A positive family history of hypertension might be associated with an accelerated onset of type 2 diabetes: Results from the National Center Diabetes Database (NCDD-02)

Yamamoto‐Honda, Ritsuko; Mori, Yusaku; Yamashita, Satoshi; Yoshida, Yoko; Kawazu, Shoji; Iwamoto, Yasuhiko; Kajio, Hiroshi; Yanai, Hidekatsu; Mishima, Saori; Handa, Nobuhiro; Shimokawa, Kuniyasu; Yoshida, Akihiro; Watanabe, Hiroki; Shimbo, Takuro; Noda, Mitsuhiko

doi:10.1507/endocrj.ej16-0521

Cited by 8 publications

(7 citation statements)

References 30 publications

(30 reference statements)

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“…The present study identified twelve national clinical diabetes registries spread over four different continents, mostly concentrated in the Northern part of Europe [13,14,57,[65][66][67][68][69][70][71][72]. Altogether, these databases comprised a total of 7,181,356 diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

National diabetes registries: do they make a difference?

et al. 2020

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Aims The global epidemic of diabetes mellitus continues to expand, including its large impact on national health care. Measuring diabetes outcomes and their causes of variation highlights areas for improvement in care and efficiency gains; large registries carry this potential. By means of a systematic review, we aimed to give an overview of national registries worldwide by quantifying their data and assessing their influence on diabetes care. Methods The literature on MEDLINE up to March 31, 2020, was searched, using keywords diabetes mellitus, national, registry, registration, and/or database. National disease-specific registries from corresponding articles were included. Database characteristics and clinical variables were obtained. All registries were compared to the ICHOM standard set of outcomes. Results We identified 12 national clinical diabetes registries, comprising a total of 7,181,356 diabetic patients worldwide. Nearly all registries recorded weight, HbA1c, lipid profile, and insulin treatment; the recording of other variables varied to a great extent. Overall, registries corresponded fairly well with the ICHOM set. Most registries proved to monitor and improve the quality of diabetes care using guidelines as a benchmark. The effects on national healthcare policy were more variable and often less clear. Conclusions National diabetes registries confer clear insights into diagnostics, complications, and treatment. The extent to which registries influenced national healthcare policy was less clear. A globally implemented standard outcome set has the potential to improve concordance between national registries, enhance the comparison and exchange of diabetes outcomes, and allocate resources and interventions where most needed.

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Section: Discussionmentioning

confidence: 99%

National diabetes registries: do they make a difference?

et al. 2020

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“…Due to the high costs and low cooperation rate among patients, family history was regarded as a direct or indirect interpretation of inheritable risk factor which helps clinicians to evaluate the risk for DR. It is reported that presence of family history, diabetes, and hypertension, always indicated lower age of the patients which is associated to rather longer duration of diabetes for these patients [6,7]. In addition, researches revealed a family history of diabetes and hypertension also contributed to a higher frequency of DR [8,9].…”

Section: Introductionmentioning

confidence: 95%

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

Wang

Chen

Yang

et al. 2020

Diabetol Metab Syndr

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Background: Diabetic retinopathy (DR) is a specific neurovascular complication of diabetes mellitus (DM). Clinically, family history is a widely recognized risk factor for DR, assisting diagnosis and risk strata. However, among a great amount of DR patients without hereditary history like hypertension and diabetes, direct and simple risk factors to assist clinical decisions are still required. Herein, we intend to investigate the associated risk factors for these DR patients based on systemic inflammatory response indexes, neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR). Methods: We consecutively enrolled 1030 patients with a definite diagnosis of type 2 diabetes mellitus (T2DM) from the endocrinology department of the Second hospital of People in Yun Nan. Based on funduscopy and family history checking, we excluded patients with a family history of hypertension and diabetes and finally enrolled 264 patients with DR and 206 patients with non-diabetic retinopathy (NDR). Through correlation analysis, univariate and multivariate regression, we further explore the association between NLR, PLR, and DR. On top of that, we investigate the effect of NLR and PLR on risk reclassification of DR. Results: Compared with NDR patients, NLR and PLR levels are significantly higher among DR patients (NLR: 2.36 ± 1.16 in DR group versus 1.97 ± 1.06 in NDR group, p < 0.001; PLR: 11.62 ± 4.55 in DR group versus10.56 ± 4.45 in NDR group, p = 0.012). According to univariate analysis, NLR and PLR add risks to DR. After fully adjusting co-founders, NLR, as both continuous and categorical variate, remains an independent risk factor for DR (OR (95%CI): 1.37 (1.06, 1.78) P = 0.018). And though PLR was not independently associated with DR as a continuous variable (OR (95%CI) 1.05 (0.99, 1.11) p = 0.135), the highest quantile of PLR add twofold increased risk (OR (95%CI) 2.20 (1.05, 4.59) p = 0.037) in the fully adjusted model for DR. In addition, addition of PLR and NLR to the established factor hemoglobin (Hb) improved the discriminability of the model and assisted the reclassification of DR. After combining PLR and NLR the

