A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes

Wang, Yanhan; Kao, Ming Shan; Yu, Jinghua; Huang, Stephen; Marito, Shinta; Gallo, Richard L.; Huang, Chun Ming

doi:10.3390/ijms17111870

Cited by 57 publications

(58 citation statements)

References 36 publications

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“…epidermidis isolates have been shown through an antagonism assay to possess antimicrobial activity against C. acnes [27, 56]. Among the S. epidermidis strains with an elevated antimicrobial activity, differences in inhibition zone diameter and appearance were observed, indicating that the antimicrobial substances were of a different nature.…”

Section: Resultsmentioning

confidence: 99%

“…In this perspective, studies indicate that S. epidermidis may control dysbiosis caused by C. acnes , thus reducing acne severity [27, 56]. However, it still remains unclear which SCFA in the products of S. epidermidis glycerol fermentation primarily contributes to the anti- C. acnes effect.…”

Section: Resultsmentioning

confidence: 99%

“…However, during puberty, over-colonisation of the pilosebaceous unit by C. acnes may lead to a loss of diversification and dysbiosis, potentially causing acne [6, 25-27]. A recent clinical study using the single-locus sequence typing method investigated C. acnes subgroups on the face and back in patients with severe acne and in healthy subjects [28].…”

Section: Resultsmentioning

confidence: 99%

“…Different antagonism investigations demonstrated that, in vivo, S. epidermidis controls the proliferation of C. acnes via the release of succinic acid, a fatty acid fermentation product, which inhibits surface TLRs of keratinocytes and tumour necrosis factor and suppresses C. acnes -induced IL-6 [27, 56, 58]. …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, live S. epidermidis may potentially be used as an active component in acne probiotics [27, 56]. …”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne?

Claudel¹,

Auffret²,

Leccia

et al. 2019

Dermatology

112

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Background: Cutibacterium acnes has been identified as one of the main triggers of acne. However, increasing knowledge of the human skin microbiome raises questions about the role of other skin commensals, such as Staphylococcus epidermidis, in the physiopathology of this skin disease. Summary: This review provides an overview of current knowledge of the potential role of S. epidermidis in the physiopathology of acne. Recent research indicates that acne might be the result of an unbalanced equilibrium between C. acnes and S. epidermidis,according to dedicated interactions. Current treatments act on C. acnesonly. Other treatment options may be considered, such as probiotics derived from S. epidermidis to restore the naturally balanced microbiota or through targeting the regulation of the host’s AMP mediators. Key Messages: Research seems to confirm the beneficial role of S. epidermidis in acne by limiting C. acnes over-colonisation and inflammation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Moreover, live S. epidermidis may potentially be used as an active component in acne probiotics [27, 56]. …”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne?

Claudel¹,

Auffret²,

Leccia

et al. 2019

Dermatology

112

View full text Add to dashboard Cite

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Skin Microbiome

Moreau

Zhen

2022

Cosmetic Dermatology

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Encapsulation of Commensal Skin Bacteria within Membrane‐in‐Gel Patches

Nouri

Demoustier‐Champagne

et al. 2022

Adv Materials Inter

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dermatitis, psoriasis, and acnes, considered to arise at least partly from an alteration of these bacterial communities. [2a,4] Staphylococcus epidermidis (S. epidermidis), a permanent member of the human skin microbiota, has been extensively studied because of its prevalence on skin sites and its numerous benefits to hosts. On the one hand, some strains of S. epidermidis have been shown to promote the production of antimicrobial peptides (AMPs) by keratinocytes, [5] and induce T-cell development, [6] resulting in the enhancement of the innate immune protection. The extent and duration of the immune response has also been reported to be controlled by S. epidermidis which diminishes excessive inflammation after injury. [7] On the other hand, diverse molecules, such as phenolsoluble modulins, [8] serine proteases, [9] and nucleobase analogs, [10] can be produced by specific strains of S. epidermidis, leading to the suppression of adjacent microorganism growth. S. epidermidis itself can also secrete AMPs, which have been shown to synergize with the innate immune response to protect the host against pathogens. [11] Therefore, instead of using antibiotics, which have the potential to cause bacterial resistance, bacteriotherapy has been advocated as a promising alternative to prevent skin colonization by pathogenic bacteria. [12] The introduction of S. epidermidis on patients' skin has been shown to significant reduce the colonization by S. aureus and group A Streptococcus. [8-9,11b,13] The short-chain fatty acids produced by S. epidermidis fermentation have been demonstrated to control the growth of Cutibacterium acnes, [11a,14] and of Propionibacterium acnes, [15] which are both important acne triggers.Human beings are colonized by a variety of S. epidermidis strains showing a diversity in pathogenicity. [16] For example, the non biofilm-forming strain ATCC 12228, which lacks the ica operon, [17] is a non-pathogenic commensal. However, some S. epidermidis strains are invasive and are major pathogens in nosocomial infections when they pass through the skin surface and enter the bloodstream via medical devices, for instance. For instance, 47% of coagulase-negative Staphylococci infections are due to S. epidermidis strains which often are methicillin-and multidrug-resistant. [18] Genomic analysis of both commensal and nosocomial strains demonstrate that they share approximately 80% of their genomes, with the 20%

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A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes

Cited by 57 publications

References 36 publications

<b><i>Staphylococcus epidermidis</i></b>: A Potential New Player in the Physiopathology of Acne?

<b><i>Staphylococcus epidermidis</i></b>: A Potential New Player in the Physiopathology of Acne?

Skin Microbiome

Encapsulation of Commensal Skin Bacteria within Membrane‐in‐Gel Patches

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