Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

Chayama, Kazuaki; Hayes, C. Nelson; Yoshioka, Kentaro; Moriwaki, Hisataka; Okanoue, T.; Sakisaka, Shotaro; Takehara, Tetsuo; Oketani, Makoto; Toyota, Joji; Izumi, Namiki; Hiasa, Yoichi; Matsumoto, Akihiro; Nomura, Hideyuki; Seike, Masataka; Ueno, Yoshiyuki; Yotsuyanagi, Hiroshi; Kumada, Hiromitsu

doi:10.1007/s00535-010-0358-6

Cited by 13 publications

(10 citation statements)

References 40 publications

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“…Nonetheless, supporting this assumption is the significantly greater enrichment in gt-1 patients of both cold-precipitating material with IgM molecules showing RF activity and HCV-Cp, as in this form of MCG, the RNA-to-Cp ratio is higher. It is well known that the genetic variability of HCV affects the metabolism of infected liver cells and influences the outcome of infection [41]. In addition, the RNA chaperone activity of core protein includes genomic RNA dimerization, which may constitute the regulatory switch determining translation/replication versus replication/packaging of viral RNA [42].…”

Section: Discussionmentioning

confidence: 99%

Assessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemia

et al. 2014

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IntroductionIn hepatitis C virus (HCV)-related mixed cryoglobulinemia (MCG), the nonenveloped HCV core protein (HCV-Cp) is a constituent of the characteristic cold-precipitating immune complexes (ICs). A possible correlation between HCV-Cp, virologic, laboratory, and clinical parameters in both untreated MCG patients and those undergoing specific treatment was explored.MethodsHCV-Cp was quantified by a fully automated immune assay. Correlations between HCV-Cp and HCV RNA, cryocrit, and virus genotype (gt) were investigated in 102 chronically HCV-infected MCG patients.ResultsHCV-Cp concentrations strongly correlated with HCV RNA levels in baseline samples. An average ratio of 1,425 IU and 12,850 IU HCV RNA per picogram HCV-Cp was estimated in HCV gt-1 and gt-2 patients, respectively. This equation allowed us to estimate that, on average, HCV-Cp was associated with the viral genome in only 3.4% of the former and in 35% of the latter group of patients. The direct relation between HCV-Cp and the cryocrit level suggests that the protein directly influences the amount of cryoprecipitate. Although the therapy with rituximab (RTX) as a single agent resulted in the enhancement of HCV-Cp levels, in patients treated with RTX in combination with a specific antiviral therapy (pegylated interferon-α plus ribavirin), the prompt and effective clearance of HCV-Cp was documented.ConclusionsOur data provide evidence that HCV-Cp has a direct effect on the cold-precipitation process in a virus genotype-dependence in HCV-related MCG patients.

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Section: Discussionmentioning

confidence: 99%

Assessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemia

et al. 2014

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“…In genotype 1, extending therapy improves the SVR rate in patients with delayed viral response (i.e., HCV-RNA becomes undetectable between 13 and 24 weeks after starting treatment). [14][15][16] These findings indicate that response-guided therapy is one of the most efficient methods for treatment. A recent meta-analysis showed that 72-week extended treatment improved the SVR rate in slow responders with HCV genotype 1.…”

Section: Introductionmentioning

confidence: 97%

Response‐guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2

Yamaguchi

Tamori

Tanaka

et al. 2012

Hepatology Research

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“…[14][15][16] This is an explicit, quantitative and systematic approach, and allows clinicians to maximize the net benefit to patients. 17 Recently, a decision-tree algorithm has been used to reveal the clinical feature profiles associated with sustained virological response to antiviral therapy against HCV 18,19 and disease progression of HCC. 20 The aim of this study is to investigate dietary profiles associated with HCV-PNALT using a decision-tree algorithm.…”

Section: Introductionmentioning

confidence: 99%

Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels

Otsuka¹,

Uchida

Kawaguchi³

et al. 2012

Hepatology Research

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Factors predictive of sustained virological response following 72 weeks of combination therapy for genotype 1b hepatitis C

Abstract: Complementary statistical and data mining approaches were used to identify a subgroup of patients likely to benefit from 72 weeks of therapy.

Cited by 13 publications

References 40 publications

Assessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemia

Assessment of total hepatitis C virus (HCV) core protein in HCV-related mixed cryoglobulinemia

Response‐guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2

Fish to meat intake ratio and cooking oils are associated with hepatitis C virus carriers with persistently normal alanine aminotransferase levels

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