A Pragmatic Randomized Controlled Trial on the Effectiveness of Highly Concentrated Saline Spa Water Baths Followed by UVB Compared to UVB Only in Moderate to Severe Psoriasis

Brockow, Thomas; Schiener, R.; Franke, Annegret; Resch, K. L.; Peter, Ralf Uwe

doi:10.1089/acm.2007.7099

Cited by 32 publications

(41 citation statements)

References 24 publications

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“…The results of the second trial, involving 143 patients, indicated that BPT using low-concentration saline spa water baths followed by conventional UVB phototherapy was superior to conventional UVB monophototherapy at the end of a 6-week treatment course [8]. The same study group showed in another trial that psoriasis patients allocated to highly concentrated saline spa water baths plus UVB phototherapy for 6 weeks achieved a statistically significantly higher rate of PASI-50 than patients allocated to UVB only [9]. The concentration and mineral composition of the salt solution were thought to play a major role in BPT for psoriasis.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

et al. 2011

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Background/Aims: The exact mechanisms of action of balneophototherapy are incompletely understood. We aimed to investigate the effect of salt water soaks on ultraviolet (UV) transmission and the expression of molecular parameters of psoriasis. Methods: We studied UV transmission and the expression of antimicrobial peptides and skin-derived antileukoproteinase (SKALP/elafin) in psoriatic epidermis equivalents which were pretreated with tap water and differently concentrated salt water solutions. Moreover, we performed in vivo phototoxicity tests in healthy subjects. Results: Highly concentrated salt water soaks significantly increase UV transmission through psoriatic epidermis equivalents, in particular within the wavelength range of 305– 360 nm. In vivo tests revealed increased photosensitivity following highly concentrated salt water baths. A significant decrease in human β-defensin-2 (hBD-2) and SKALP/elafin is observed after highly concentrated NaCl soaks. Conclusion: An increase in UV transmission following highly concentrated salt water soaks likely causes enhanced UV gain within the viable epidermis. Moreover, our data indicate that salt water soaks seem to influence the protein profiles of hBD-2 and SKALP/elafin.

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Section: Introductionmentioning

confidence: 99%

The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

et al. 2011

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“…Für diese Modalität wurden Studien mit Behandlungsfrequenzen von zwei [181], drei [182][183][184][185][186], fünf [187,188] [191], zweimal [192][193][194], dreimal [147,184,195,196] oder 4 x/Wo [193,197] In mehreren kleinen [195,[199][200][201] sowie einer größeren nichtrandomisierten Studie [202] [197,212] treten jedoch mit ca. 5 % eher selten auf [197].…”

Section: Uv-b (Breitspektrum)unclassified

S3‐Leitlinie zur Therapie der Psoriasis vulgaris Update 2011

Nast¹,

Boehncke²,

Mrowietz³

et al. 2011

J Deutsche Derma Gesell

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“…On the other hand, Health Resort Medicine, Balneology, Medical Hydrology and Climatology are relevant parts of the health systems in many countries within and outside Europe (Germany, Austria, Poland, Hungary, France, Japan, and others), and health insurances refund health resort treatments, at least partly. Additionally, it should be noted that a great deal of scientific work on the physiological mechanisms of these therapies (Gutenbrunner et al 1999a(Gutenbrunner et al , b, 2001aFink et al 2001;Shehata et al 2006;Bender et al 2007;Braga et al 2008;Vaile et al 2008) and their clinical outcomes (Gutenbrunner et al 1997(Gutenbrunner et al , 2001bGundermann et al 1998;Gutenbrunner and Gundermann 1998;Fioravanti et al 2000;Franke et al 2000;van Tubergen et al 2001;Costantino and Lampa 2005;Costantino et al 2006;Cutovic et al 2006;Gusi et al 2006;Balint et al 2007;Bellometti et al 2007;Brockow et al 2007a;Eversden et al 2007;Evcik et al 2007;Fransen et al 2007;Franke et al 2007a; Karagülle et al 2007a;Lund et al 2008;Odabasi et al 2008;Silva et al 2008;Tomas-Carus et al 2008) has been published within the last decades (for an overview see Gutenbrunner and Hildebrandt 1998;Bender et al 2005;Gutenbrunner 2006); in particular, the number of randomised prospective controlled studies has grown recently (Forestier 2000;StraussBlasche et al 2000a;…”

Section: Introductionmentioning

confidence: 99%

A proposal for a worldwide definition of health resort medicine, balneology, medical hydrology and climatology

et al. 2010

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Health Resort Medicine, Balneology, Medical Hydrology and Climatology are not fully recognised as independent medical specialties at a global international level. Analysing the reasons, we can identify both external (from outside the field) and internal (from inside the field) factors. External arguments include, e.g. the lack of scientific evidence, the fact that Balneotherapy and Climatotherapy is not used in all countries, and the fact that Health Resort Medicine, Balneology, Medical Hydrology and Climatology focus only on single methods and do not have a comprehensive concept. Implicit barriers are the lack of international accepted terms in the field, the restriction of being allowed to practice the activities only in specific settings, and the trend to use Balneotherapy mainly for wellness concepts. Especially the implicit barriers should be subject to intense discussions among scientists and specialists. This paper suggests one option to tackle the problem of implicit barriers by making a proposal for a structure and description of the medical field, and to provide some commonly acceptable descriptions of content and terminology. The medical area can be defined as "medicine in health resorts" (or "health resort medicine"). Health resort medicine includes "all medical activities originated and derived in health resorts based on scientific evidence aiming at health promotion, prevention, therapy and rehabilitation". Core elements of health resort interventions in health resorts are balneotherapy, hydrotherapy, and climatotherapy. Health resort medicine can be used for health promotion, prevention, treatment, and rehabilitation. The use of natural mineral waters, gases and peloids in many countries is called balneotherapy, but other (equivalent) terms exist. Substances used for balneotherapy are medical mineral waters, medical peloids, and natural gases (bathing, drinking, inhalation, etc.). The use of plain water (tap water) for therapy is called hydrotherapy, and the use of climatic factors for therapy is called climatotherapy. Reflecting the effects of health resort medicine, it is important to take other environmental factors into account. These can be classified within the framework of the ICF (International Classification of Functioning, Disability and Health). Examples include receiving health care by specialised doctors, being well educated (ICF-domain: e355), having an environment supporting social contacts (family, peer groups) (cf. ICF-domains: d740, d760), facilities for recreation, cultural activities, leisure and sports (cf. ICF-domain: d920), access to a health-promoting atmosphere and an environment close to nature (cf. ICF-domain: e210). The scientific field dealing with health resort medicine is called health resort sciences. It includes the medical sciences, psychology, social sciences, technical sciences, chemistry, physics, geography, jurisprudence, etc. Finally, this paper proposes a systematic international discussion of descriptions in the field of Health Resort Medicine, Balneology, M...

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A Pragmatic Randomized Controlled Trial on the Effectiveness of Highly Concentrated Saline Spa Water Baths Followed by UVB Compared to UVB Only in Moderate to Severe Psoriasis

Abstract: The study indicates that HC-SSW-UVB are superior to routine UVB at the end of a 6-week treatment course.

Cited by 32 publications

References 24 publications

The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

S3‐Leitlinie zur Therapie der Psoriasis vulgaris Update 2011

A proposal for a worldwide definition of health resort medicine, balneology, medical hydrology and climatology

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