The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

Gambichler, Thilo; Demetriou, Christalla; Terras, Sarah; Bechara, F. G.; Skrygan, Marina

doi:10.1159/000332983

Cited by 15 publications

(29 citation statements)

References 54 publications

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“…Some studies indicate that the main therapeutic effect of climatotherapy at the Dead Sea can be attributed primarily to the sunshine and secondarily to the hypersaline seawater . Other studies show that balneotherapy with Dead Sea salt solution soaks in combination with NB‐UVB therapy is superior to NB‐UVB therapy alone , which could be attributed to increased photosensitivity of the skin to UV radiation . We do not think that explains the results in our study for two reasons.…”

Section: Discussioncontrasting

confidence: 61%

The Role of Th17/Tc17 Peripheral Blood T cells in Psoriasis and Their Positive Therapeutic Response

et al. 2013

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It is known that NB-UVB therapy can suppress a broad range of immune cells, but the additional effect of bathing in geothermal seawater still remains unclear. To study the influence of treatment on the expression of circulating immune cells contributing to the pathogenesis of psoriasis, six patients with psoriasis were treated with bathing in geothermal seawater two times daily combined with NB-UVB five times/week for 2 weeks and six patients were treated with NB-UVB therapy three times/week for 8 weeks. Disease severity (Psoriasis Area and Severity Index, PASI), chemokines, inflammatory cytokines, T cells and Toll-like receptors in the blood and skin samples were evaluated on enrolment (W0) and at 1 (W1), 3 (W3) and 8 (W8) weeks. Compared with healthy controls, psoriasis patients with active disease had significantly higher proportion of peripheral CLA+ T cells expressing CCR10 and CD103 and T cells with both Th1/Tc1 (CD4+/CD8+ IFN-c+ or TNF-a+ cells) and Th17/Tc17 (CD4+CD45R0+IL-23R+, CD4+/CD8+ IL-17A+ or IL-22+ cells) phenotypes. Both treatments gave a significant clinical effect; however, bathing in geothermal seawater combined with NB-UVB therapy was more effective than NB-UVB therapy alone. This clinical improvement was reflected by a reduction in circulating CLA+ peripheral blood T cells and by a decreased Th1/Th17 and Tc1/Tc17 inflammatory response. These findings suggest that the inflammatory response in psoriasis is predominantly driven by both CD4+ and CD8+ skin-homing tissue retaining T cells of the Th17/Tc17 lineages.

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Section: Discussioncontrasting

confidence: 61%

The Role of Th17/Tc17 Peripheral Blood T cells in Psoriasis and Their Positive Therapeutic Response

et al. 2013

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“…Furthermore, Gambichler et al . showed that high‐concentration salt solution significantly reduces antimicrobial peptides, like human beta defensin ‐ 2 (hBD‐2), that are usually over‐expressed in psoriasis, and it also decreases skin‐derived antileukoproteinase (SKALP/elafin), found in numerous inflammatory skin diseases .…”

Section: Discussionmentioning

confidence: 99%

Tomesa balneophototherapy in mild to severe psoriasis: a retrospective clinical trial in 174 patients

Cattaneo

Violetti

Tavecchio

et al. 2012

Photoderm Photoimm Photomed

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Psoriasis is a chronic inflammatory skin disease with a high social and psychological impact on the quality of life of patients. Tomesa balneophototherapy is based on bathing in a magnesium-rich salt solution combined with exposure to narrowband ultraviolet B phototherapy. We conducted a retrospective clinical trial on 174 patients affected by mild to severe psoriasis undergoing Tomesa balneophototherapy. The basal course consisted of three to five sessions per week for a total of 30 sessions. Subsequently, patients could continue with a maintenance course of one session per week for a total of 30 sessions. We recorded a significant reduction of the mean Psoriasis Area and Severity Index (PASI) index with an achievement of at least PASI 75 in 52.1% of the 119 patients who completed the basal course and an improvement of the 'quality of life' of patients. The good efficacy obtained by this treatment, and the psychological impact on the quality of life of patients, demonstrated that Tomesa balneophototherapy could be a good option for the treatment of a chronic disease associated with psychological distress, like psoriasis.

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“…10 This commercially available ELISA kit is designed to measure the concentration of hBD2 from human serum/plasma, or conditioned medium. The concentration of hBD2 was determined based on the standard curve.…”

Section: Elisamentioning

confidence: 99%

Expression of human β‐defensin‐2 in psoriatic epidermis models treated with balneophototherapy

Gambichler

Skrygan

2013

Acad Dermatol Venereol

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Both mono-treatment with salt water soaks and BPT of PEM result in altered expression of hBD2, whereas the effects observed are most prominent after BPT. hBD2 gene and protein expression is predominantly down-regulated following BPT indicating that this combined phototherapeutic regimen is superior to mono-UVB or salt water soaks alone with respect to normalization of hBD2 expression in psoriatic epidermis.

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The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

Cited by 15 publications

References 54 publications

The Role of Th17/Tc17 Peripheral Blood T cells in Psoriasis and Their Positive Therapeutic Response

The Role of Th17/Tc17 Peripheral Blood T cells in Psoriasis and Their Positive Therapeutic Response

Tomesa balneophototherapy in mild to severe psoriasis: a retrospective clinical trial in 174 patients

Expression of human β‐defensin‐2 in psoriatic epidermis models treated with balneophototherapy

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