The effect of<i>in vivo</i>resveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes

Dobrzyńska, Małgorzata M.; Gajowik, Aneta; Radzikowska, Joanna

doi:10.1093/mutage/gev084

Cited by 14 publications

(9 citation statements)

References 56 publications

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“…In agreement to our results, Dobrzynska et al 31 reported that irradiation and coadministration of RSV induced reduction in micronuclei in bone marrow and reticulocytes. Decrease in the DNA damage in mice reticulocytes might be attributed to proposed antioxidant mechanisms of RSV.…”

Section: Discussionsupporting

confidence: 94%

The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes

et al. 2017

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In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4′-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated. The results of the alkaline comet assay showed that RSV significantly inhibited radiation-induced DNA damage. We observed that RSV protects blood lymphocyte against radiation-induced damage in mice.

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Section: Discussionsupporting

confidence: 94%

The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes

et al. 2017

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“…In the present study, fractionated doses of 0.5 and 1 Gy administered to mice for 1 or 2 weeks induced MN both in the bone marrow and in peripheral blood RET. Induction of micronuclei in reticulocytes or polychromatic erythrocytes in mouse bone marrow or peripheral blood in vivo following irradiation were also observed previously at different doses and times of irradiation (Gandhi 2013; Bannister et al 2016; Dobrzyńska et al 2016). The frequency of micronuclei was similar for 0.5 Gy and lower for 1 Gy as compared to our earlier study, where the same doses of irradiation were used (Dobrzyńska et al 2016).…”

Section: Discussionsupporting

confidence: 75%

The effect of lycopene supplementation on radiation-induced micronuclei in mice reticulocytes in vivo

Dobrzyńska

Gajowik

Radzikowska

2019

Radiat Environ Biophys

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Lycopene (LYC) is a natural pigment present in tomatoes and other red fruits and vegetables including red carrots, red peppers, watermelons, pink grapefruits, apricots, pink guavas, and papaya. There is some evidence that LYC may provide protection against mutations induced by ionizing radiation. The study aimed to investigate whether the genetic material of reticulocytes (RET) could be protected from radiation-induced damage by LYC. Mice were treated with LYC [0.15 mg/kg bodyweight (bw), 0.30 mg/kg bw], acute and fractionated irradiation (0.5 Gy, 1 Gy applied daily), or with both agents (0.5 Gy + 0.15 mg/kg bw LYC, 0.5 Gy + 0.30 mg/kg bw LYC, 1 Gy + 0.15 mg/kg bw LYC, 1 Gy + 0.30 mg/kg LYC). LYC supplementation was started at 24 h or 1 week after the first irradiation. Irradiation significantly enhanced the frequency of micronuclei (MN) in RET. LYC treatment at a dose of 0.15 mg/kg bw 24 h after starting fractionated radiation at 1 Gy significantly decreased (41–68%, p < 0.0125) the level of MN in peripheral blood and bone marrow RET. LYC supplementation at 0.30 mg/kg bw did not significantly alter the frequency of MN in peripheral blood, but significantly increased the frequency of bone marrow RET MN. LYC treatment on day 8 following the first radiation exposure showed results similar (92–117%, p > 0.24) to those obtained with irradiation alone. Lycopene may act as a radiomitigator but must be administered at low doses and as soon as possible after irradiation. Contrary, combined exposure with high doses of irradiation and LYC may enhance the mutagenic effect of irradiation.

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“…A concentration of 50 mg/kg BW in mice corresponds a dose of 243-324 mg in adult humans weighting 60-80 kg [98,99], respectively, and these concentrations are in the range of the concentrations commonly used for human trials and stated to be safe [96,97]. In addition, these levels are below the highest commercially available single dose of about 500 mg per tablet or capsule [100]. In vitro concentrations of resveratrol are also varying from low of 0.03 µM [20] to high doses of 100-200 µM [19], depending on the in vitro models used.…”

Section: Discussionmentioning

confidence: 92%

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Bilotta

Arbogast

Schart

et al. 2022

IJMS

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Mast cells are involved in allergic and other inflammatory diseases. The polyphenol resveratrol is known for its anti-inflammatory properties and may be used as nutraceutical in mast cell associated diseases. We analyzed the effect of resveratrol on mast cells in vivo in ovalbumin-induced allergic enteritis as well as experimental colitis in IL-10−/− mice which received resveratrol via drinking water. Treatment with resveratrol prevented the increase in mast cells in both allergic enteritis and chronic colitis in duodenum as well as in colon. Further, it delayed the onset of diseases symptoms and ameliorated diseases associated parameters such as tissue damage as well as inflammatory cell infiltration in affected colon sections. In addition to the findings in vivo, resveratrol inhibited IgE-dependent degranulation and expression of pro-inflammatory cytokines such as TNF-α in IgE/DNP-activated as well as in LPS-activated bone marrow-derived mast cells. These results indicate that resveratrol may be considered as an anti-allergic and anti-inflammatory plant-derived component for the prevention or treatment of mast cell-associated disorders of the gastrointestinal tract.

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The effect ofin vivoresveratrol supplementation in irradiated mice on the induction of micronuclei in peripheral blood and bone marrow reticulocytes

Cited by 14 publications

References 56 publications

The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes

The Radioprotective Effect of Resveratrol Against Genotoxicity Induced by γ-Irradiation in Mice Blood Lymphocytes

The effect of lycopene supplementation on radiation-induced micronuclei in mice reticulocytes in vivo

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

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