Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report

Ruijters, V J; Meulen, M. F. G. van der; Es, Michael A. van; Smit, Tessa; Hoogendijk, Jessica E.

doi:10.1159/000527599

Cited by 4 publications

(2 citation statements)

References 13 publications

(22 reference statements)

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“…The diffuse myositis observed with SARS-CoV-2 infection and the failure to consistently identify viral particles in myocytes suggests that the myositis is a result of the "cytokine storm" brought on by the infection. When the myositis is severe, the myoglobin released from muscle breakdown can cause a form of kidney failure referred to as rhabdomyolysis [95][96][97][98]. The effects of acute kidney failure with SARS-CoV-2 infection will be discussed in a later section.…”

Section: Muscle Weakness and Mechanical Unloadingmentioning

confidence: 99%

COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions

Creecy,

Awosanya,

Harris

et al. 2024

Curr Osteoporos Rep

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Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss. The purpose of this review is to summarize recent findings related to bone loss and potential mechanisms. Recent Findings The early clinical evidence indicates an increase in vertebral fractures, hypocalcemia, vitamin D deficiencies, and a loss in BMD among COVID-19 patients. Additionally, lower BMD is associated with more severe SARS-CoV-2 infection. Preclinical models have shown bone loss and increased osteoclastogenesis. The bone loss associated with SARS-CoV-2 infection could be the result of many factors that directly affect the bone such as higher inflammation, activation of the NLRP3 inflammasome, recruitment of Th17 cells, the hypoxic environment, and changes in RANKL/OPG signaling. Additionally, SARS-CoV-2 infection can exert indirect effects on the skeleton, as mechanical unloading may occur with severe disease (e.g., bed rest) or with BMI loss and muscle wasting that has also been shown to occur with SARS-CoV-2 infection. Muscle wasting can also cause systemic issues that may influence the bone. Medications used to treat SARS-CoV-2 infection also have a negative effect on the bone. Lastly, SARS-CoV-2 infection may also worsen conditions such as diabetes and negatively affect kidney function, all of which could contribute to bone loss and increased fracture risk. Summary SARS-CoV-2 can negatively affect the bone through multiple direct and indirect mechanisms. Future work will be needed to determine what patient populations are at risk of COVID-19-related increases in fracture risk, the mechanisms behind bone loss, and therapeutic options. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.

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Section: Muscle Weakness and Mechanical Unloadingmentioning

confidence: 99%

COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions

Creecy,

Awosanya,

Harris

et al. 2024

Curr Osteoporos Rep

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“…Additionally, SARS-CoV-2-associated rhabdomyolysis has been reported to the vaccine adverse event reporting system (VAERS) in 20 cases through July 2021 [4]. Ten more cases have been reported to the Netherlands Pharmacovigilance Centre Lareb and 536 cases to VigiBase, the World Health Organization's (WHO) global individual case safety report (ICSR) database [4]. A search of VAERS in November 2021 revealed 386 reported cases of COVID-19 vaccine-related rhabdomyolysis [7].…”

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confidence: 99%

Diagnosing SARS-CoV-2 vaccination-related rhabdomyolysis requires the exclusion of all differential causes

Finsterer¹

2023

Pediatr Nephrol

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Letter to the Editor,We read with interest the article by Pucchio et al. about a 16-year-old male with rhabdomyolysis that appeared a few hours after the first dose of the BNT162b2 vaccine [1]. The patient manifested clinically with severe, progressive myalgia and cola-like urine with a maximum creatine-kinase (CK) value of 147,600 U/l on hospital day 2 [1]. The patient benefited from intravenous fluids and sodium bicarbonate and made a full recovery [1]. The study is appealing but raises concerns that warrant further discussion.According to a literature review, more than the two pediatric patients with SARS-CoV-2 vaccination-associated rhabdomyolysis as described by Pucchio et al. [1] have been documented. In addition to the index patient and the 16-year-old female with rhabdomyolysis after the second BNT162b2 dose [1], several other pediatric and adult patients with SARS-CoV-2 vaccination-associated rhabdomyolysis have been noted in publications (Table 1). SARS-CoV-2 vaccination-related rhabdomyolysis was also reported in a 16-year-old female after the second BNT162b2 dose [2], in a 19-year-old male after receiving the Johnson and Johnson vaccine [3], and in a 16-yearold male after receiving the second dose of BNT162b2 (Table 1).The number of adult patients with SARS-CoV-2 vaccination-associated rhabdomyolysis is higher than presented in Table 1 of Pucchio's article [1]. More than eight adult patients have been reported. When searching Pub-Med through the end of December 2022, five pediatric and at least 13 adult cases with SARS-CoV-2-associated * Josef Finsterer

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A severe case of rhabdomyolysis after Moderna mRNA anti‐COVID‐19 vaccine with a literature review

Sheka

Coattrenec

Lorenzini

et al. 2023

Clinical Case Reports

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Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report

Cited by 4 publications

References 13 publications

COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions

COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions

Diagnosing SARS-CoV-2 vaccination-related rhabdomyolysis requires the exclusion of all differential causes

A severe case of rhabdomyolysis after Moderna mRNA anti‐COVID‐19 vaccine with a literature review

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