A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants

Rosin, Samuel; Xia, Kai; Azcárate-Peril, M. Andrea; Carlson, Alexander L.; Propper, Cathi B.; Thompson, Amanda L.; Grewen, Karen; Knickmeyer, Rebecca

doi:10.1016/j.psyneuen.2020.105046

Cited by 28 publications

(19 citation statements)

References 50 publications

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“…Studies from GF rodents indicate that lack of gut microbiota is associated with a hyperreactive HPA axis in response to stress. This effect can be partially normalized by colonizing fecal matter with the normal flora of healthy rodents, indicating the importance of microbiota in maintaining homeostasis in the HPA axis [ 81 ]. Similarly, intestinal microbes have been shown to normalize the stress response by affecting HPA axis gene expression in conditions of chronic stress.…”

Section: Microbiota-gut-brain Axismentioning

confidence: 99%

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

et al. 2022

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Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally in vital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protection against the development of neurological diseases. Emerging evidence shows that gut microbiota have significant roles in maintaining adequate concentrations of dopamine via intricate, bidirectional communication known as the microbiota-gut-brain axis. The vagus nerve, immune system, hypothalamus–pituitary–adrenal axis, and microbial metabolites serve as important mediators of the reciprocal microbiota-gut-brain signaling. Furthermore, gut microbiota contain intrinsic enzymatic activity that is highly involved in dopamine metabolism, facilitating dopamine synthesis as well as its metabolite breakdown. This review examines the relationship between key genera of gut microbiota such as Prevotella, Bacteroides, Lactobacillus, Bifidobacterium, Clostridium, Enterococcus, and Ruminococcus and their effects on dopamine. The effects of gut dysbiosis on dopamine bioavailability and the subsequent impact on dopamine-related pathological conditions such as Parkinson’s disease are also discussed. Understanding the role of gut microbiota in modulating dopamine activity and bioavailability both in the periphery and in the central nervous system can help identify new therapeutic targets as well as optimize available methods to prevent, delay, or restore dopaminergic deficits in neurologic and metabolic disorders.

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Section: Microbiota-gut-brain Axismentioning

confidence: 99%

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

et al. 2022

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“…IL-6 and IL-1β [ 100 ]. Likewise, the supplementation of beneficial gut microbes has been found to normalize the stress response and maintain homeostasis of the HPA axis [ 101 ]. Therefore, introduction of favorable gut microbes via MD diet adherence can restore HPA axis integrity and promote favorable effects on morphine re-instatement.…”

Section: Dietary Intervention Gut Microbiota Dopamine and Pdmentioning

confidence: 99%

Impact of Nutrition, Microbiota Transplant and Weight Loss Surgery on Dopaminergic Alterations in Parkinson’s Disease and Obesity

Hamamah

Hajnal

Covașă

2022

IJMS

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Parkinson’s disease (PD), the second most common neurodegenerative disorder worldwide, is characterized by dopaminergic neuron degeneration and α-synuclein aggregation in the substantia nigra pars compacta of the midbrain. Emerging evidence has shown that dietary intake affects the microbial composition in the gut, which in turn contributes to, or protects against, the degeneration of dopaminergic neurons in affected regions of the brain. More specifically, the Mediterranean diet and Western diet, composed of varying amounts of proteins, carbohydrates, and fats, exert contrasting effects on PD pathophysiology via alterations in the gut microbiota and dopamine levels. Interestingly, the negative changes in the gut microbiota of patients with PD parallel changes that are seen in individuals that consume a Western diet, and are opposite to those that adhere to a Mediterranean diet. In this review, we first examine the role of prominent food groups on dopamine bioavailability, how they modulate the composition and function of the gut microbiota and the subsequent effects on PD and obesity pathophysiology. We then highlight evidence on how microbiota transplant and weight loss surgery can be used as therapeutic tools to restore dopaminergic deficits through optimizing gut microbial composition. In the process, we revisit dietary metabolites and their role in therapeutic approaches involving dopaminergic pathways. Overall, understanding the role of nutrition on dopamine bioavailability and gut microbiota in dopamine-related pathologies such as PD will help develop more precise therapeutic targets to rescue dopaminergic deficits in neurologic and metabolic disorders.

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“…Many studies have suggested that there is a strong link between changes in the gut microbiota composition and the outbreak of psychological outcomes such as anxiety-like symptoms and depression already at a young age [56] . Experimental results in mice suggest that a dysbiosis of the gut microbiota could turn into psychological disrupted behavior, promoting the establishment of depression [56,57] . The molecular pathway underlying this relationship is not yet understood, but a strong indication supporting this hypothesis is that the early changes in the composition of the gut microbiota can affect different aspects of brain function and behavior later in adulthood through the HPA axis and stress response [58] .…”

Section: The Interaction Of Microbiota and Neuroendocrine Systemmentioning

confidence: 99%

Cross-talk between the infant/maternal gut microbiota and the endocrine system: a promising topic of research

Turroni¹,

Rizzo²,

Ventura³

et al. 2022

Microbiome Res Rep

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The infant gut microbiota is the set of microorganisms colonizing the baby’s intestine. This complex ecosystem appears to be related to various physiological conditions of the host and it has also been shown to act as one of the most crucial determinants of infant’s health. Furthermore, the mother’s endocrine system, through its hormones, can have an effect on the composition of the newborn’s gut microbiota. In this perspective, we summarize the recent state of the art on the intricate relationships involving the intestinal microbiota and the endocrine system of mother/baby to underline the need to study the molecular mechanisms that appear to be involved.

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A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants

Cited by 28 publications

References 50 publications

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

Impact of Nutrition, Microbiota Transplant and Weight Loss Surgery on Dopaminergic Alterations in Parkinson’s Disease and Obesity

Cross-talk between the infant/maternal gut microbiota and the endocrine system: a promising topic of research

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