A Possible Central Antinociceptive Effect of Dipyrone in Mice

Akman, Hasan O.; Aksu, Fazilet; Gültekin, İlhan; Özbek, Hayri; Oral, Uğur; Doran, Figen; Baysal, Firuz

doi:10.1159/000139417

Cited by 31 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anti-inflammatory agents (including 3,5-pyrazolinediones) are usually devoid of antinociceptive activity in thermal stimulation tests (22). Therefore, although it seems unlikely that a putative anti-inflammatory action underlies the presently reported antinociceptive action of Pz 2 and Pz 3, further specific studies about the anti-inflammatory potential of these compounds are necessary to clarify this point.…”

Section: Discussionmentioning

confidence: 97%

Antinociceptive effect of novel pyrazolines in mice

Tabarelli

Rubin

Berlese

et al. 2004

Braz J Med Biol Res

View full text Add to dashboard Cite

The antinociceptive effect of six novel synthetic pyrazolines (3-ethoxymethyl-5-ethoxycarbonyl-1H-pyrazole (Pz 1) and its corresponding 1-substituted methyl (Pz 2) and phenyl (Pz 3) analogues, and 3-(1-ethoxyethyl)-5-ethoxycarbonyl-1H-pyrazole (Pz 4) and its corresponding 1-substituted methyl (Pz 5) and phenyl (Pz 6) analogues) was evaluated by the tail immersion test in adult male albino mice. The animals (N = 11-12 in each group) received vehicle (5% Tween 80, 10 ml/kg, sc) or 1.5 mmol/kg of each of the pyrazolines (Pz 1-Pz 6), sc. Fifteen, thirty and sixty minutes after drug administration, the mice were subjected to the tail immersion test. Thirty minutes after drug administration Pz 2 and Pz 3 increased tail withdrawal latency (vehicle = 3.4 ± 0.2; Pz 2 = 5.2 ± 0.4; Pz 3 = 5.9 ± 0.4 s; mean ± SEM), whereas the other pyrazolines did not present antinociceptive activity. Doseeffect curves (0.15 to 1.5 mmol/kg) were constructed for the bioactive pyrazolines. Pz 2 (1.5 mmol/kg, sc) impaired motor coordination in the rotarod and increased immobility in the open-field test. Pz 3 did not alter rotarod performance and spontaneous locomotion, but increased immobility in the open field at the dose of 1.5 mmol/kg. The involvement of opioid mechanisms in the pyrazoline-induced antinociception was investigated by pretreating the animals with naloxone (2.75 µmol/kg, sc). Naloxone prevented Pz 3-but not Pz 2-induced antinociception. Moreover, naloxone pretreatment did not alter Pz 3-induced immobility. We conclude that Pz 3-induced antinociception involves opioid mechanisms but this is not the case for Pz 2.

show abstract

Section: Discussionmentioning

confidence: 97%

Antinociceptive effect of novel pyrazolines in mice

Tabarelli

Rubin

Berlese

et al. 2004

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Dipyrone was purchased from Sigma Chemical Company, dissolved in 0.9% saline and administered 100 or 200 mg/kg/per day. Drug doses and dosing times were chosen according to the previous studies [11].…”

Section: Experimental Groups and Drug Administrationmentioning

confidence: 99%

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Kıroğlu¹,

Demirkol²,

Berktaş³

et al. 2016

CIM

Self Cite

View full text Add to dashboard Cite

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences Abstract Purpose: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects.Methods: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks. Dipyrone was administered intraperitoneally beginning from the third week. Splash, rota-rod (RR) and forced swimming (FST) tests were performed at the seventh week as behavioural tests to evaluate the antidepressant-like effects of dipyrone. Coat state score (CSS) and weights of animals were recorded at seventh weeks. Results were analyzed using one or two-way ANOVA followed by the Bonferonni post hoc test.Results: Weight of UCMS-exposed mice did not change compared with controls; however, significant changes were observed in CSS in both sexes of stressed mice (p<0.05). RR latency decreased and immobility time enhanced in FST test in both sexes of stressed mice (p<0.05). Grooming behaviour was not different between the groups in female mice, but different in male mice in the splash test. Dipyrone did not produce a significant change in CSS in the UCMS-exposed group but reversed the latency time and immobility time to normal values in both sexes of mice and augmented the number of grooming behaviour only in stressed male mice. Conclusion:These results indicate that dipyrone produce antidepressant-like effects to some symptoms of UCMS according to gender.SUPPLEMENT

show abstract

“…The tail clip test to pressure, the tail flick to radiant heat and the hot plate test were used to test central antinociceptive activity. Actually, since it has been reported that aspirin-like drugs [23], especially dipyrone (Novalgine, Metamizole) [24,25], also show a central analgesic effect, we explored the central analgesic effect of our synthesized compounds. The peripheral activity was evaluated using the acetic acid-induced stretching test [26].…”

Section: Pharmacologymentioning

confidence: 99%

Synthesis and Antinociceptive Activity of (5‐Chloro‐2(3H)‐benzothiazolon‐3‐yl)propanamide Derivatives

Önkol

Yıldırım

Erol

et al. 2004

Archiv der Pharmazie

View full text Add to dashboard Cite

Ten new (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1-[3-(5-chloro-2(3H)-benzothiazolon-3-yl)-propanoyl]-4-(4-chlorophenyl)piperazine (11e) has been found to be significantly more active than the other compounds synthesized as well as the standards in all tests.

show abstract

A Possible Central Antinociceptive Effect of Dipyrone in Mice

Cited by 31 publications

References 18 publications

Antinociceptive effect of novel pyrazolines in mice

Antinociceptive effect of novel pyrazolines in mice

Dipyrone ameliorates behavioural changes induced by unpredictable chronic mild stress: gender differences

Synthesis and Antinociceptive Activity of (5‐Chloro‐2(3H)‐benzothiazolon‐3‐yl)propanamide Derivatives

Contact Info

Product

Resources

About