Cross-talk between the infant/maternal gut microbiota and the endocrine system: a promising topic of research

Turroni, Francesca; Rizzo, Sonia Mirjam; Ventura, Marco; Bernasconi, Sergio

doi:10.20517/mrr.2021.14

Cited by 7 publications

(4 citation statements)

References 83 publications

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“…Consequently, the increased circulating cortisol affects maternal gut microbiota. Cortisol can cross the placental barrier, increasing the circulating levels in the fetus and resulting in dysregulation of the HPA axis [ 93 ].…”

Section: Factors Affecting Maternal Gut Microbiota During Pregnancy: ...mentioning

confidence: 99%

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

Sajdel-Sulkowska

2023

Microorganisms

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Gut microbiota plays a critical role in physiological regulation throughout life and is specifically modified to meet the demands of individual life stages and during pregnancy. Maternal gut microbiota is uniquely adapted to the pregnancy demands of the mother and the developing fetus. Both animal studies in pregnant germ-free rodents and human studies have supported a critical association between the composition of maternal microbiota during pregnancy and fetal development. Gut microbiota may also contribute to the development of the fetal gut–brain axis (GBA), which is increasingly recognized for its critical role in health and disease. Most studies consider birth as the time of GBA activation and focus on postnatal GBA development. This review focuses on GBA development during the prenatal period and the impact of maternal gut microbiota on fetal GBA development. It is hypothesized that adaptation of maternal gut microbiota to pregnancy is critical for the GBA prenatal development and maturation of GBA postnatally. Consequently, factors affecting maternal gut microbiota during pregnancy, such as maternal obesity, diet, stress and depression, infection, and medication, also affect fetal GBA development and are critical for GBA activity postnatally. Altered maternal gut microbiota during gestation has been shown to have long-term impact postnatally and multigenerational effects. Thus, understanding the impact of maternal gut microbiota during pregnancy on fetal GBA development is crucial for managing fetal, neonatal, and adult health, and should be included among public health priorities.

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Section: Factors Affecting Maternal Gut Microbiota During Pregnancy: ...mentioning

confidence: 99%

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

Sajdel-Sulkowska

2023

Microorganisms

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“…It is thought to be established by breastfeeding and exposure during birth through the birth canal. 30 31 Bioactive components of human breast milk, oligosaccharides, which are non-digestible carbohydrates forming the third largest solid component in human milk particularly are significantly important to shaping infant gut microbiota by nurturing the beneficial bacteria. 32 Antimicrobial agents in breast milk also inactivate pathogens individually, additively and synergistically.…”

Section: Introductionmentioning

confidence: 99%

Preventive effect of prenatal maternal oral probiotic supplementation on neonatal jaundice (POPS Study): A protocol for the randomised double-blind placebo-controlled clinical trial

Alemu,

Lee,

Leung

et al. 2024

BMJ Open

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IntroductionNeonatal jaundice is a common and life-threatening health problem in neonates due to overaccumulation of circulating unconjugated bilirubin. Gut flora has a potential influence on bilirubin metabolism. The infant gut microbiome is commonly copied from the maternal gut. During pregnancy, due to changes in dietary habits, hormones and body weight, maternal gut dysbiosis is common, which can be stabilised by probiotics supplementation. However, whether probiotic supplements can reach the baby through the mother and reduce the incidence of neonatal jaundice has not been studied yet. Therefore, we aim to evaluate the effect of prenatal maternal probiotic supplementation on the incidence of neonatal jaundice.Methods and analysisThis is a randomised double-blind placebo-controlled clinical trial among 94 pregnant women (47 in each group) in a tertiary hospital in Hong Kong. Voluntary eligible participants will be recruited between 28 and 35 weeks of gestation. Computer-generated randomisation and allocation to either the intervention or control group will be carried out. Participants will take either one sachet of Vivomixx (450 billion colony-forming units per sachet) or a placebo per day until 1 week post partum. Neither the study participants nor researchers will know the randomisation and allocation. The intervention will be initiated at 36 weeks of gestation. Neonatal bilirubin level will be measured to determine the primary outcome (hyperbilirubinaemia) while the metagenomic microbiome profile of breast milk and maternal and infant stool samples as well as pregnancy outcomes will be secondary outcomes. Binary logistic and linear regressions will be carried out to assess the association of the microbiome data with different clinical outcomes.Ethics and disseminationEthics approval is obtained from the Joint CUHK-NTEC Clinical Research Ethics Committee, Hong Kong (CREC Ref: 2023.100-T). Findings will be published in peer-reviewed journals and presented at international conferences.Trial registration numberNCT06087874.

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“…Even though the interaction between HMOs and bifidobacteria has been extensively studied in recent years, there are other compounds in human milk, such as hormones, that may influence the neonatal gut microbiota ( 21 ). In this context, given that it is well recognized that human milk-associated hormones play a crucial role in influencing infant health ( 22 – 27 ), it is somewhat surprising that the interaction between these hormones and bifidobacteria that colonize the neonatal gut is still essentially unexplored. Therefore, to unravel the molecular interactions between human milk hormones and bifidobacteria, we investigated the impact of insulin on members of the genus Bifidobacterium .…”

Section: Introductionmentioning

confidence: 99%

Exploring Molecular Interactions between Human Milk Hormone Insulin and Bifidobacteria

et al. 2023

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Cross-talk between the infant/maternal gut microbiota and the endocrine system: a promising topic of research

Cited by 7 publications

References 83 publications

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

Preventive effect of prenatal maternal oral probiotic supplementation on neonatal jaundice (POPS Study): A protocol for the randomised double-blind placebo-controlled clinical trial

Exploring Molecular Interactions between Human Milk Hormone Insulin and Bifidobacteria

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