2023
DOI: 10.1155/2023/3220235
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A Predictive Disease Risk Model for Ankylosing Spondylitis: Based on Integrated Bioinformatic Analysis and Identification of Potential Biomarkers Most Related to Immunity

Abstract: Background. The pathogenesis of ankylosing spondylitis (AS) is still not clear, and immune-related genes have not been systematically explored in AS. The purpose of this paper was to identify the potential early biomarkers most related to immunity in AS and develop a predictive disease risk model with bioinformatic methods and the Gene Expression Omnibus database (GEO) to improve diagnostic and therapeutic efficiency. Methods. To identify differentially expressed genes and create a gene coexpression network be… Show more

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“…This cytokine secretion ampli es systemic in ammation and facilitates the interaction with Innate Lymphoid Cell 3 (ILC3), implicating a vital link between gut immunity and systemic in ammatory pathways integral to AS pathogenesis (27)(28)(29). Additionally, the CX3CL1/CX3CR1 axis is implicated in chronic pain and bone resorption, suggesting a broader role in mediating the gut-joint in ammatory axis characteristic of AS (29)(30)(31)(32)(33). Furthermore, the activation and antigen-presenting capabilities of CD62L-CD86 + myeloid DCs are central to orchestrating an immune response that favors AS development.…”
Section: Discussionmentioning
confidence: 99%
“…This cytokine secretion ampli es systemic in ammation and facilitates the interaction with Innate Lymphoid Cell 3 (ILC3), implicating a vital link between gut immunity and systemic in ammatory pathways integral to AS pathogenesis (27)(28)(29). Additionally, the CX3CL1/CX3CR1 axis is implicated in chronic pain and bone resorption, suggesting a broader role in mediating the gut-joint in ammatory axis characteristic of AS (29)(30)(31)(32)(33). Furthermore, the activation and antigen-presenting capabilities of CD62L-CD86 + myeloid DCs are central to orchestrating an immune response that favors AS development.…”
Section: Discussionmentioning
confidence: 99%