A potential therapeutic role in multiple sclerosis for stigmast-5,22-dien-3β-ol myristate isolated from Capparis ovata

Acar, Ozden Ozgun; Gazioğlu, Işıl; Kolak, Ufuk; Şen, Alaattin; Topçu, Gülaçtı

doi:10.24190/issn2564-615x/2017/03.08

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…[ 37 ] The potential therapeutic activity of a natural plant steroid, Stigmast-5,22-dien-3b-ol myristate from C. ovata , has been tested and found to be a highly promising agent for MS treatment. [ 38 ] Nazıroğlu et al[ 39 ] studied the effects of C. ovata on lipid peroxidation, antioxidant levels, and electroencephalography recordings in epileptic rats stimulated with pentylenetetrazole (PTZ). In that study, it was stated that C. ovata provided protection against PTZ-induced brain oxidative toxicity by supporting the antioxidant redox system.…”

Section: Discussionmentioning

confidence: 99%

The effects of Capparis ovata seed oil on the healing of traumatic skin wounds

Celepli¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Capparis ovata contains alkaloids, lipids, polyphenols, flavonoids, and also is rich in antioxidants. Conventionally, in Turkey, the flower buds, root, bark, and fruits of C. ovata are used for their analgesic, anti-inflammatory, anti-rheumatism, tonic, and diuretic effects. The aim of this study was to examine the effect on wound healing of C. ovata seed oil (COSO), which is known to have antioxidant, anti-inflammatory, and antibacterial properties. METHODS: In the study, 20 Wistar albino female rats were randomly divided into two groups of 10 animals each. A standard full-thickness skin defect was created on the back area of the rats. In both groups, after cleaning the wounds with saline daily, no active substance other than saline was applied to the control group, while 1 cc/day COSO was applied to the wounds of the rats in the study group. On the post-operative 14 th day, the rats were reanesthetized and wound area measurements were made. Then, excision was performed to include 1 cm of intact tissue around the wound, which remained unhealed, and samples were taken for histopathological examination. RESULTS: The changes in wound areas showed that after 14 days, the improvement in the group treated with caper oil (32.78; 95% confidence interval, 17.21–48.36) was significantly higher than that of the control group (65.41; 95% confidence interval, 49.84–80.98) (p=0.009). The histopathological scores showed a significant difference between the groups in respect of epithelial formation, inflammation, and fibrosis development. No epithelial tissue formation was observed in the control group (90%), and more incomplete re-epithelization and focal epidermal hyperplasia were observed in the treatment group (60%). Fibrosis development was mild and weak (70%) in the control group and was evaluated as severe and intense (60%) in the treatment group. Perivascular edema was mild (50%) and vascularity was immature (60% – an indicator of neovascularization) in the treatment group. These histopathological results showed that the treatment group inflammation phase was completed and the proliferation phase started, as well as the effectiveness of the use of caper oil on epithelization, angiogenesis, and fibrosis, which are important histopathological parameters in the evaluation of wound healing compared to the control group. CONCLUSION: From the results of this study, it was concluded that COSO significantly enhances the healing of full-thickness skin wounds and this effect is primarily related to its anti-inflammatory effect.

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Section: Discussionmentioning

confidence: 99%

The effects of Capparis ovata seed oil on the healing of traumatic skin wounds

Celepli¹

2021

Ulus Travma Acil Cerrahi Derg

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LC–MS and GC‐MS Analyses on Green Algae Penicillus Capitatus: Cytotoxic, Antimicrobial and Anticholinesterase Activity Screening Enhanced by Molecular Docking & Dynamics and ADME Studies

Toraman,

Atasoy,

Şenol

et al. 2024

Chemistry & Biodiversity

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In this comprehensive screening study, the chemical composition, and cytotoxic, antimicrobial, and anticholinergic activities of the green algae Penicillus capitatus, collected from Antalya‐Türkiye, were determined as in vitro and in silico. GC‐MS analysis of the hexane extract revealed a high content of fatty acids, with hexadecanoic acid constituting half of the total fatty acid content. LC‐HRMS analysis of the DCM:MeOH extract identified ascorbic acid as the most abundant compound, followed by (‐)‐epigallocatechin and salicylic acid. The DCM:MeOH extract exhibited potent cytotoxicity against MDA‐MB‐231 and MCF7 breast cancer cell lines, outperforming doxorubicin with lower IC50 values and a higher selectivity index. Additionally, the extract demonstrated significant antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, along with selective inhibition of acetylcholinesterase (hAChE) over butyrylcholinesterase (hBChE). Molecular docking and dynamics studies revealed that apigenin‐7‐O‐glucoside and epigallocatechin form stable interactions with estrogen receptor alpha (ERα) and hAChE, suggesting their potential as inhibitors. In silico ADME studies indicated favorable pharmacokinetic profiles for the detected compounds, supporting their potential as drug candidates. The promising cytotoxic activity of the P. capitatus extracts, coupled with significant antimicrobial properties and selective hAChE inhibition, highlights their therapeutic potential for breast cancer treatment, infection management, and neurodegenerative disease intervention.

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