The interest in nonaqueous chemistry is increasing as evidenced by the number of basic and analytical studies reported. During the past two years there has been a considerable advance in the understanding of acids, bases, and solvents. There has been some correlation of this information toward a scientific selection of a solvent and titrant for a specific analytical use.An increase in scope of acid-base titration in nonaqueous systems and some improvement in methodology have occurred, but the largest increase has been in specific applications.