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“…Journal of Diabetes Research risk of diabetes and speeds up diabetes occurrence. A retrospective study conducted on 1299 patients revealed that patients with a family history of hypertension develop diabetes mellitus two years earlier than those without a family history [32]. Obesity was the other factor that had a statistically significant connection.…”

Section: Discussionmentioning

confidence: 99%

New Onset of Diabetes Mellitus and Associated Factors among COVID-19 Patients in COVID-19 Care Centers, Addis Ababa, Ethiopia 2022

Habtamu

Sibhat

Tsegaw

et al. 2022

Journal of Diabetes Research

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Introduction. New onset of diabetes mellitus was noted as the commonest comorbidity in the COVID-19 pandemic, which contributed to a worse prognosis. Existing evidence showed that new-onset diabetes is associated with increased mortality compared to nondiabetic and known diabetic patients in the COVID-19 era. SARS-CoV-2 virus can worsen existing diabetes; at the same time, it can trigger new-onset diabetes that eventually worsens patient outcomes. Thus, this study is aimed at determining the prevalence and factors associated with new onset of diabetes mellitus among COVID-19 patients. Methods. Institution-based retrospective cross-sectional study design was conducted by reviewing 244 patient’s records in the Addis Ababa COVID-19 care center. Descriptive statistics and binary logistic regression were used. During bivariate analysis, variables with p ≤ 0.25 were transferred into multivariate analysis. Adjusted odds ratios to determine the strength and presence of the association with a 95% confidence interval and p value ≤ 0.05 were considered, respectively. Results. The mean age of the study participants was 53.2 years with ( SD = 13.35 ). The study findings showed that 31.1% (CI: 25.4-37.4) of COVID-19 patients had new onset of diabetes mellitus; of those, 11.8% had type 1 and 88.2% had type 2 diabetes. Being male ( aOR = 2.9 ; 95% CI: 1.2, 7.1), family history of hypertension ( aOR = 3.7 ; 95% CI: 1.3, 10.5), obesity ( aOR = 3.1 ; 95% CI: 1.01, 8.9), having pulmonary embolism ( aOR = 0.2 ; 95% CI: 0.06, 0.04), and hyperkalemia ( aOR = 9.3 ; 95% CI: 1.8, 47.3) showed statistically significant association with new onset of diabetes mellitus. Conclusion. A significant proportion of COVID-19 patients had been diagnosed with new onset of diabetes mellitus, and new-onset type 2 diabetes mellitus is the most common diabetes mellitus type. Being male, obesity, having a pulmonary embolism, family history of hypertension, and hyperkalemia were independently associated with new onset of diabetes mellitus among COVID-19 patients. Therefore, focused interventions need to be strengthened towards the identified factors.

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A positive family history of hypertension might be associated with an accelerated onset of type 2 diabetes: Results from the National Center Diabetes Database (NCDD-02)

Cited by 8 publications

References 30 publications

National diabetes registries: do they make a difference?

National diabetes registries: do they make a difference?

Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history

New Onset of Diabetes Mellitus and Associated Factors among COVID-19 Patients in COVID-19 Care Centers, Addis Ababa, Ethiopia 2022

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