Unraveling New Therapeutic Targets in Ankylosing Spondylitis: Multi-Omics Mendelian Randomization on Immune Cells, Metabolites, and Inflammation Proteins
Kai Du,
Ao Li,
Chen-Yu Zhang
et al.
Abstract:Objective: To identify novel immunological, metabolic, and inflammatory determinants of Ankylosing Spondylitis (AS) using Mendelian Randomization (MR), offering new insights into its pathogenesis and potential therapeutic interventions.
Methods: Employing a bidirectional, secondary validation two-sample MR (TSMR), this study investigated causal associations among 1,400 serum metabolites, 731 immune cell traits, and 91 circulating inflammatory proteins with AS. Instrumental variables (IVs) were identified using… Show more
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