three soak durations (1, 6, and 12 h) in water or fluridone (10 µM or 30 µM) on seed germination and seedling growth. The study was a 3 x 3 factorial experiment arranged in a Completely Randomized Design, using scarified immature seeds. At 16 weeks after treatment, seedlings were transplanted into polypots filled with topsoil and assessed weekly for the effects of treatments on seedling growth (leaf number and plant height). The % germination increased as the duration of soak in water or 10 µM fluridone increased from 1 to 12 h. The tendency to obtain 75-100% germination was higher when seeds were soaked in 10 µM fluridone (i.e., for 6 or 12 h) as compared to soaking in water for up to 12 h. The shortest duration (72 d, i.e., approx. 2.5 months) to achieve >75% germination was when Allanblackia seeds were soaked for 6 h in 10 µM fluridone. Soaking the seeds for 12 h in 10 µM fluridone resulted in 100% germination in 3 months. At transplanting, seedlings from fluridone treated seeds were taller, and had more leaves than those from seeds soaked in water for 1 or 6 h, but the reverse was observed in seedlings from seeds soaked for 12 h in water. However, these effects diminished after 2 weeks, when the seedlings have become established. This study has shown a promising method for achieving rapid and efficient germination of Allanblackia seeds with no noticeable adverse effects on seedling establishment.

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A prenylated xanthone from Allanblackia floribunda

Cited by 49 publications

References 8 publications

Leishmanicidal and Cholinesterase Inhibiting Activities of Phenolic Compounds from Allanblackia monticola and Symphonia globulifera

Leishmanicidal and Cholinesterase Inhibiting Activities of Phenolic Compounds from Allanblackia monticola and Symphonia globulifera

Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. (Clusiaceae) aqueous extract in alcohol- and sucrose-induced hypertensive rats

Germination of Allanblackia floribunda Seeds: The Effect of Soak Duration in Fluridone on Germination and Seedling Growth

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