A porous material excited by near-infrared light for photo/chemodynamic and photothermal dual-mode combination therapy

Sun, Mingdi; Yang, Dan; Sun, Qianqian; Jia, Tao; Kuang, Ye; Gai, Shili; He, Fei; Zhang, Fangmei; Yang, Piaoping

doi:10.1039/d0tb01794a

Cited by 16 publications

(12 citation statements)

References 70 publications

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“…There are some examples of using Cu‐containing nanomaterials for CDT‐involved multimodal therapy, [ 253–270 ] some of which are listed in Table 2. For example, Cu‐based CDT together with other therapies can enhance cancer immunotherapy.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

“…constructed a SiO 2 @CuO nanotube (NT) through a hydrothermal co‐precipitation template approach for PDT/PTT/CDT. [ 255 ] In this nanosystem, CuO, as a p‐type semiconductor, could liberate electrons and form holes under the NIR laser irradiation. The electrons and holes then reacted with O 2 ‐containing substances to generate O 2 •− for PDT.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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341

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

Small

341

212

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“…In comparison, aqueous dispersed CuO NPs (AquÀ CuO NPs) were also synthesized via hydrothermal method. [15] 0.8 mmol cupric acetate monohydrate was dispersed in 35 mL H 2 O to form a transparent blue solution. 0.5 M NaOH solution was then added in until the solution turned dark blue.…”

Section: Synthesis Of Oleylamine Stabilized Cuo Nanoparticles (Oamà C...mentioning

confidence: 99%

“…However, it's difficult to control particle size, morphology, or obtain porous structure for currently reported CuO nanoparticles synthesized through hydrothermal method. [15] Therefore, Fenton-like reaction only proceeded at the surface of nanomaterial while inner part remained unreacted, which greatly limited * OH production efficiency. [16] CuS [17] and Coppercysteamine [18] that directly synthesized in aqueous phase require external energy input, such as NIR light, UV irradiation, and low-dose MW excitation, to stimulate ROS generation for satisfactory therapeutic result.…”

Section: Introductionmentioning

confidence: 99%

“…[16] CuS [17] and Coppercysteamine [18] that directly synthesized in aqueous phase require external energy input, such as NIR light, UV irradiation, and low-dose MW excitation, to stimulate ROS generation for satisfactory therapeutic result. Precipitation on nanotemplate like SiO 2 [15] or developing copper based MOF [19] could stabilize nanoparticle structure and increase Fenton-like reaction efficiency. However, the content of Cu(II), as the reactant for Fenton-like reaction, is low due to the existence of template or ligand molecule.…”

Section: Introductionmentioning

confidence: 99%

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Self‐assembled Cupric Oxide Nanoclusters for Highly efficient chemodynamic therapy

Jin

Zhao

Zhang

et al. 2022

Chemistry An Asian Journal

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Chemodynamic therapy (CDT) based on Fenton and Fenton-like reactions induces cancer cell killing via in situ catalyzing H 2 O 2 and generating highly oxidative hydroxyl radicals ( * OH) in tumor sites. Their application is not limited by tumor grown depth or hypoxic microenvironment. However, the reaction efficiency is still hampered due to the structure of catalytic agents and the requirement for low pH environment. Here, we design a porous CuO nanocluster (CuO NC) through self-assembly of oleylamine stabilized CuO NPs (OAmÀ CuO NPs), and functionalize it with folic acid (CuO NC-FA) for specific tumor cell targeting. It can catalyze H 2 O 2 with high efficiency in nearly neutral environment. Besides, the porous structure of CuO NC also helps the diffusion of H 2 O 2 to the interior of nanocluster to further improve Fentonlike reaction efficiency. The convenient synthesis of CuO NC-FA with good Fenton-like reaction efficiency at neutral environment demonstrates good chemodynamic therapy effect.

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Temperature‐Dependent CAT‐Like RGD‐BPNS@SMFN Nanoplatform for PTT‐PDT Self‐Synergetic Tumor Phototherapy

Song

Chen

Qin

et al. 2021

Adv Healthcare Materials

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Phototherapies such as photothermal therapy (PTT) and photodynamic therapy (PDT) are considered as alternatives for tumor remedies, because of their advantages of precise spatial orientation, minimally invasive, and nonradiative operation. However, most of phototherapeutic agents still suffer from low photothermal conversion efficacy and photodynamic performance, poor biocompatibility, and intratumor accumulation. Herein a biocompatible and target-deliverable PTT-PDT self-synergetic nanoplatform of RGD-BPNS@SMFN based on temperature-dependent catalase (CAT)-like behavior for tumor elimination is presented. The homogeneously dispersible nanoplatform is designed and fabricated through anchoring spherical manganese ferrite nanoparticles (SMFN) to black phosphorus nanosheets (BPNS), followed by arginine-glycine-aspartic acid (RGD) peptide modification. The nanoplatform exhibits excellent targeting ability and enhanced photonic response in comparison to plain BPNS and SMFN in vitro and in vivo. It is found that PTT and PDT have a self-synergetic behavior by means of the dual phototherapy mode interaction. The self-synergetic mechanism is mainly ascribed to PTT-promoted inherent CAT-like activity in the nanoplatform, which remodels the tumor hypoxia microenvironment and further ameliorates the PDT efficiency, providing promising high performance nanoplatform for synergetic dual mode phototherapy, enriching the design for the antitumor nanozyme.

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A porous material excited by near-infrared light for photo/chemodynamic and photothermal dual-mode combination therapy

Abstract: Photodynamic therapy (PDT) and photothermal therapy (PTT) are well-developing light therapy methods for cancer at present. Nevertheless, both of them have a few parts for improvement. Firstly, sustained PDT effect...

Cited by 16 publications

References 70 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Self‐assembled Cupric Oxide Nanoclusters for Highly efficient chemodynamic therapy

Temperature‐Dependent CAT‐Like RGD‐BPNS@SMFN Nanoplatform for PTT‐PDT Self‐Synergetic Tumor Phototherapy

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