A potential role for resveratrol as a radiation sensitizer for melanoma treatment

Fang, Yujiang; Bradley, Moore J.; Cook, Kathryn M.; Herrick, Elizabeth; Nicholl, Michael B.

doi:10.1016/j.jss.2013.02.037

Cited by 53 publications

(61 citation statements)

References 41 publications

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“…Several articles reported that RSV enhances the radiosensitivity of cancer cell line suggesting a beneficial effect for patients ongoing radiotherapy (48)(49)(50)(51). In vitro study of Fang et al (52) showed that addition of RSV to cell culture following 1-4 Gy irradiation enhances radiation sensitivity of melanoma cells by inhibiting proliferation and promoting apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes

Dobrzyńska

Gajowik

Radzikowska

2015

MUTAGE

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The aim of the study was to investigate how coadministration of resveratrol (RSV) at different time after the start of irradiation influences the frequency of micronuclei (MN) in reticulocytes of bone marrow and peripheral blood, and if the RSV supplementation after termination of irradiation may influence the recovery process of damaged cells. Coadministration of RSV with 1-day delay after 1 Gy irradiation significantly decreased the levels of MN in bone marrow and in peripheral blood, whereas with 1-week delay, only in bone marrow reticulocytes. Above combined treatment did not improve the process of recovery. RSV supplementation with 1-day delay relatively to 0.5 Gy irradiation, significantly decreased the frequencies of MN, especially after coadministration with 28 mg/kg bw of RSV. Coadministration of RSV since eighth day did not influence the frequencies of MN compared to irradiated cells. The recovery process in the presence of RSV proceeded faster. Supplementation of RSV following initiation of irradiation is beneficial in case of irradiation with lower doses. RSV should be supplemented as soon as possible. Supplementation of RSV after termination of irradiation significantly speed up the recovery. Current results confirmed the ability of RSV to mitigate the effect of irradiation.

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Section: Discussionmentioning

confidence: 99%

The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes

Dobrzyńska

Gajowik

Radzikowska

2015

MUTAGE

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“…The effect of XRT in combination with RSV on radioresistant melanoma lines, SK-Mel-5 and HTB-65, has been studied by assessment of proliferation and apoptosis (Fang et al, 2013). In this study, clonogenic survival assay of these cells with variable dosage of radiation (0-4 Gy), in the presence or absence of RSV (0, 2, 10, 50 μM), revealed a concentration and dose-dependent reduction in the number of colonies of the SK-Mel-5 and HTB-65 cells.…”

Section: Skin Cancermentioning

confidence: 99%

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

Kma

2013

Asian Pacific Journal of Cancer Prevention

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Cancers will continue to be a threat to health unless they can be controlled by combinations of treatment modalities. In this review, evaluate the role of resveratrol (RSV) as a radiosensitizing agent was evaluated and underlying mechanisms holistically explored in different cancer models focusing on therapeutic possibilities. The ability of RSV to modify the effect of radiation exposure in normal and cancer cells has indeed been shown quite convincingly, the combination of RSV and IR exhibiting synergistic effects on different cancer cells. This is relevant since controlled exposure to IR is one of the most frequently applied treatments in cancer patients. However, radiotherapy (XRT) treatment regimes are very often not effective in clinical practice as observed in patients with glioma, prostate cancer (PCa), melanoma, for example, largely due to tumour radioresistant properties. Sensitization of IR-induced apoptosis by natural products such as RSV is likely to be relevant in cancer control and treatment. However, all cancers do not respond to RSV+IR in a similar manner. Therefore, for those such as the radioresistant PCa or melanoma cells, the RSV+IR regime has to be very carefully chosen in order to achieve effective and desirable outcomes with minimum toxicity to normal cells. They are reports that the highest concentration of 100 mM RSV and highest dose of 5 Gy IR are sufficient to kill cells by induction of apoptosis, indicating that RSV is effective in radiosensitizing otherwise radioresistant cells. In general, it has been shown in different cancer cells that RSV+XRT effectively act by enhancing expression of anti-proliferative and pro-apoptotic molecules, and inhibiting pro-proliferative and anti-apoptotic molecules, leading to induction of apoptosis through various pathways, and cell death. If RSV+XRT can suppress the signature of cancer stemness, enhance the radiosensitivity by either targeting the mitochondrial functionality or modulating the tumour necrosis factor-mediated or Fas-FasL-mediated pathways of apoptosis in different cancers, particularly in vivo, its therapeutic use in the control of cancers holds promise in the near future.

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“…O efeito da radioterapia (XRT) em combinação com Rsv em linhagens de melanoma radioresistentes, SK-Mel-5 e HTB-65, foi estudado através da avaliação da proliferação celular e apoptose (FANG et al, 2013). Neste estudo, o ensaio clonogênico destas células com dosagem variável de radiação, na presença ou ausência de Rsv revelou uma redução do número de colônias de SK-MEL-5 e células HTB-65 concentração e dose-dependente.…”

Section: Resultsunclassified

O potencial do resveratrol como quimioterápico para o câncer de pele: uma revisão

Zamin

Horn

2017

cmbio

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A potential role for resveratrol as a radiation sensitizer for melanoma treatment

Cited by 53 publications

References 41 publications

The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes

The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

O potencial do resveratrol como quimioterápico para o câncer de pele: uma revisão

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