A PPAR-alpha agonist gemfibrozil ameliorates cognitive and memory impairments in a sporadic Alzheimer's disease rat model

Yıldız, Şule; Çam, Muhammet Emin; Keleş, Rüstem; Hazar‐Yavuz, Ayse Nur; Kabasakal, Levent

doi:10.1016/j.euroneuro.2018.11.419

Cited by 2 publications

(2 citation statements)

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“…MWM test was performed to rats for evaluating spatial learning (59). There was a decrease in latency to find the platform underwater in all groups during the training phase.…”

Section: Discussionmentioning

confidence: 99%

Camellia Sinensis Leaves Hydroalcoholic Extract Improves the Alzheimer’s Disease-Like Alterations Induced by Type 2 Diabetes in Rats

Çam¹

2020

Clinical and Experimental Health Sciences

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Objective: Novel investigations have confirmed that hyperglycemia is strictly associated with the development of cognitive impairment and dementia. Sodium-dependent glucose transporter (SGLT) inhibitors, which are oral antidiabetic drugs, are currently being investigated as the medication in Alzheimer's disease (AD). In our study, Camellia sinensis (green tea), which inhibits sodium-dependent glucose transporter-1 (SGLT-1), was used in the treatment of type 2 diabetes mellitus (T2DM)-induced AD-like alterations via its antidiabetic effects.Methods: High-fat diet/streptozotocin-treated rat model was chosen to provide T2DM-induced AD-like alterations. Antidiabetic effects were evaluated with the measurement of blood glucose level (BGL), oral glucose tolerance test (OGTT), and insulin tolerance test (ITT). On the other hand, novel object recognition test (NORT), open field test (OFT), passive avoidance test (PAT), and Morris's water maze (MWM) test were performed to investigate the anti-Alzheimer's effects of C. Sinensis.Results: C. sinensis tolerated BGL for a short time but metformin, the first medication prescribed for T2DM, tolerated BGL during the test for 120 min. C. sinensis increased the number of square crosses and the frequency of grooming activity in a similar manner to metformin in OFT. C. sinensis treatment improved exploratory behavior and memory retention components in NORT. The step-through latency decreased in HFD/ STZ-treated rat model but it improved with metformin and C. sinensis treatment in PAT. According to the results obtained by the MWM test, C. sinensis treatment slightly improved learning. Conclusion:C. sinensis improved short-term memory and increased the locomotor activity in rats according to the results obtained by NORT, OFT, and PA.

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“…MWM test was performed to rats for evaluating spatial learning (59). There was a decrease in latency to find the platform underwater in all groups during the training phase.…”

Section: Discussionmentioning

confidence: 99%

Camellia Sinensis Leaves Hydroalcoholic Extract Improves the Alzheimer’s Disease-Like Alterations Induced by Type 2 Diabetes in Rats

Çam¹

2020

Clinical and Experimental Health Sciences

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“…This disease is expressed by the presence of β-amyloid plaque, intracellular neurofibrillary tangles (NFTs), synaptic deterioration and neuronal death. Although various drugs (rivastigmine, galantamine, donepezil, memantine, tacrine) are used for the treatment of AD, their success in completely eliminating symptoms is low (Colovic, Krstić, Lazarević-Pašti, Bondžić, & Vasić, 2013;Ulep, Saraon, & McLea, 2018;Yildiz, Cam, Keles, Hazar-Yavuz, & Kabasakal, 2019).…”

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confidence: 99%

Phenolic compounds, biological activities and trace elements of Capparis ovata var. canescens

Taşkın

Çam

et al. 2020

RBT

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Introduction: Capparis species (Capparaceae), also called caper, grow naturally in various regions of the world. Caper is a plant with medicinal and aromatic properties. Flower buds, root bark, and fruits of the plant are used in folk medicine due to their analgesic, wound healing, cell regeneration, tonic, and diuretic effects. Objective: The aim of this research was to evaluate in vitro (anti-urease, antioxidant, anticholinesterase) and in vivo (anti-inflammatory) biological activities of caper (C. ovata var. canescens). In addition, we aimed to identify its major phenolic compounds using high performance liquid chromatography with a photodiode array detector (HPLC-DAD) and confirmate them using quadrupole time-of-flight liquid chromatography with tandem mass spectrometry (Q-TOF-LC/MS). Also, we quantified the concentrations of several trace and major elements in plant samples using inductively coupled plasma-mass spectrometry (ICP-MS). Methods: The antioxidant, anti-urease and anticholinesterase activities of different plant extracts were evaluated using DPPH, FRAP, ABTS/TEAC, Indophenol and Ellman tests. The identification of phenolic compounds and trace element contents was performed using HPLC and Q-TOF-LC/MS and ICP-MS. Results: Soxhlet methanol extract exhibited the strongest anti-urease, antioxidant (ABTS/TEAC) and anticholinesterase activity. Soxhlet and maceration methanol extracts demonstrated significant anti-inflammatory effect in the altered edema size after the second hour of carrageenan injection. The active phenolic compounds in Soxhlet methanol extract were identified as rutin, quercetin-hexoside-hexoside, quercetin-3-O-hexoside and kaempferol-3-O-rutinoside. In addition, the average concentrations of vanadium, chromium, manganese, cobalt, copper, nickel, arsenic, selenium, zinc and lead were within the permissible limits defined by WHO for medicinal plants. However, it was found that the concentrations of cadmium and iron were higher than the maximum permissible limits. Conclusion: Our results suggest that although caper has a strong biological activity, it should be consumed carefully due to the excess amount of cadmium and iron elements it contains.

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A PPAR-alpha agonist gemfibrozil ameliorates cognitive and memory impairments in a sporadic Alzheimer's disease rat model

Cited by 2 publications

References 5 publications

Camellia Sinensis Leaves Hydroalcoholic Extract Improves the Alzheimer’s Disease-Like Alterations Induced by Type 2 Diabetes in Rats

Camellia Sinensis Leaves Hydroalcoholic Extract Improves the Alzheimer’s Disease-Like Alterations Induced by Type 2 Diabetes in Rats

Phenolic compounds, biological activities and trace elements of Capparis ovata var. canescens

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