A preliminary study on pro- and anti-inflammatory cytokine profiles in Plasmodium vivax malaria patients from central zone of India

Jain, Vidhan; Singh, Puspendra P.; Silawat, N.; Patel, Rakesh; Saxena, Ajay K.; Bharti, Praveen K.; Shukla, Man Mohan; Biswas, Subrata; Singh, Neeru

doi:10.1016/j.actatropica.2009.11.009

Cited by 30 publications

(25 citation statements)

References 36 publications

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“…It has been shown that P. vivax patients presenting with moderate to severe anemia exhibited higher concentrations of monocyte chemoattractant protein-1 (MCP-1) (17) It was shown that patients with mild anemia associated with vivax malaria presented higher levels of gamma interferon (IFN-␥) and interleukin-10 (IL-10) (93), as well as tumor necrosis factor (TNF) (61), than the nonanemic ones. IFN-␥, TNF, and IL-10 are some mediators released as a result of T cell activation (82).…”

Section: Dyserythropoiesis and Immune-mediated Anemiamentioning

confidence: 99%

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

et al. 2014

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The pathogenesis of malaria is complex, generating a broad spectrum of clinical manifestations. One of the major complications and concerns in malaria is anemia, which is responsible for considerable morbidity in the developing world, especially in children and pregnant women. Despite its enormous health importance, the immunological mechanisms involved in malaria-induced anemia remain incompletely understood. Plasmodium vivax, one of the causative agents of human malaria, is known to induce a strong inflammatory response with a robust production of immune effectors, including cytokines and antibodies. Therefore, it is possible that the extent of the immune response not only may facilitate the parasite killing but also may provoke severe illness, including anemia. In this review, we consider potential immune effectors and their possible involvement in generating this clinical outcome during P. vivax infections.

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Section: Dyserythropoiesis and Immune-mediated Anemiamentioning

confidence: 99%

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

et al. 2014

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“…Regarding the cell-mediated response, ILs released by T lymphocytes increase the phagocytic activity of macrophages, neutrophils, dendritic cells, monocytes and NK lymphocytes to combat infections [40,[42][43][44].…”

Section: Genetic Variability Of Il-2 and The Physiopathogenesis Of Pamentioning

confidence: 99%

Human Interleukin 2 (IL-2) Promotion of Immune Regulation and ClinicalOutcomes: A Review

Capobianco¹,

Cassiano²,

Furini³

et al. 2016

J Cytokine Biol

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Interleukin 2 (IL-2) is a monomeric glycoprotein that is primarily produced by activated CD4+ T cells, CD8+ T cells and dendritic cells. It is characterized as a proinflammatory cytokine that is secreted by Th1 cells. IL-2 plays a central role in the activation of regulatory T cells to produce the cytokines tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). IL-2 may also enhance the cytolytic activity of natural killer cells, thereby ensuring their significance in the control of the immune response, and effectively participate in the pathogenesis of several pathological conditions, such as cancer and metabolic, infectious, autoimmune and inflammatory diseases. We emphasize the importance of studies of IL-2 and discuss perspectives resulting from our increasing understanding of genetic diversity and its role in the immune response.

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“…Cell-mediated immunity, with surrogate markers including pro-inflammatory cytokines, has been shown to play a role in controlling malaria parasitemia 11,12 and symptom severity, [13][14][15][16] and to likely impact transmission. [17][18][19] Interferon-gamma (IFN-γ), produced by Th1 and natural killer cells, is involved in activation of macrophage and iNOS and is an important signal in fighting intracellular infections.…”

Section: Introductionmentioning

confidence: 99%

Human Host-Derived Cytokines Associated with Plasmodium vivax Transmission from Acute Malaria Patients to Anopheles darlingi Mosquitoes in the Peruvian Amazon

Abeles¹,

Chuquiyauri²,

Tong³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Infection of mosquitoes by humans is not always successful in the setting of patent gametocytemia. This study tested the hypothesis that pro-or anti-inflammatory cytokines are associated with transmission of Plasmodium vivax to Anopheles darlingi mosquitoes in experimental infection. Blood from adults with acute, non-severe P. vivax malaria was fed to laboratory-reared F1 An. darlingi mosquitoes. A panel of cytokines at the time of mosquito infection was assessed in patient sera and levels compared among subjects who did and did not infect mosquitoes. Overall, blood from 43 of 99 (43%) subjects led to mosquito infection as shown by oocyst counts. Levels of IL-10, IL-6, TNF-α, and IFN-γ were significantly elevated in vivax infection and normalized 3 weeks later. The anti-inflammatory cytokine IL-10 was significantly higher in nontransmitters compared with top transmitters but was not in TNF-α and IFN-γ. The IL-10 elevation during acute malaria was associated with P. vivax transmission blocking.

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A preliminary study on pro- and anti-inflammatory cytokine profiles in Plasmodium vivax malaria patients from central zone of India

Cited by 30 publications

References 36 publications

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question

Human Interleukin 2 (IL-2) Promotion of Immune Regulation and ClinicalOutcomes: A Review

Human Host-Derived Cytokines Associated with Plasmodium vivax Transmission from Acute Malaria Patients to Anopheles darlingi Mosquitoes in the Peruvian Amazon

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