A Preliminary Study on the Effects of Acellular Tissue Graft Augmentation in Acute Achilles Tendon Ruptures

Lee, Daniel K.

doi:10.1053/j.jfas.2007.08.015

Cited by 83 publications

(75 citation statements)

References 17 publications

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“…For these reasons, the use of xenografts took off, with numerous products currently available [307,308]. Although positive functional scores and improved movement as early as 6 months post-operation have been reported [309], many studies have demonstrated high failure rates and tearing incidents [310][311][312][313], which may be attributed to processing conditions (e.g. decellularisation, cross-linking, sterilisation) employed to battle immune rejection, which remains the major obstacle for both allogeneic [314,315] and xenogeneic [316] approaches.…”

Section: Tissue Grafts -The Top-down Approach For Tendon Repairmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

179

188

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Section: Tissue Grafts -The Top-down Approach For Tendon Repairmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

179

188

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“…These aforementioned scaffolds are examples of extracellular matrix grafts. Acellular dermal human and porcine grafts have been reported to cause foreign body giant cell reactions [8][9][10][11][12][13][14][15][16][17][18]. Synthetic grafts, such as Poly-L-lactic acid (PLLA), polyactide-co-glycolic acid (PLGA), and polyglycolic acid (PGA), have also been found to evoke local foreign body giant cell reactions [1].…”

Section: Discussionmentioning

confidence: 99%

Foreign Body Inflammatory Response following Rotator Cuff Repair with Biologic Scaffold Augmentation

Hill¹,

Fashandi²,

Diduch³

2018

Surg Rehabil

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Arthroscopic rotator cuff repair with scaffold augmentation is used to produce a solid construct and decrease the probability of suture pull out. This is achieved biomechanically through redistributing the forces on the healing tendon and unloading forces onto the scaffold. Scaffolds provide a biomechanical advantage in outcomes of rotator cuff repairs by decreasing repair failures. This therapeutic advantage may be diminished or voided by a patient's immunologic response to the scaffold. This case report highlights how absorbable polymers in scaffolds can cause a foreign body inflammatory response, which can result in symptoms of pain and swelling of the affected joint. If a foreign body inflammatory response is suspected in a patient, arthroscopic debridement and scaffold removal should be performed. Symptoms will likely resolve and not reoccur.

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“…AT rupture is commonly seen in middle age athletes, usually after sudden push off on the weight bearing foot 3 . Different materials and techniques have been investigated for AT repair; some studies reported the use of synthetic patches for tendon reinforcement [4][5][6] . We discuss the long-term viability of a patient who had undergone synthetic augmentation to a sutured AT after four days.…”

Section: Introductionmentioning

confidence: 99%

Failed synthetic graft after acute Achilles tendon repair

Mohamed

Oliva

Nardoni

et al. 2017

MLTJ

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SummaryBackground: The present case report aimed to determine the results of Flexor Hallucis Longus (FHL) transfer as a second surgery after synthetic tissue reinforcement graft (Artelon ® ) implanted to a primary repaired Achilles tendon (AT), that was undertaken by another orthopedic. One year postoperative the patient was referred to us with retrocalcaneal pain and difficulty in walking, associated with stiffness and significant impairment of daily living activities. Methods: MRI and full clinical examination were the outcome measures applied before and 1 year after surgery. Removal of the synthetic graft and subsequent FHL autologous transfer was undertaken and the graft was sent for histology examination. After removing the below knee leg cast, patient started rehabilitation program supervised by a trained physiotherapist. Results: The patient was allowed to return to his normal activities at the sixth postoperative month, 1 year post-surgery MRI showed correct position of the autograft in the calcaneous bone and in the centre of the native AT plus reduced oedema of the AT body, with clinical improvement of the patient who reported no pain and was able to walk on tiptoes. Conclusion: Synthetic patch augmentation to enhance tendon healing should be subjected to proper investigation before using it in routine parctice, as it may act as a barrier against proper tendon healing. Level of evidence: V.

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A Preliminary Study on the Effects of Acellular Tissue Graft Augmentation in Acute Achilles Tendon Ruptures

Cited by 83 publications

References 17 publications

The past, present and future in scaffold-based tendon treatments

The past, present and future in scaffold-based tendon treatments

Foreign Body Inflammatory Response following Rotator Cuff Repair with Biologic Scaffold Augmentation

Failed synthetic graft after acute Achilles tendon repair

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