A preliminary pharmacognostical study on leaves and flowers of Michelia champaca L. Magnoliaceae

Geetha, K.; Jeyaprakash, K.; Nagaraja, Y. P.

doi:10.31018/jans.v3i2.184

Cited by 4 publications

(2 citation statements)

References 6 publications

(5 reference statements)

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“…Cancer is characterized by uncontrolled cell division by overcoming the signalling pathways involved in normal cell proliferation leading to apoptosis, extensive angiogenesis and metastasis. If the cell cycles particular checkpoints are targeted then it may provide lead for novel method of treatment [10]. The regulatory proteins, cyclins and their effector counterparts the cyclin dependant kinases have been identified as prominent targets in cell cycle mechanism.…”

Section: Introductionmentioning

confidence: 99%

In silico Study of Chromane Ring Compound Rubranonoside from Plumeria rubra as Anticancer Potential

Surana¹,

Mahajan²

2022

Trends Sci

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Plumeriarubra is an ornamental tree of Apocynaceae family. Plumeria rubra is a flowering plant. Flowers are very fragrant, commonly red pink or purple middle rich with yellow. Cancer is characterized through uncontrolled cell division through overcoming the numerous cell signalling pathways. Thus targeting the signalling pathway at various sites can lead to development of potential anticancer molecules. With this rational CDK2 receptors involved in cell cycle pathway was selected for the purpose of in silico analysis. Natural Products has a renowned history in cancer therapeutics. Plant derived anticancer leads have been reported since 1950. Extensive literature survey suggested that Plumeria rubra is explored for their chemical constituents along with their anticancer potential. Reported phytoconstituent i.e. rubranonoside of this plant was subjected to docking to summarise the docking scores, hydrogen bond, electrostatic bond and various decesive factors governing the protein ligand interaction. This report can be helpful further in designing in vitro and in vivo evaluations of the anticancer activity of rubranonoside. HIGHLIGHTS Molecular docking studies suggested that rubranonoside may be potential anticancer activity In silico pharmacokinetic parameters of rubranonoside were studied selected receptor Drug like properties of rubranonoside also calculated by Qikprop Rubranonoside interacting with amino acids LYS20, LEU83, ASN132, ASP143 GRAPHICAL ABSTRACT

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Section: Introductionmentioning

confidence: 99%

In silico Study of Chromane Ring Compound Rubranonoside from Plumeria rubra as Anticancer Potential

Surana¹,

Mahajan²

2022

Trends Sci

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“…according to the book "The Tretise of Indian Medicinal plants" 5 Preliminary phytochemical analysis of various extracts of Michelia champaca L. leaves and flowers showed the presence of alkaloids, tannins, glycosides, carbohydrates, amino acids, flavonoids and sterols. 6 Antibacterial and free radical scavenging activity of Michelia champaca L. was done on its flowers. In this study hexane and ethyl acetate extract showed strong antioxidant activity with IC50 values of both extracts were found to be 10µg/ml and 250 µg/ml respectively.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Phytochemical Screening of Michelia Champaca L. Flowers

Sinha¹,

Varma²

2019

Int Res J Pharm

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Michelia champaca L. is an evergreen, small to medium sized tree. It is commonly known as Swarna champa or Kanak champa. Present study was conducted to test the antioxidant potential and phytochemical analysis of its flowers. Antioxidant activity was evaluated in-vitro by DPPH radical scavenging assay and reducing power assay. Highest activity was shown by methanol extract of flowers at 150µg/ml concentration in both DPPH assay and reducing power assay. Inhibition concentration 50% value of methanol was found to be 1.73 µg/ml and which is similar to standard ascorbic acid. A good correlation was also found to exist between percentage inhibition and concentration of extract with value r 2 = 0.9951 and r 2 = 0.9357 in DPPH and reducing power assay respectively. Phytochemical analysis of the methanol extract showed the presence of carbohydrates, alkaloids, flavonoids, triterpenoids, steroids and tannins.

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Exploring Nephroprotective Properties of <i>Wedelia chinensis: In Vitro, In Silico,</i> and <i>In Vivo</i> Investigations

Gautam,

Venkatachalam,

Senthilkumar

2024

JNR

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The purpose of this research work is to investigate the nephroprotective efficacy of Wedelia chinensis leaf extracts against gentamicin-induced nephrotoxicity for in vitro, in silico, and in vivo techniques. The extracts of Wedelia chinensis leaf rich in flavonoids were subjected to an in silico method for ligands and target proteins. The results of the in vitro antioxidant study of extracts were tested for cytoprotective MTT assay and anti-inflammatory efficacy by protein denaturation assay using Human Embryonic Kidney cells (HEK293). The in vivo nephroprotective potential of the extract was evaluated with the two doses of 250mg/kg and 500mg/kg body weight in gentamicin nephrotoxicity in rats. The biochemical parameters observed for changes in the histopathology of the kidney. While comparing with other extracts of Wedelia chinensis Hydroalcoholic Extract (WCHAE) shows great binding affinity with bonding interactions of flavonoids and phenolics-based ligands observed with the target proteins that provided early information. The in vitro cell lines study revealed no cytotoxicity and better anti-inflammatory effect on HEK293 cells with cytoprotective and nephroprotective efficacy of WCHAE. The in vivo nephroprotective activity improved at a dose of 500mg/kg of WCHAE than Wedelia chinensis Ethanolic Extract (WCEE). The histopathological findings revealed the improvement in gentamicin-induced renal toxicity by the WCHAE orally treated group compared to normal and negative control groups. These results of WCHAE are more satisfactorily effective than WCEE with marked in vitro antioxidant, and cytoprotective effects in HEK293 cells. In in silico docking, it shows good interaction scores of ligands for target proteins like (kidney injury molecule) KIM-1 and Neutrophil Gelatinase-Associated Lipocalin (NAGAL) that helps to correlate nephroprotective potential benefits of antioxidants in plant extracts against gentamicin induced nephrotoxicity in rats.

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A preliminary pharmacognostical study on leaves and flowers of Michelia champaca L. Magnoliaceae

Cited by 4 publications

References 6 publications

In silico Study of Chromane Ring Compound Rubranonoside from Plumeria rubra as Anticancer Potential

In silico Study of Chromane Ring Compound Rubranonoside from Plumeria rubra as Anticancer Potential

Antioxidant Activity and Phytochemical Screening of Michelia Champaca L. Flowers

Exploring Nephroprotective Properties of <i>Wedelia chinensis: In Vitro, In Silico,</i> and <i>In Vivo</i> Investigations

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