A possible antiviral effect of amantadine in an AH1N1 influenza-infected patient – a case report

Repurposing of Adamantanes for the Treatment of COVID-19: Rationale and Perspectives

“…events in Herpes Simplex virus type 1 replication [7]. More recently, in a case of severe AH1N1 viral pneumonia causing CNS disorder and multi-organ failure, amantadine was found to be neuroprotective while also appearing to result in cessation of viral shedding that contributed to positive outcome and discharge from the ICU [8]. Importantly, a series of novel 2-aminoadamantanes have been synthesized and shown to manifest persistent in vitro efficacy against H1N1 [2009] Influenza A where addition of as little as one CH2 group to the methyl adduct of the amantadine/rimantadine analogue 2-methyl-2-aminoadamantane resulted in activity of a range of H1N1 viral strains [9].…”