A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis

Kurosaki, Masayuki; Matsunaga, Kotaro; Hirayama, Itsuko; Tanaka, Tomohiro; Sato, Mitsuaki; Yasui, Yutaka; Tamaki, Nobuharu; Hosokawa, Takanori; Ueda, Ken; Tsuchiya, Kaoru; Nakanishi, Hiroyuki; Ikeda, Hiroki; Itakura, Jun; Takahashi, Yuka; Asahina, Yasuhiro; Higaki, Megumu; Enomoto, Nobuyuki; Izumi, Namiki

doi:10.1111/j.1872-034x.2009.00607.x

Cited by 60 publications

(61 citation statements)

References 37 publications

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“…There are many different classification tools, including neural networks, Bayesian networks, and support vector machines, but models based on these may be more difficult to interpret or apply in clinical practice. On the other hand, decision tree approaches such as C4.5 and CART are widely used in biomedical studies [37][38][39] and provide a simple and intuitive hierarchical format that in many cases can be used without a computer.…”

Section: Discussionmentioning

confidence: 99%

Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

et al. 2011

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“…The results of the analysis are presented as a tree structure, which is intuitive and facilitates the allocation of patients into subgroups by following the flow chart form [20]. We have recently reported the usefulness of decision tree analysis for the prediction of early virological response (undetectable HCVRNA within 12 weeks of therapy) to PEG-IFN and RBV combination therapy in chronic hepatitis C [21].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis

et al. 2010

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“…Moreover, they added that GGT is a biochemical marker with low cost that may be incorporated with other predictive pretreatment factors. RVR and EVR are described in the study Kurosaki et al (2010) (E2) . The authors used the decision tree model (CART -The Classification and Regression Tree), which analyzes the predictors of response to therapy with PEG-IFN and RBV.…”

Section: Characteristics Of Therapeutic Response Of the Sr Studiesmentioning

confidence: 99%

GAMMA GLUTAMYLTRANSFERASE IMPACT IN THERAPEUTIC RESPONSE OF CHRONIC HEPATITIS C: a systematic review of the literature

Queiroga

Paraná

Filho

et al. 2015

Arq. Gastroenterol.

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-Background -The standard treatment of chronic hepatitis C is the administration of pegylated interferon α2a or α2b in combination with ribavirin, but adverse effects can be observed, as well as the high cost of this therapy. Therefore, there is interest in understanding the predictors of sustained virologic response, as the gamma glutamyltransferase. Objective -To evaluate the serum levels of gamma glutamyltransferase as a predictor of response to treatment with pegylated interferon α and ribavirin in chronic hepatitis C. Methods -This is a systematic review of literature, conducted by consulting PUBMED, LILACS, MEDLINE, SCOPUS, Cochrane electronic databases, and active search of articles selected between January 2000 and April 2013. Results -A total of 4,785 titles were iden tified. Out of those material, following inclusion and exclusion criteria, 273 abstracts were selected, by two independent researchers. After reading those texts, the reviewers consensually included ten studies for systematization and classification, according to the criteria of the Oxford Scale. 1B studies are predominant (prospective cohort study -six studies). Rapid virologic response and early virological response were considered as estimates for the sustained virological response. The frequency of virologic response was identified in three studies and early virological response in two, with a total of 392 and 413 patients, respectively; sustained virologic response was reported in nine articles corresponding to 3,787 patients (76.5 %). Conclusion -Gamma glutamyltransferase is a predictor of sustained virologic response in the treatment of chronic hepatitis C with pegylated interferon α2a or α2b associated with ribavirin. HEADINGS -Gamma glutamyltransferase. Hepatitis C. Sustained virological response. Review.

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A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis

Cited by 60 publications

References 37 publications

Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis

GAMMA GLUTAMYLTRANSFERASE IMPACT IN THERAPEUTIC RESPONSE OF CHRONIC HEPATITIS C: a systematic review of the literature

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