A potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl

Akdeniz, Mehmet; Yener, İsmail; Yılmaz, Mustafa Abdullah; Kandemir, Sevgi İrtegün; Tekin, Fatma; Ertaş, Abdülselam

doi:10.1016/j.indcrop.2021.113566

Cited by 11 publications

(6 citation statements)

References 36 publications

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“…The in‐depth studies also revealed the presence of β‐sitosterol and β‐sitosterol‐3‐ O ‐ d ‐glucopyranosyl‐6′‐mirystate as the bioactive constituents (Nono et al, 2014). A similar kind of observation has also been reported by (Akdeniz et al, 2021) describing the predominant existence of β‐sitosterol in both natural and cultivated Salvia multicaulis . β‐sitosterol has also been reported as a chief component in pomegranate and bitter gourd seed oil cold pressings exhibiting strong antioxidant effects (Yoshime et al, 2018).…”

Section: Other Pharmacological Properties Of β‐Sitosterolsupporting

confidence: 84%

“…A similar kind of observation has also been reported by (Akdeniz et al, 2021) describing the predominant existence of β-sitosterol in both natural and cultivated Salvia multicaulis. β-sitosterol has also been reported as a chief component in pomegranate and bitter gourd seed oil cold pressings exhibiting strong antioxidant effects (Yoshime et al, 2018).…”

Section: Antioxidantsupporting

confidence: 83%

Section: Neuroprotectivementioning

confidence: 91%

“…On the other hand, ethanol extracts of S. multicaulis exhibited a high level of inhibitory activity against BChE in contrast to AChE. Further, the chromatographic analysis revealed the presence of β‐sitosterol as a dominant component (Akdeniz et al, 2021). β‐sitosterol isolated form Cassia timorensis demonstrated moderate activity against AChE with 49.1% inhibition (Azman et al, 2020).…”

Section: Other Pharmacological Properties Of β‐Sitosterolmentioning

confidence: 99%

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Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Nandi,

Nag,

Khatua

et al. 2023

Phytotherapy Research

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Sterols, including β‐sitosterol, are essential components of cellular membranes in both plant and animal cells. Despite being a major phytosterol in various plant materials, comprehensive scientific knowledge regarding the properties of β‐sitosterol and its potential applications is essential for scholarly pursuits and utilization purposes. β‐sitosterol shares similar chemical characteristics with cholesterol and exhibits several pharmacological activities without major toxicity. This study aims to bridge the gap between phytochemistry and current pharmacological evidence of β‐sitosterol, focusing on its anticancer activity and other biomedical properties. The goal is to provide a comprehensive understanding of β‐sitosterol's potential for future translational approaches. A thorough examination of the literature was conducted to gather relevant information on the biological properties of β‐sitosterol, particularly its anticancer therapeutic potential. Various databases were searched, including PubMed/MedLine, Scopus, Google Scholar, and Web of Science using appropriate keywords. Studies investigating the effects of β‐sitosterol on different types of cancer were analyzed, focusing on mechanisms of action, pharmacological screening, and chemosensitizing properties. Modern pharmacological screening studies have revealed the potential anticancer therapeutic properties of β‐sitosterol against various types of cancer, including leukemia, lung, stomach, breast, colon, ovarian, and prostate cancer. β‐sitosterol has demonstrated chemosensitizing effects on cancer cells, interfering with multiple cell signaling pathways involved in proliferation, cell cycle arrest, apoptosis, survival, metastasis invasion, angiogenesis, and inflammation. Structural derivatives of β‐sitosterol have also shown anti‐cancer effects. However, research in the field of drug delivery and the detailed mode of action of β‐sitosterol‐mediated anticancer activities remains limited. β‐sitosterol, as a non‐toxic compound with significant pharmacological potential, exhibits promising anticancer effects against various cancer types. Despite being relatively less potent than conventional cancer chemotherapeutics, β‐sitosterol holds potential as a safe and effective nutraceutical against cancer. Further comprehensive studies are recommended to explore the biological properties of β‐sitosterol, including its mode of action, and develop novel formulations for its potential use in cancer treatment. This review provides a foundation for future investigations and highlights the need for further research on β‐sitosterol as a potent superfood in combating cancer.

