A portrait of Staphylococcus aureus from the other side of the Mediterranean Sea: molecular characteristics of isolates from Western Algeria

Abstract

Algerian hospitals have experienced a dramatic increase in methicillin-resistant Staphylococcus aureus (MRSA) prevalence in recent years. To investigate this phenomenon, we have determined molecular characteristics of 61 methicillin-resistant or -susceptible strains isolated between 2003 and 2007 in Oran Hospital. Susceptible isolates were related to diverse genetic backgrounds, of which clone with sequence type (ST) 8 accounted for most of the samples. Resistance to methicillin was almost limited to two international spreading clones; the most frequent, ST80, contained isolates producing Panton-Valentine leukocidine, with SCCmec type IV. The increase of MRSA prevalence observed in Western Algeria, in outpatients as well as in hospitalized patients, is linked to dissemination of ST80 strains usually considered as community-acquired MRSA.

Distribution of the Most Prevalent Spa Types among Clinical Isolates of Methicillin-Resistant and -Susceptible Staphylococcus aureus around the World: A Review

“…Out of the remaining articles, 253 fulfilled our inclusion criteria (Shopsin et al, 1999; Graille et al, 2000; Fey et al, 2003; Arakere et al, 2005; Denis et al, 2005; Ko et al, 2005; Aires-de-Sousa et al, 2006, 2008; Deplano et al, 2006; Durand et al, 2006; Ferry et al, 2006, 2010; Fossum and Bukholm, 2006; Jury et al, 2006; Kuhn et al, 2006; Mellmann et al, 2006, 2008; Montesinos et al, 2006; Ruppitsch et al, 2006, 2007; Sabat et al, 2006; Cai et al, 2007, 2009; Conceicao et al, 2007; Cookson et al, 2007; Ellington et al, 2007a,b; Ghebremedhin et al, 2007; Hallin et al, 2007, 2008; Krasuski et al, 2007; Matussek et al, 2007; Otter et al, 2007; Tristan et al, 2007; Van Loo et al, 2007; Vourli et al, 2007; Werbick et al, 2007; Witte et al, 2007; von Eiff et al, 2007; Bartels et al, 2008, 2013, 2014; Chaberny et al, 2008; Chmelnitsky et al, 2008; Gardella et al, 2008; Fenner et al, 2008a,b; Golding et al, 2008, 2011; Ho et al, 2008a,b, 2012, 2016, 2017; Jappe et al, 2008; Karynski et al, 2008; Larsen et al, 2008, 2009; Nulens et al, 2008; Pérez-Vázquez et al, 2008; Strommenger et al, 2008; Vainio et al, 2008, 2011; Zhang et al, 2008, 2009; Alp et al, 2009; Argudín et al, 2009, 2011; Atkinson et al, 2009; Bekkhoucha et al, 2009; Chen et al, 2009; Chen H.-J. et al, 2010; Chen L. et al, 2010; Chen et al, 20...…”

Virulence properties of methicillin-susceptible Staphylococcus aureus food isolates encoding Panton–Valentine Leukocidin gene

“…Interestingly, not only PVL-positive MRSA isolates, but also PVL-positive MSSA isolates from different countries have been reported having ST152 clonal type. More recently, PierreYves Donnio has reported in MLST.net two PVL-positive MSSA strains having ST152 and t355 clonal types which were isolated from France (unpublished data) and Algeria (Bekkhoucha et al, 2009) in clinical specimens. Moreover, Ruimy et al (2008) reported 7 MSSA strains, which were nasal carriage isolates in Mali, showed ST152 and t355 clonal types.…”

Atypical Pneumonia Linked to Community-Acquired <b><i>Staphylococcus aureus</i></b> Cross-Transmission in the Nursery

“…When PVL is associated with MRSA, bactericidal antibiotics such as vancomycin or linezolid are also required [7]. The strains involved in this report all belonged to the European CA-MRSA clone, a minor clone described in invasive CA-MRSA infections in France [8], which is endemic in Algeria where the index mother lived [9]. …”