A Practical Transamidation Strategy for the N-Deacylation of Amides

Han, Qun; Xu, Kun; Tian, Faming; Huang, Sheng-Yang; Zeng, Cheng‐Chu

doi:10.6023/cjoc202112007

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…However, the difficulty to remove the metal residues resulted from the metal catalysts largely limits the industrial use of these metal-catalyzed methodologies. To circumvent this limitation, many metal-free methodologies have been developed for the synthesis of N -heterocycles recently ( Preeti and Singh, 2021 ; Yang et al, 2021 ; Han et al, 2022 ; Yamamoto et al, 2022 ). Among them, the intramolecular C-H aminations are of high interest mainly because the prefunctionalized substrates are avoided ( Tan et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Metal-Free Synthesis of N-Heterocycles via Intramolecular Electrochemical C-H Aminations

Wang

Zheng

et al. 2022

Front. Chem.

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N-heterocycles are key structural units in many drugs, biologically interesting molecules and functional materials. To avoid the residues of metal catalysts, the construction of N-heterocycles under metal-free conditions has attracted much research attention in academia and industry. Among them, the intramolecular electrochemical C-H aminations arguably constitute environmentally friendly methodologies for the metal-free construction of N-heterocycles, mainly due to the direct use of clean electricity as the redox agents. With the recent renaissance of organic electrosynthesis, the intramolecular electrochemical C-H aminations have undergone much progress in recent years. In this article, we would like to summarize the advances in this research field since 2019. The emphasis is placed on the reaction design and mechanistic insight. The challenges and future developments in the intramolecular electrochemical C-H aminations are also discussed.

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Section: Introductionmentioning

confidence: 99%

Metal-Free Synthesis of N-Heterocycles via Intramolecular Electrochemical C-H Aminations

Wang

Zheng

et al. 2022

Front. Chem.

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Recent Advances in Lipase Catalyzed Multicomponent Reactions to Synthesize N‐Heterocycles

Budhiraja,

Ali,

Tyagi

2023

Asian J Org Chem

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Biocatalysis has been an emerging field in organic synthetic chemistry in recent years and significantly expanded the application of enzymes. Further, the concept of enzymatic promiscuity, where an enzyme catalyzes reactions beyond its natural function, has been recognized as a valuable phenomenon that can enhance the versatility of an enzyme as a biocatalyst. Recent advancements in organic synthesis, driven by the demand for more efficient and environmentally friendly processes, have led to the development of enzyme‐catalyzed multicomponent reactions such as Biginelli reaction, Hantzsch synthesis, Mannich, Ugi, etc. for the synthesis of N‐Heterocyclic compounds. While a number of enzymes have played an important role in this context, lipase enzyme is still indispensable due to its low cost, easy availability, and higher organic solvent tolerance. In particular, the immobilization of lipase enzyme on various supports enhances its stability, reusability, and efficiency in catalyzing organic transformation, which expands its role beyond traditional biocatalytic methods. In this review, we have mainly compiled the findings that highlight the synthetic applications of lipases in manufacturing several types of N‐containing heterocyclic compounds.

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A Practical Transamidation Strategy for the N-Deacylation of Amides

Cited by 2 publications

References 48 publications

Metal-Free Synthesis of N-Heterocycles via Intramolecular Electrochemical C-H Aminations

Metal-Free Synthesis of N-Heterocycles via Intramolecular Electrochemical C-H Aminations

Recent Advances in Lipase Catalyzed Multicomponent Reactions to Synthesize N‐Heterocycles

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