A potential human axonemal dynein heavy-chain gene maps to 17q25

Primary ciliary dyskinesia: a genome-wide linkage analysis reveals extensive locus heterogeneity

“…These include 13 axonemal heavy chain polypeptides, and 6 axonemal or cytoplasmic heavy, intermediate and light polypeptides. [35][36][37][38][39][40] No full length cDNA sequence of any of the human axonemal heavy chain dynein genes has yet been published and no deleterious mutations have been reported. The concordance of dynein mapping positions with the PCD linkages are found on chromosomes 3p (ZH = 1.37), 5p (ZH = 2.197, 2-point sib pairs p = 0.0071, Z-all max = 1.32), 8q (ZH = 1.49, multipoint Z-all max = 1.90) and 17q (ZH = 1.0, Z-all max = 1.40).…”

Dynein and dynein-related genes

“…Their sequence is 71% identical to the axonemal dynein ␤-heavy chain from sea urchins. In contrast to dynein heavy chain, one gene, DNEL1, consist of only ϳ3,200 bp, whereas the other, DNEL2, may encode the dynein heavy chain as judged by the size of the transcript from the Northern blot [Milisav and Affara, 1998]. Only some of its sequence, however, is known so far.…”

“…A high resolution map was obtained by the analysis of the radiation hybrid panel including the interval 17q22-q25.3 [Foster et al, 1996], which determined positions of the two genes in relation to already known markers at the chromosome 17q. Both genes are distal to thymidine kinase [Milisav et al, 1996;Milisav and Affara, 1998]. The physical distance between the markers DNEL1 and DNEL2 has not been determined, but may be ϳ2 mega base pairs if the distance between the markers in this region of chromosome 17 is similar to that at 17q24 [Foster et al, 1996].…”

The association between methylation patterns of DNAH17 and clinicopathological factors in hepatocellular carcinoma

“…14,15 However, the detailed mechanism of primary cilia in oncogenesis and tumor progression remains poorly understood. Dynein axonemal heavy chain 17 (DNAH17), which was initially mapped in 1998, 16 is a gene encoding a heavy chain associated with axonemal dynein. Recently, wholeexon sequencing of five paired hepatitis B virus-associated early-stage HCC samples found that DNAH17 was frequently mutated in HCC patients.…”