A Practical Guide to Drug Usage in Adult Patients With Impaired Renal Function

Bennett, William M.

doi:10.1001/jama.1970.03180080050010

Cited by 55 publications

(5 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first formula to estimate the glomerular filtration rate (GFR) on the basis of serum creatinine levels was proposed in 1957 by Paul Effersøe 1 to help physicians tailor drug dosing to individual renal function. 2 Since there, more than 20 different formulas have been introduced in clinical practice to monitor renal function over time and predict renal and cardiovascular risk in patients with chronic kidney disease 3 and diabetes, 4 and even in the general population. 5 Until the most recent years, the Cockroft-Gault 6 and the simplified, four-variable abbreviated Modification of Diet in Renal Disease (aMDRD) 7 equations have been by far the most widely used.…”

mentioning

confidence: 99%

The GFR and GFR decline cannot be accurately estimated in type 2 diabetics

Gaspari

Ruggenenti

Porrini

et al. 2013

Kidney International

138

View full text Add to dashboard Cite

There are no adequate studies that have formally tested the performance of different estimating formulas in patients with type 2 diabetes both with and without overt nephropathy. Here we evaluated the agreement between baseline GFRs, GFR changes at month 6, and long-term GFR decline measured by iohexol plasma clearance or estimated by 15 creatinine-based formulas in 600 type 2 diabetics followed for a median of 4.0 years. Ninety patients were hyperfiltering. The number of those identified by estimation formulas ranged from 0 to 24:58 were not identified by any formula. Baseline GFR was significantly underestimated and a 6-month GFR reduction was missed in hyperfiltering patients. Long-term GFR decline was also underestimated by all formulas in the whole study group and in hyper-, normo-, and hypofiltering patients considered separately. Five formulas generated positive slopes in hyperfiltering patients. Baseline concordance correlation coefficients and total deviation indexes ranged from 32.1% to 92.6% and from 0.21 to 0.53, respectively. Concordance correlation coefficients between estimated and measured long-term GFR decline ranged from -0.21 to 0.35. The agreement between estimated and measured values was also poor within each subgroup considered separately. Thus, our study questions the use of any estimation formula to identify hyperfiltering patients and monitor renal disease progression and response to treatment in type 2 diabetics without overt nephropathy.

show abstract

mentioning

confidence: 99%

The GFR and GFR decline cannot be accurately estimated in type 2 diabetics

Gaspari

Ruggenenti

Porrini

et al. 2013

Kidney International

138

View full text Add to dashboard Cite

show abstract

“…It is now generally recognized that renal failure or impaired renal function requires changes in the dosage regimen of many drugs to prevent drug accumulation and toxic effects (Bennett, Singer and Coggins, 1970). A rigorous pharmacokinetic approach for calculating individualized dosage regimens of rapidly distributed drugs for patients with impaired renal function has been presented recently (Dettli, 1970).…”

mentioning

confidence: 99%

Tubocurarine and Renal Failure

Gibaldi

Levy

Hayton

1973

Survey of Anesthesiology

View full text Add to dashboard Cite

Different observations concerning the duration of the neuromuscular blocking effect of tubocurarine in patients with renal failure have been rationalized by pharmacokinetic analysis. Computer simulations predict that absence of renal function will have little effect on the duration of action of relatively small single doses of tubocurarine but that the duration of action of large single doses and multiple doses will be prolonged significantly.

show abstract

“…With the possible exceptions of lincomycin, cephalothin, and cephaloridine, there appears to be a striking similarity between the filterability of the antibiotics studied here and their hemodialyzability (1), a resemblance which extends even to the observed disparities among the penicillin congeners. This lends further support to the hypothesis that diffusibility in water is the most important characteristic affecting the passage of antibiotics through cellulose membranes.…”

Section: Discussionmentioning

confidence: 56%

Selective Filtration of Antibiotics Through Collodion Membranes

Barza

Bergeron

Brusch

et al. 1973

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Marked differences were noted among 14 antibiotics in their filterability through collodion (nitrated cellulose) membranes. The findings could not be attributed to differences in molecular weight or degree of serum protein binding, although the latter factor imposed an additional restraint on the passage of certain agents. Poorly filtered antibiotics appeared to be absorbed by the collodion. Some of these observations might be accounted for by the known ability of nitrated cellulose to interact with anions. However, the extreme differences in filterability among the various penicillins and the very restricted passage of certain cationic antibiotics appeared to be better explained by intrinsic differences in the diffusibility of these agents through water. Although differential filtration offers a means of assaying samples containing certain mixtures of antibiotics, the degree of separation exhibited by collodion membranes is not sufficient to make them useful for clinical purposes.

show abstract

A Practical Guide to Drug Usage in Adult Patients With Impaired Renal Function

Cited by 55 publications

References 56 publications

The GFR and GFR decline cannot be accurately estimated in type 2 diabetics

The GFR and GFR decline cannot be accurately estimated in type 2 diabetics

Tubocurarine and Renal Failure

Selective Filtration of Antibiotics Through Collodion Membranes

Contact Info

Product

Resources

About