A Possible Case of COVID-19 Booster Vaccine–Associated Rhabdomyolysis and Acute Kidney Injury

Unger, Kendra; Ponte, Charles D.; Anderson, Dylan

doi:10.1177/87551225221093944

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…Data regarding vaccine-induced rhabdomyolysis is limited however some studies have described cases of rhabdomyolysis related to mRNA COVID-19 vaccination including Pfizer-BioNTech and Moderna vaccines [ 27 , 28 , 29 , 30 , 31 ]. These patients presented with muscle pain and fatigue up to two weeks after vaccination.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis after COVID-19 Infection: A Case Report and Review of the Literature

Bawor

Sairam

Rozewicz

et al. 2022

Viruses

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Rhabdomyolysis is a condition in which muscle breaks down potentially leading to renal dysfunction, and often occurs secondary to a precipitating factor. Viral or bacterial infections are common precipitants for initiating rhabdomyolysis. Recently, healthcare systems across the world have been challenged by a pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing ‘coronavirus disease 2019’ (COVID-19) disease. SARS-CoV-2 infection is recognized to cause respiratory and cardiovascular compromise, thromboembolic events, and acute kidney injury (AKI); however, it is not known whether it can precipitate rhabdomyolysis, with only a limited number of cases of SARS-CoV-2 infection preceding rhabdomyolysis reported to date. Here, we report the case of a 64-year-old woman who developed rhabdomyolysis shortly after SARS-CoV-2 infection and COVID-19. She initially presented with muscular pain, a creatine kinase level of 119,301 IU/L, and a mild rise in her creatinine level to 92 µmol/L, but successfully recovered with intravenous fluid support. We also review the literature to summarise previously reported cases of rhabdomyolysis precipitated by SARS-CoV-2, highlighting the need to consider this diagnosis in patients presenting with SARS-CoV-2 and myalgia.

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Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis after COVID-19 Infection: A Case Report and Review of the Literature

Bawor

Sairam

Rozewicz

et al. 2022

Viruses

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“…In the literature, 10 cases of rhabdomyolysis after COVID-19 vaccination have been reported. In these cases, the patients were vaccinated with Moderna, Comirnaty, AstraZeneca, Johnson & Johnson, and a non-specified COVID-19 vaccine [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…All patients were treated with IV fluids. In 4/10 cases, complaints and CK levels resolved partly after discharge but with limited follow-up [ 4 , 5 , 6 , 11 ]. In 4/10 cases, complaints and CK levels resolved completely [ 7 , 8 , 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report

Ruijters¹,

Meulen²,

Es³

et al. 2022

Case Rep Neurol

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Rhabdomyolysis is an acute disruption in skeletal muscle integrity, leading to the rapid release of 4 muscle contents into the bloodstream, such as creatine kinase (CK). It can have various causes, including infections. Throughout the pandemic, multiple cases of rhabdomyolysis following COVID-19 infections have been reported. However, rhabdomyolysis subsequent to COVID-19 vaccinations appears to be relatively rare. Here, we report such a case after a second COVID-19 Comirnaty (BioNTech/Pfizer) vaccination. Our patient developed rhabdomyolysis 1 day after the second Comirnaty vaccination with high creatine kinase (CK) levels, generalized weakness, and kidney failure. CK levels and muscle weakness resolved after treatment with intravenous fluids, but unfortunately, he remained hemodialysis dependent after discharge. To our knowledge, this is one of the first case reports describing a patient with rhabdomyolysis after a Comirnaty vaccination. However, as millions of people have received the Comirnaty vaccine, it is unclear whether the rhabdomyolysis in our patient is a rare side effect or an unrelated, coincidental event. Large observational studies are needed to elucidate the causality between the Comirnaty vaccination and rhabdomyolysis. Awareness is warranted in patients with myalgia and muscle weakness shortly after COVID-19 vaccination, in order to initiate treatment early and prevent life-threatening complications.

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“…However, this may arise from an exaggerated immune response to adjuvants, possibly potentiated by prior exposure to the COVID-19 virus ( 46 , 54 ). Clinicians should be aware of the possibility of rhabdomyolysis as a complication of COVID-19 vaccination because, in such cases, early diagnosis and intervention, including vigorous hydration and elimination of factors that potentiate AKI, may be crucial for a better prognosis ( 56 ).…”

Section: Morphological Findings In Renal Involvement Post Covid-19 Va...mentioning

confidence: 99%

Kidney injury associated with COVID-19 infection and vaccine: A narrative review

et al. 2022

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The respiratory tract is the main infection site for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in many admissions to intensive care centers in several countries. However, in addition to lung involvement, kidney injury caused by the novel coronavirus has proven to be a significant factor related to high morbidity and mortality, alarming experts worldwide. The number of deaths has drastically reduced with the advent of large-scale immunization, highlighting the importance of vaccination as the best way to combat the pandemic. Despite the undeniable efficacy of the vaccine, the renal side effects associated with its use deserve to be highlighted, especially the emergence or reactivation of glomerulopathies mentioned in some case reports. This study aimed to identify the main renal morphological findings correlated with COVID-19 infection and its vaccination, seeking to understand the pathophysiological mechanisms, main clinical features, and outcomes.

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A Possible Case of COVID-19 Booster Vaccine–Associated Rhabdomyolysis and Acute Kidney Injury

Cited by 11 publications

References 10 publications

Rhabdomyolysis after COVID-19 Infection: A Case Report and Review of the Literature

Rhabdomyolysis after COVID-19 Infection: A Case Report and Review of the Literature

Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report

Kidney injury associated with COVID-19 infection and vaccine: A narrative review

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