A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and NG-nitro-l-arginine hypertensive rats

Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats

“…The experiments on rats were approved by the Institutional Animal Ethical Committee (IAEC) (No. IAEC/KMC/20/2009-2010 and were conducted according to the CPCSEA guidelines.…”

Preclinical efficacy of a gastro-sparing novel thiazolidin-4-one in alleviating secondary lesions of polyarthritis: A multi-parametric approach

“…To assess the possible effect of the arthritis/treatments on blood pressure of AIA rats, a non-invasive method of blood pressure (NIBP) measurement was adopted, as reported earlier (Bankar et al, 2010;Bankar et al, 2011). Animals were first acclimatized in the rat holder for 2 h in three subsequent trials.…”

“…According to previously reported method (Bankar et al, 2010;Bankar et al, 2009), aortic rings were isolated after sacrificing the rats and the isometric contractions and relaxations were recorded using force displacement transducer (AD Instruments, Australia). Cumulative concentration -response curves (1 nM-30 μM) of phenylephrine (PE) and sodium nitroprusside (SNP) were performed in thoracic aortic rings isolated from normal control/AIA/diclofenac (10 mg/kg)/4C (100 mg/kg) grouped rats.…”

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“…1a, b The 1,3,4-oxadiazole exhibit wide range of biological activities such as antimicrobial 2 , Antibacterial 3 , anti-inflammatory 4,5 , anti tubercular 6 , anticancer 7a, b , anthelmintic 8 , antihypertensive 9 . anti HIV 10,11 and anticonvulsant 12 , etc.…”