A potentiometric nonaqueous assay for barbiturates and their preparations

Acid-Base Titrations in Nonaqueous Solvents

“…Diphenan (4-benzylphenyl carbamate) and urethane can be determined by heating with O.LV perchloric acid for 0.5 and 1 hour, respectively, and back-titrating with triethylamine. Barbiturates in pharmaceutical preparations dissolved in chloroform and poly (ethylene glycol) 400 can be rapidly and accurately titrated with sodium methoxide (148).…”

Pharmaceuticals and Related Drugs

“…Barbituric acid derivatives produce an intense red-violet color with copper-pvridine reagent (256). Barbiturates can be titrated in a chloroform-polyethylene glycol 400 solvent system using sodium methoxide in methanol as titrant (488). Color reactions of thiobarbituric acid derivatives were reported (209) as W'ell as quantitative methods (549) for their determination.…”

Analysis of Barbiturate Salts in Various Dosage Forms by an Ion Exchange and Nonaqueous Titration Procedure**School of Pharmacy, North Dakota Agricultural College, Fargo

“…Swartz and Foss (3) titrated barbiturates, as free acids, in a polyethylene glycol 400 and chloroform mixture. Titration was effected potentiometrically with sodium methoxide.…”