A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice

Zazara, Dimitra E.; Wegmann, Michael; Giannou, Anastasios D.; Hierweger, Alexandra Maximiliane; Alawi, Malik; Thiele, Kristin; Huber, Samuel; Pincus, Maike; Muntau, Ania C.; Solano, María Emilia; Arck, Petra C.

doi:10.1016/j.jaci.2020.01.050

Cited by 16 publications

(6 citation statements)

References 109 publications

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“…Oestrogen has been implicated in sex-related differences in the development and clinical outcomes of asthma, although the published data are conflicting [75]. In a recent study, asthma susceptibility and severity in the offspring increases in a sex-specific manner during prenatal stress challenges, with the disruption of the airway epithelium and consequent increased permeability orchestrating the foetal origin of asthma [76].…”

Section: Sex Hormones and Lungsmentioning

confidence: 99%

Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Brandi

Giustina

2020

Trends in Endocrinology & Metabolism

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The recent Coronavirus-19 pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age dependent disease susceptibility and mortality in the elderly suggest to sex hormones as main actors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of Coronavirus-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management of men and women affected by the disease.

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Section: Sex Hormones and Lungsmentioning

confidence: 99%

Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Brandi

Giustina

2020

Trends in Endocrinology & Metabolism

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“…However, this may also lead to existing airway inflammation and dysfunction in asthma by amplifying pre-existing allergic inflammation. 5 Experiments by Zazara 10 and Song 11 confirmed the association of epithelial cells to asthma. Reducing the incidence and extent of asthma through upregulation of epithelial cell apoptosis would be a therapeutic direction for asthma.…”

Section: Respiratory Epithelial Cellsmentioning

confidence: 90%

“…Enhanced airway hyperresponsiveness, inflammation and fibrosis in offspring mice were found to be present only in female BMC mice with prenatal stress-exposed lungs. 10 Song found reduced expression of SIRT3 in the bronchial tissue https://doi.org/10.2147/JAA.S395490…”

Section: Chemokines and Inflammatory Cells And Asthmamentioning

confidence: 98%

Role of Chemokines and Inflammatory Cells in Respiratory Allergy

Bao¹,

Zhu²

2022

JAA

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The idea of "one airway, one disease" has been gaining importance in the last decade. In the upper and lower airways, allergic mechanisms interact with each other. In the initial stage of respiratory allergic inflammation, allergens contact the respiratory epithelium, which produces chemokines and inflammatory factors, which cause allergic reactions by binding to the corresponding receptors and chemotactic various inflammatory cells to reach the epithelium and tissues. It also drives inflammatory cells to activate and produce more inflammatory factors, thus producing a cascade amplification effect. Inflammatory cell aggregation and activation are very complex and interact with each other in a lattice structure. By blocking the action of various chemokines, inflammatory cell aggregation is reduced, and ultimately the symptoms of respiratory allergy are alleviated. Chemokines can serve as cues for coordinated recruitment of immune cells into and out of tissues, as well as directing the spatial organization of immune cells within tissues and cellular interactions. Chemokines are critical in directing immune cell migration and thus have an important role in the direction of respiratory allergy: however, chemokines are also involved in the production and recruitment of immune cells that contribute to respiratory allergy. In this article, linking the upper and lower respiratory tracts. We review the role of the chemokine system in the respiratory immune response and discuss how respiratory disease modulates overall chemokines to shape the type and outcome of the immune response to the treatment of respiratory allergic disease so that we can further deepen our knowledge of chemokines in the direction of respiratory allergy. In the future, we can do drug research and development based on this network structure and explore new research directions.

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“…In a cohort of 49 children with wheezing and airway hyper-responsiveness, it was indicated that remodeling was independent from inflammation [10]. Furthermore, it was suggested in a mouse model that the disruption of the airway epithelium during embryogenesis is a key event that imprints the lungs to develop asthma and airway wall remodeling later in life [42].…”

Section: The Maturation Of the Epithelium And The Basement Membrane I...mentioning

confidence: 99%

Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology

Fang

Roth

2021

JPM

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Airway wall remodeling is a pathology occurring in chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and fibrosis. In 2017, the American Thoracic Society released a research statement highlighting the gaps in knowledge and understanding of airway wall remodeling. The four major challenges addressed in this statement were: (i) the lack of consensus to define “airway wall remodeling” in different diseases, (ii) methodologic limitations and inappropriate models, (iii) the lack of anti-remodeling therapies, and (iv) the difficulty to define endpoints and outcomes in relevant studies. This review focuses on the importance of cell-cell interaction, especially the bronchial epithelium, in asthma-associated airway wall remodeling. The pathology of “airway wall remodeling” summarizes all structural changes of the airway wall without differentiating between different pheno- or endo-types of asthma. Indicators of airway wall remodeling have been reported in childhood asthma in the absence of any sign of inflammation; thus, the initiation event remains unknown. Recent studies have implied that the interaction between the epithelium with immune cells and sub-epithelial mesenchymal cells is modified in asthma by a yet unknown epigenetic mechanism during early childhood.

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A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice

Cited by 16 publications

References 109 publications

Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Role of Chemokines and Inflammatory Cells in Respiratory Allergy

Airway Wall Remodeling in Childhood Asthma—A Personalized Perspective from Cell Type-Specific Biology

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