A Possible Role of CD4<sup>+</sup>CD25<sup>+</sup> T Cells as Well as Transcription Factor Foxp3 in the Dysregulation of Allergic Rhinitis

Xu, Geng; Mou, Zhonglin; Jiang, Hongyan; Cheng, Long; Shi, Jianbo; Xu, Rui; Oh, Yun; Li, Hua-Bin

doi:10.1097/mlg.0b013e318033f99a

Cited by 52 publications

(48 citation statements)

References 15 publications

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“…Such a reduced capacity of Tregs expressing lower levels of FoxP3 has been demonstrated in other diseases [26][27][28][29]. Recently, evidence supporting a mutual counter-regulation between T effector cells and regulatory T cells was presented.…”

Section: Foxp3mentioning

confidence: 95%

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

Idali

Wahlström

Müller-Suur

et al. 2008

Clinical and Experimental Immunology

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SummaryIn pulmonary sarcoidosis, the typical T helper 1-mediated immune response in the lungs has been proposed to be co-ordinated by regulatory T cells; however, their exact role needs to be clarified. We used real-time polymerase chain reaction to study genes involved in regulatory T cell functions in CD4 + AV2S3 -T cells. The main conclusion of our study is that there is a reduced expression of regulatory T cell associated genes in BALF CD4 + T cells in sarcoidosis. In addition, our data suggest an effector function of AV2S3 + lung-accumulated T cells in sarcoidosis.

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Section: Foxp3mentioning

confidence: 95%

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

Idali

Wahlström

Müller-Suur

et al. 2008

Clinical and Experimental Immunology

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“…Recently, different studies have started to highlight the link between allergy and defective immunoregulation; however, the results are inconsistent. Lee et al [20] and Xu et al [21] described a reduction of the Tregs compartment in patients with allergy. Zhang et al [22] found a significant decrease of Tregs only in acute exacerbation of asthma in comparison with chronic stable disease.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Activation of CD4+CD25high FoxP3+ Regulatory T Cells in Peripheral Blood from Children with Atopic Allergy

Stelmaszczyk-Emmel¹,

Zawadzka-Krajewska²,

Szypowska

et al. 2013

Int Arch Allergy Immunol

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Background: Atopic allergy is among the immune tolerance-related disorders resulting from a failure of the regulatory network. Regulatory T cells (Tregs) play a leading role in the development of homeostasis in the immune system. The aim of this study was to determine the role of Tregs in the pathogenesis of atopic diseases in children by exploring the relationship between Treg frequency, activation markers and the clinical manifestations of the disease. Methods: Twenty allergic and 50 healthy children were enrolled to the study. Peripheral blood mononuclear cells were stained with monoclonal antibodies (anti-CD25-CD4-CD127-FoxP3-CD69-CD71) and evaluated using flow cytometry. Tregs were identified as CD4+CD25^+/highFoxP3+CD127- T cells. Results: The percentage of Tregs in allergic patients (2.3%) was significantly decreased in comparison to healthy controls (4.6%, p = 0.003). The frequency of Tregs in patients with symptoms of atopic dermatitis and/or food allergy (1.7%) was significantly lower than in patients without these symptoms (2.9%, p = 0.04). A significant correlation between the percentage of Tregs and the sIgE serum concentration was observed (p = 0.037). Relative fluorescence intensities of FoxP3 expression in allergic patients were higher than in healthy controls (p = 0.00004). The frequency of CD4+CD25^highCD127-CD71+ cells did not differ between the groups. Conclusions: Tregs display substantial deficiencies in atopic children, especially in children with multiorgan involvement, compared to patients with single organ manifestations. Additionally, there is an association between Tregs and the sIgE serum concentration. Better identification and characterization of Tregs in allergy is needed as they limit responses to foreign antigens, thereby minimizing T cell-mediated immunopathology in allergic diseases.

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“…Although Treg cells are classically thought of as Th1 inhibitory cells due to their activity against Th1-mediated diseases such as rheumatoid arthritis and type 1 diabetes (22), Treg cells have also been demonstrated to inhibit Th2 responses (23). Importantly, lower numbers of Treg cells are found in patients with allergic rhinitis in comparison to controls (24). Furthermore, B cells play a critical role in IgE synthesis, and require two signals to synthesis IgE (25)(26)(27).…”

mentioning

confidence: 99%

Novel Vaccination for Allergy through Gene Silencing of CD40 Using Small Interfering RNA

Suzuki

Zheng

Zhang

et al. 2008

The Journal of Immunology

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Small interfering RNA (siRNA) is a potent means of inducing gene-specific silencing. Gene silencing strategies using siRNA have demonstrated therapeutic benefits in animal models of various diseases, and are currently in clinical trials. However, the utility of gene silencing as a treatment for allergic diseases has not yet been reported. In this study, we report a novel therapy for allergy through gene silencing of CD40, a critical costimulatory molecule and a key factor in allergic immune responses. Silencing CD40 resulted in generation of immunoregulatory dendritic cells (DCs). Administration of CD40 siRNA remarkably reduced nasal allergic symptoms and local eosinophil accumulation in the OVA-induced allergic mice. The OVA-specific T cell response was inhibited after the CD40 siRNA treatment. Additionally, anti-OVA specific IgE and production of IL-4 and IL-5 of T cells stimulated by OVA were significantly decreased in CD40 siRNA-treated mice. Furthermore, we demonstrated that the therapeutic effects by CD40 siRNA were associated with impaired Ag-presenting functions of DCs and B cells, and generation of regulatory T cells. The present study highlights a therapeutic potential of siRNA-based treatment for allergic diseases.

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A Possible Role of CD4⁺CD25⁺ T Cells as Well as Transcription Factor Foxp3 in the Dysregulation of Allergic Rhinitis

Abstract: Our results indicate that CD4(+) CD25(+) regulatory T cells as well as Foxp3 may play a crucial role in immunological imbalance of AR. These findings suggest that increasing Foxp3 and CD4(+)CD25(+) T cells have the potential to be new therapeutic targets for the treatment of AR.

Cited by 52 publications

References 15 publications

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

Frequency and Activation of CD4+CD25high FoxP3+ Regulatory T Cells in Peripheral Blood from Children with Atopic Allergy

Novel Vaccination for Allergy through Gene Silencing of CD40 Using Small Interfering RNA

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A Possible Role of CD4+CD25+ T Cells as Well as Transcription Factor Foxp3 in the Dysregulation of Allergic Rhinitis

Abstract: Our results indicate that CD4(+) CD25(+) regulatory T cells as well as Foxp3 may play a crucial role in immunological imbalance of AR. These findings suggest that increasing Foxp3 and CD4(+)CD25(+) T cells have the potential to be new therapeutic targets for the treatment of AR.

Cited by 52 publications

References 15 publications

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

Analysis of regulatory T cell associated forkhead box P3 expression in the lungs of patients with sarcoidosis

Frequency and Activation of CD4+CD25high FoxP3+ Regulatory T Cells in Peripheral Blood from Children with Atopic Allergy

Novel Vaccination for Allergy through Gene Silencing of CD40 Using Small Interfering RNA

Contact Info

Product

Resources

About

A Possible Role of CD4⁺CD25⁺ T Cells as Well as Transcription Factor Foxp3 in the Dysregulation of Allergic Rhinitis