A potential of some medicinal plants as an antiulcer agents

Abstract

Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. There are two major factors that can disrupt the mucosal resistance to injury: non-steroidal antiinflammatory drugs (NSAIDs) example, aspirin and Helicobacter pylori infection. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including peptic ulcer. There has been considerable pharmacological investigation into the antiulcer activity of some compounds. In this work, we shall review the literature on different medicinal plant and alkaloids with antiulcer activity. This article reviews the antiacid/anti-peptic, gastroprotective and/or antiulcer properties of the most commonly employed herbal medicines and their identified active constituents. The experimental parameters used for antiulcer activity were cold restraint stress-induced ulcer model, Diclofenac-induced ulcer model in rats, (HCl–ethanol)-induced ulcer in mice and water immersion stress-induced ulcer in rats. The ideal aims of treatment of peptic ulcer disease are to relieve pain, heal the ulcer and delay ulcer recurrence. About 70% of patients with peptic ulcer disease are infected by Helicobacter pylori and eradication of this microorganism seems to be curative for this disease. This article reviews drugs derived from medicinal plant more commonly used in the world for peptic ulcer and, if reported, the antiulcer activity. This article will be concerned only with the antiulcer and gastro-protective effects.

GC-MS Analysis and Gastroprotective Evaluations of Crude Extracts, Isolated Saponins, and Essential Oil from Polygonum hydropiper L.

“…Natural products, especially plants derived chemicals are considered as promising source for the development of new agents with safe therapeutic window (Atanasov et al, 2015 ). Traditional medicine using plants have been shown to be successful in the treatment of gastrointestinal disorders including peptic ulcer disease (Gadekar et al, 2010 ). Consequently, plant extracts stand out as the most promising substances in the search for new therapies for the treatment of gastric ulcer.…”

Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species

“…Taking together, it is plausible to speculate that α-pinene might contribute to the screening process and quality control of essential oils with gastroprotective effect obtained from Hyptis genus, a promising source of scientific research for novel agents to treat gastric ulcers. [ 43 ]…”

Bioactive indole alkaloids isolated from Alstonia angustifolia

“…Many Alstonia species are commercial timbers, and some species are also used as traditional medicines for the treatment of cough, ulcer, dysentery, fever, malaria, sore throats, toothache, rheumatism, and snake bites (Perry and Metzger, 1980; Sidiyasa, 1998; Gadekar, et al, 2010). Alstonia angustifolia Wall.…”