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Section: Other Pharmacological Properties Of β‐Sitosterolsupporting

confidence: 84%

Section: Antioxidantsupporting

confidence: 83%

Section: Neuroprotectivementioning

confidence: 91%

Section: Other Pharmacological Properties Of β‐Sitosterolmentioning

confidence: 99%

See 2 more Smart Citations

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Nandi,

Nag,

Khatua

et al. 2023

Phytotherapy Research

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“…To the best of our knowledge, cholinesterase inhibitory activity of the S. sharifii , S. santolinifolia , S. reuterana , S. spinosa , S. palaestina , S. virgata , S. hypoleuca , and S. mirzayanii EOs are reported for the first time and those of S. sclarea , S. verticillata , S. multicaulis, and S. syriaca EOs were previously investigated [ 58 , 61 - 63 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical composition, cholinesterase, and α-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species

Gharehbagh,

Ebrahimi,

Dabaghian

et al. 2023

BMC Complement Med Ther

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Background The plants from Salvia genus contain widely distributed species which have been used in folk medicine as well as pharmaceutical and food industries. Methods The chemical composition of 12 native Iranian Salvia species (14 plants) was identified using gas chromatography-mass spectrometry (GC–MS). Also, the inhibitory activity of all essential oils (EOs) was evaluated toward α-glucosidase and two types of cholinesterase (ChE) using spectrophotometric methods. The in vitro α-glucosidase inhibition assay was performed by the determination of p-nitrophenol (pNP) obtained from the enzymatic dissociation of p-nitrophenol-α-D-glucopyranoside (pNPG) as the substrate. In vitro ChE inhibitory assay was conducted based on the modified Ellman’s procedure using the measurement of 5-thio-2-nitrobenzoic acid produced from the hydrolysis of thiocholine derivatives as the substrate, in the presence of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Results Totally, 139 compounds were detected and caryophyllene oxide and trans-β-caryophyllene were the most abundant compounds in all EOs. The yield of EOs extracted from the plants were also calculated in the range of 0.06 to 0.96% w/w. Herein, α-glucosidase inhibitory activity of 8 EOs was reported for the first time and among all, S. spinosa L. was found to be the most potent inhibitor (90.5 inhibition at 500 μg/mL). Also, the ChE inhibitory activity of 8 species was reported for the first time and our results showed that the BChE inhibitory effect of all EOs was more potent than that of AChE. The ChE inhibition assay indicated that S. mirzayanii Rech.f. & Esfand. collected from Shiraz was the most potent inhibitor (72.68% and 40.6% at the concentration of 500 μg/mL, toward AChE and BChE, respectively). Conclusions It seems that native Salvia species of Iran could be considered in the development of anti-diabetic and anti-Alzheimer's disease supplements.

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Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC–MS: Source species for valuable compounds with drug or drug potential

Akdeniz¹,

Yener

Dincel

et al. 2021

Biomedical Chromatography

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Public use of Salvia species and their importance in the scientific world is continually increasing. It is known that this use and the importance of Salvia species are mostly due to the terpenoid compounds that they contain. In this context, the terpenoid–steroid–flavonoid contents of extracts of six endemic Salvia (S. kurdica, S. pseudeuphratica, S. rosifolia, S. siirtica, S. cerino‐pruinosa var. cerino‐pruinosa and S. cerino‐pruinosa var. elazigensis) species prepared with different solvents were determined by gas chromatography–mass spectrometry. Within the framework of the ingredient analysis, content analysis of the ethanol extracts of the root, branch, leaf and flower parts of the species collected in the same period between 2015 and 2017 years was performed. In general, extracts prepared with chloroform and ethanol were found to contain a wide variety of compounds while petroleum ether extracts were found to contain much less varied compounds. In addition, in general, root extracts are richer in terpenoid compounds than aerial part extracts. Some species can be used as source species in terms of ferruginol, cryptanol, 6,7‐dehydroroyleanone, lup‐(20)29‐ene‐2α‐hydroxy‐3β‐acetate, salvigenin and β‐sitosterol contents (52,114.28, 75,979.08, 101,247.41, 40,071.29, 33,952.13 and 34,010.90 μg analyte/g extract, respectively).

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A potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl

Cited by 11 publications

References 36 publications

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

Chemical composition, cholinesterase, and α-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species

Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC–MS: Source species for valuable compounds with drug or drug potential

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